Reactivation of Multidrug-Resistant HSV-1 in a Post-Allogenic Hematopoietic Stem Cell Transplant Patient: Dynamic Detection of the Rare A605V Mutation by Next-Generation Sequencing

Shuxuan Zheng; Lidewij L.W. Rümke; Bruno Tello Rubio; Malbert R.C. Rogers; Geerte L. Van Sluis; Jürgen H.E. Kuball; Annelies Riezebos-Brilman; Robert Jan Lebbink; Frans M. Verduyn Lunel

doi:10.1093/ofid/ofae250

Reactivation of Multidrug-Resistant HSV-1 in a Post-Allogenic Hematopoietic Stem Cell Transplant Patient: Dynamic Detection of the Rare A605V Mutation by Next-Generation Sequencing

Shuxuan Zheng, Lidewij L.W. Rümke, Bruno Tello Rubio, Malbert R.C. Rogers, Geerte L. Van Sluis, Jürgen H.E. Kuball, Annelies Riezebos-Brilman, Robert Jan Lebbink, Frans M. Verduyn Lunel^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

We present an immunocompromised patient with a multiresistant herpes simplex virus-1 reactivation with a rare mutation (A605V) in the viral DNA polymerase gene. Next-generation sequencing suggests the presence of multiple drug-resistant strains before treatment and altered ratios during treatment, affecting the clinical response to aciclovir and foscarnet.

Original language	English
Article number	ofae250
Journal	Open Forum Infectious Diseases
Volume	11
Issue number	5
DOIs	https://doi.org/10.1093/ofid/ofae250
Publication status	Published - 1 May 2024

Keywords

aciclovir
foscarnet
HSV-1
multidrug resistance
stem cell transplantation

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10.1093/ofid/ofae250Licence: CC BY

ofae250Final published version, 558 KBLicence: CC BY

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Zheng, S., Rümke, L. L. W., Tello Rubio, B., Rogers, M. R. C., Van Sluis, G. L., Kuball, J. H. E., Riezebos-Brilman, A., Lebbink, R. J., & Verduyn Lunel, F. M. (2024). Reactivation of Multidrug-Resistant HSV-1 in a Post-Allogenic Hematopoietic Stem Cell Transplant Patient: Dynamic Detection of the Rare A605V Mutation by Next-Generation Sequencing. Open Forum Infectious Diseases, 11(5), Article ofae250. https://doi.org/10.1093/ofid/ofae250

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title = "Reactivation of Multidrug-Resistant HSV-1 in a Post-Allogenic Hematopoietic Stem Cell Transplant Patient: Dynamic Detection of the Rare A605V Mutation by Next-Generation Sequencing",

abstract = "We present an immunocompromised patient with a multiresistant herpes simplex virus-1 reactivation with a rare mutation (A605V) in the viral DNA polymerase gene. Next-generation sequencing suggests the presence of multiple drug-resistant strains before treatment and altered ratios during treatment, affecting the clinical response to aciclovir and foscarnet.",

keywords = "aciclovir, foscarnet, HSV-1, multidrug resistance, stem cell transplantation",

author = "Shuxuan Zheng and R{\"u}mke, {Lidewij L.W.} and {Tello Rubio}, Bruno and Rogers, {Malbert R.C.} and {Van Sluis}, {Geerte L.} and Kuball, {J{\"u}rgen H.E.} and Annelies Riezebos-Brilman and Lebbink, {Robert Jan} and {Verduyn Lunel}, {Frans M.}",

note = "Publisher Copyright: {\textcopyright} 2024 The Author(s). Published by Oxford University Press on behalf of Infectious Diseases Society of America.",

year = "2024",

month = may,

day = "1",

doi = "10.1093/ofid/ofae250",

language = "English",

volume = "11",

number = "5",

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Zheng, S, Rümke, LLW, Tello Rubio, B, Rogers, MRC, Van Sluis, GL, Kuball, JHE, Riezebos-Brilman, A, Lebbink, RJ & Verduyn Lunel, FM 2024, 'Reactivation of Multidrug-Resistant HSV-1 in a Post-Allogenic Hematopoietic Stem Cell Transplant Patient: Dynamic Detection of the Rare A605V Mutation by Next-Generation Sequencing', Open Forum Infectious Diseases, vol. 11, no. 5, ofae250. https://doi.org/10.1093/ofid/ofae250

Reactivation of Multidrug-Resistant HSV-1 in a Post-Allogenic Hematopoietic Stem Cell Transplant Patient: Dynamic Detection of the Rare A605V Mutation by Next-Generation Sequencing. / Zheng, Shuxuan; Rümke, Lidewij L.W.; Tello Rubio, Bruno et al.
In: Open Forum Infectious Diseases, Vol. 11, No. 5, ofae250, 01.05.2024.

Research output: Contribution to journal › Article › Academic › peer-review

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T1 - Reactivation of Multidrug-Resistant HSV-1 in a Post-Allogenic Hematopoietic Stem Cell Transplant Patient

T2 - Dynamic Detection of the Rare A605V Mutation by Next-Generation Sequencing

AU - Zheng, Shuxuan

AU - Rümke, Lidewij L.W.

AU - Tello Rubio, Bruno

AU - Rogers, Malbert R.C.

AU - Van Sluis, Geerte L.

AU - Kuball, Jürgen H.E.

AU - Riezebos-Brilman, Annelies

AU - Lebbink, Robert Jan

AU - Verduyn Lunel, Frans M.

PY - 2024/5/1

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N2 - We present an immunocompromised patient with a multiresistant herpes simplex virus-1 reactivation with a rare mutation (A605V) in the viral DNA polymerase gene. Next-generation sequencing suggests the presence of multiple drug-resistant strains before treatment and altered ratios during treatment, affecting the clinical response to aciclovir and foscarnet.

AB - We present an immunocompromised patient with a multiresistant herpes simplex virus-1 reactivation with a rare mutation (A605V) in the viral DNA polymerase gene. Next-generation sequencing suggests the presence of multiple drug-resistant strains before treatment and altered ratios during treatment, affecting the clinical response to aciclovir and foscarnet.

KW - aciclovir

KW - foscarnet

KW - HSV-1

KW - multidrug resistance

KW - stem cell transplantation

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U2 - 10.1093/ofid/ofae250

DO - 10.1093/ofid/ofae250

M3 - Article

AN - SCOPUS:85194947717

SN - 2328-8957

VL - 11

JO - Open Forum Infectious Diseases

JF - Open Forum Infectious Diseases

IS - 5

M1 - ofae250

ER -

Reactivation of Multidrug-Resistant HSV-1 in a Post-Allogenic Hematopoietic Stem Cell Transplant Patient: Dynamic Detection of the Rare A605V Mutation by Next-Generation Sequencing

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