Re-salvage MRI-guided Focal High-dose-rate Brachytherapy for Locally Recurrent Prostate Cancer

Marieke J Van Son; Max Peters; Marinus A Moerland; Juus L Noteboom; Wietse S Eppinga; Raquel Davila Fajardo; Jan Lagendijk; Jochem R Van der Voort van Zyp

doi:10.7759/cureus.2429

Re-salvage MRI-guided Focal High-dose-rate Brachytherapy for Locally Recurrent Prostate Cancer

Marieke J Van Son, Max Peters, Marinus A Moerland, Juus L Noteboom, Wietse S Eppinga, Raquel Davila Fajardo, Jan Lagendijk, Jochem R Van der Voort van Zyp

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Prostate cancer recurrences are common, even with twenty-first-century primary prostate cancer treatment modalities. The most common salvage treatment is (delayed) hormonal therapy, which is often associated with serious side-effects. Due to the risk of significant toxicity, whole-gland targeted salvage treatments remain unpopular. Consequently, developments in focal therapies have arisen. Magnetic resonance imaging (MRI)-guided focal salvage high-dose-rate brachytherapy (HDR-BT) is a novel treatment aiming for minimal toxicity in recurrent prostate cancer patients. Repeating focal treatment could, therefore, be possible in case of post-salvage recurrence. We report the case of a 77-year-old man who underwent repeat focal HDR-BT.

Original language	English
Article number	e2429
Journal	Cureus
Volume	10
Issue number	4
DOIs	https://doi.org/10.7759/cureus.2429
Publication status	Published - 5 Apr 2018

Keywords

prostate cancer
recurrence
brachytherapy
salvage therapy
interventional magnetic resonance imaging

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title = "Re-salvage MRI-guided Focal High-dose-rate Brachytherapy for Locally Recurrent Prostate Cancer",

abstract = "Prostate cancer recurrences are common, even with twenty-first-century primary prostate cancer treatment modalities. The most common salvage treatment is (delayed) hormonal therapy, which is often associated with serious side-effects. Due to the risk of significant toxicity, whole-gland targeted salvage treatments remain unpopular. Consequently, developments in focal therapies have arisen. Magnetic resonance imaging (MRI)-guided focal salvage high-dose-rate brachytherapy (HDR-BT) is a novel treatment aiming for minimal toxicity in recurrent prostate cancer patients. Repeating focal treatment could, therefore, be possible in case of post-salvage recurrence. We report the case of a 77-year-old man who underwent repeat focal HDR-BT.",

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author = "{Van Son}, {Marieke J} and Max Peters and Moerland, {Marinus A} and Noteboom, {Juus L} and Eppinga, {Wietse S} and {Davila Fajardo}, Raquel and Jan Lagendijk and {Van der Voort van Zyp}, {Jochem R}",

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TY - JOUR

T1 - Re-salvage MRI-guided Focal High-dose-rate Brachytherapy for Locally Recurrent Prostate Cancer

AU - Van Son, Marieke J

AU - Peters, Max

AU - Moerland, Marinus A

AU - Noteboom, Juus L

AU - Eppinga, Wietse S

AU - Davila Fajardo, Raquel

AU - Lagendijk, Jan

AU - Van der Voort van Zyp, Jochem R

PY - 2018/4/5

Y1 - 2018/4/5

N2 - Prostate cancer recurrences are common, even with twenty-first-century primary prostate cancer treatment modalities. The most common salvage treatment is (delayed) hormonal therapy, which is often associated with serious side-effects. Due to the risk of significant toxicity, whole-gland targeted salvage treatments remain unpopular. Consequently, developments in focal therapies have arisen. Magnetic resonance imaging (MRI)-guided focal salvage high-dose-rate brachytherapy (HDR-BT) is a novel treatment aiming for minimal toxicity in recurrent prostate cancer patients. Repeating focal treatment could, therefore, be possible in case of post-salvage recurrence. We report the case of a 77-year-old man who underwent repeat focal HDR-BT.

AB - Prostate cancer recurrences are common, even with twenty-first-century primary prostate cancer treatment modalities. The most common salvage treatment is (delayed) hormonal therapy, which is often associated with serious side-effects. Due to the risk of significant toxicity, whole-gland targeted salvage treatments remain unpopular. Consequently, developments in focal therapies have arisen. Magnetic resonance imaging (MRI)-guided focal salvage high-dose-rate brachytherapy (HDR-BT) is a novel treatment aiming for minimal toxicity in recurrent prostate cancer patients. Repeating focal treatment could, therefore, be possible in case of post-salvage recurrence. We report the case of a 77-year-old man who underwent repeat focal HDR-BT.

KW - prostate cancer

KW - recurrence

KW - brachytherapy

KW - salvage therapy

KW - interventional magnetic resonance imaging

U2 - 10.7759/cureus.2429

DO - 10.7759/cureus.2429

M3 - Article

C2 - 29876151

SN - 2168-8184

VL - 10

JO - Cureus

JF - Cureus

IS - 4

M1 - e2429

ER -

Re-salvage MRI-guided Focal High-dose-rate Brachytherapy for Locally Recurrent Prostate Cancer

Abstract

Keywords

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