Rat model to investigate the treatment of acute nitrogen dioxide intoxication

J. Meulenbelt; J. A M A Dormans; M. Marra; P. J A Rombout; B. Sangster

Rat model to investigate the treatment of acute nitrogen dioxide intoxication

J. Meulenbelt^*, J. A M A Dormans, M. Marra, P. J A Rombout, B. Sangster

^*Corresponding author for this work

Clinical Toxicology

Research output: Contribution to journal › Article › Academic › peer-review

5 Citations (Scopus)

Abstract

1. The pulmonary toxic events induced by acute nitrogen dioxide (NO), exposure were studied in the rat to develop an inhalation model to investigate therapeutic measures. 2. A good correlation was observed between the lung weights and severity of the atypical pneumonitis. The pulmonary effects observed, became more pronounced with increasing NO₂ concentrations (0, 25, 75, 125, 175 or 200 ppm, 1 ppm NO₂=1.88 mg m^-3 NO₂) and exposure times (5, 10. 20 or 30 min). 3. An adequate NO₂ concentration is 175 ppm, because it can induce a severe lung injury without mortality. This makes it possible to investigate suitable therapeutic interventions for several days. 4. Following acute inhalatory NO₂ intoxication, transformation of NO₂ to nitrate is presumably more notable than transformation to nitrite. 5. The transformation of NO₂ to nitrate in lung tissue causes a slight increase in the serum nitrite concentration, which does not induce measurable formation of methaemoglobin. 6. Presumably, methaemoglobin does not contribute to the toxicity of NO₂ intoxication.

Original language	English
Pages (from-to)	179-187
Number of pages	9
Journal	Human Toxicology
Volume	11
Issue number	3
Publication status	Published - 1 Jan 1992

Cite this

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title = "Rat model to investigate the treatment of acute nitrogen dioxide intoxication",

abstract = "1. The pulmonary toxic events induced by acute nitrogen dioxide (NO), exposure were studied in the rat to develop an inhalation model to investigate therapeutic measures. 2. A good correlation was observed between the lung weights and severity of the atypical pneumonitis. The pulmonary effects observed, became more pronounced with increasing NO2 concentrations (0, 25, 75, 125, 175 or 200 ppm, 1 ppm NO2=1.88 mg m-3 NO2) and exposure times (5, 10. 20 or 30 min). 3. An adequate NO2 concentration is 175 ppm, because it can induce a severe lung injury without mortality. This makes it possible to investigate suitable therapeutic interventions for several days. 4. Following acute inhalatory NO2 intoxication, transformation of NO2 to nitrate is presumably more notable than transformation to nitrite. 5. The transformation of NO2 to nitrate in lung tissue causes a slight increase in the serum nitrite concentration, which does not induce measurable formation of methaemoglobin. 6. Presumably, methaemoglobin does not contribute to the toxicity of NO2 intoxication.",

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AU - Meulenbelt, J.

AU - Dormans, J. A M A

AU - Marra, M.

AU - Rombout, P. J A

AU - Sangster, B.

PY - 1992/1/1

Y1 - 1992/1/1

N2 - 1. The pulmonary toxic events induced by acute nitrogen dioxide (NO), exposure were studied in the rat to develop an inhalation model to investigate therapeutic measures. 2. A good correlation was observed between the lung weights and severity of the atypical pneumonitis. The pulmonary effects observed, became more pronounced with increasing NO2 concentrations (0, 25, 75, 125, 175 or 200 ppm, 1 ppm NO2=1.88 mg m-3 NO2) and exposure times (5, 10. 20 or 30 min). 3. An adequate NO2 concentration is 175 ppm, because it can induce a severe lung injury without mortality. This makes it possible to investigate suitable therapeutic interventions for several days. 4. Following acute inhalatory NO2 intoxication, transformation of NO2 to nitrate is presumably more notable than transformation to nitrite. 5. The transformation of NO2 to nitrate in lung tissue causes a slight increase in the serum nitrite concentration, which does not induce measurable formation of methaemoglobin. 6. Presumably, methaemoglobin does not contribute to the toxicity of NO2 intoxication.

AB - 1. The pulmonary toxic events induced by acute nitrogen dioxide (NO), exposure were studied in the rat to develop an inhalation model to investigate therapeutic measures. 2. A good correlation was observed between the lung weights and severity of the atypical pneumonitis. The pulmonary effects observed, became more pronounced with increasing NO2 concentrations (0, 25, 75, 125, 175 or 200 ppm, 1 ppm NO2=1.88 mg m-3 NO2) and exposure times (5, 10. 20 or 30 min). 3. An adequate NO2 concentration is 175 ppm, because it can induce a severe lung injury without mortality. This makes it possible to investigate suitable therapeutic interventions for several days. 4. Following acute inhalatory NO2 intoxication, transformation of NO2 to nitrate is presumably more notable than transformation to nitrite. 5. The transformation of NO2 to nitrate in lung tissue causes a slight increase in the serum nitrite concentration, which does not induce measurable formation of methaemoglobin. 6. Presumably, methaemoglobin does not contribute to the toxicity of NO2 intoxication.

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VL - 11

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JO - Human Toxicology

JF - Human Toxicology

IS - 3

ER -

Rat model to investigate the treatment of acute nitrogen dioxide intoxication

Abstract

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