Rat genetics: the next episode

Bart M.G. Smits*, Edwin Cuppen

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

17 Citations (Scopus)


More than a thousand quantitative trait loci (QTLs) relevant to many aspects of complex human disease have been identified in a wide range of rat inbred lines over the past few decades. With the complete rat genome available, it is now time for the next stage in rat genetic research: the identification and causal confirmation of underlying polymorphisms and genes. Recent developments in single nucleotide polymorphism-based genetic markers and technologies to manipulate the rat genome will undoubtedly be important tools in this next episode.

Original languageEnglish
Pages (from-to)232-240
Number of pages9
JournalTrends in Genetics
Issue number4
Publication statusPublished - 1 Apr 2006


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