Rapid accumulation of nonnucleoside reverse transcriptase inhibitor-associated resistance: evidence of transmitted resistance in rural South Africa

R.E. Barth, A.M.J. Wensing, H.A. Tempelman, R. Moraba, R. Schuurman, I.M. Hoepelman

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

In a large cohort in rural South Africa, 73% of subtype-C-infected patients initiating highly active antiretroviral therapy achieved viral suppression. In patients with subsequent virological failure, an unexpected, rapid accumulation of nonnucleoside reverse transcriptase inhibitor-associated mutations was observed, whereas no thymidine analogue-associated mutations emerged. It appeared that several patients had drug-associated mutations prior to starting antiretrovirals, suggesting that transmission of resistance may have contributed to the accumulation of nonnucleoside reverse transcriptase inhibitor-mutations. Importantly, monitoring of HIV-RNA and prompt switch of treatment may prevent development of thymidine analogue-associated mutations.

Original languageEnglish
Pages (from-to)2210-2
Number of pages3
JournalAIDS
Volume22
Issue number16
DOIs
Publication statusPublished - 2008

Keywords

  • Anti-HIV Agents
  • Antiretroviral Therapy, Highly Active
  • Drug Resistance, Viral
  • HIV Infections
  • HIV-1
  • Humans
  • Longitudinal Studies
  • Mutation
  • Reverse Transcriptase Inhibitors
  • Rural Health
  • South Africa

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