Rap signaling

Willem Jan Pannekoek; Johannes L. Bos

doi:10.1007/978-3-7091-1806-1_11

Rap signaling

Willem Jan Pannekoek, Johannes L. Bos^*

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review

Abstract

The Rap proteins comprise a subfamily of the Ras-like small G-proteins, most closely related to Ras, which were originally found to antagonize Ras-induced cell transformation. Rap transduces extracellular stimuli to a variety of different processes, amongst others cell-matrix adhesion, cell-cell adhesion, and actin dynamics. Here, we present an overview of the mechanisms that regulate activation, including guanine nucleotide exchange factors and GTPase activating proteins responsible for the regulation. We discuss the various biological functions that are controlled by Rap proteins and the molecular mechanism used by Rap1 to induce these responses.

Original language	English
Title of host publication	Ras Superfamily Small G Proteins
Subtitle of host publication	Biology and Mechanisms 1: General Features, Signaling
Publisher	Springer-Verlag Wien
Pages	233-255
Number of pages	23
ISBN (Electronic)	9783709118061
ISBN (Print)	3709118050, 9783709118054
DOIs	https://doi.org/10.1007/978-3-7091-1806-1_11
Publication status	Published - 1 May 2014

Keywords

Rap1
Rap2

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10.1007/978-3-7091-1806-1_11

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AU - Bos, Johannes L.

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AB - The Rap proteins comprise a subfamily of the Ras-like small G-proteins, most closely related to Ras, which were originally found to antagonize Ras-induced cell transformation. Rap transduces extracellular stimuli to a variety of different processes, amongst others cell-matrix adhesion, cell-cell adhesion, and actin dynamics. Here, we present an overview of the mechanisms that regulate activation, including guanine nucleotide exchange factors and GTPase activating proteins responsible for the regulation. We discuss the various biological functions that are controlled by Rap proteins and the molecular mechanism used by Rap1 to induce these responses.

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KW - Rap2

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PB - Springer-Verlag Wien

ER -

Rap signaling

Abstract

Keywords

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