Radiomics in Hypopharyngeal Cancer Management: A State-of-the-Art Review

Carlos M Chiesa-Estomba*, Miguel Mayo-Yanez, Orlando Guntinas-Lichius, Vincent Vander-Poorten, Robert P Takes, Remco de Bree, Gyorgy B Halmos, Nabil F Saba, Sandra Nuyts, Alfio Ferlito

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

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Abstract

(1) Background: Hypopharyngeal squamous cell carcinomas usually present with locally advanced disease and a correspondingly poor prognosis. Currently, efforts are being made to improve tumor characterization and provide insightful information for outcome prediction. Radiomics is an emerging area of study that involves the conversion of medical images into mineable data; these data are then used to extract quantitative features based on shape, intensity, texture, and other parameters; (2) Methods: A systematic review of the peer-reviewed literature was conducted; (3) Results: A total of 437 manuscripts were identified. Fifteen manuscripts met the inclusion criteria. The main targets described were the evaluation of textural features to determine tumor-programmed death-ligand 1 expression; a surrogate for microvessel density and heterogeneity of perfusion; patient stratification into groups at high and low risk of progression; prediction of early recurrence, 1-year locoregional failure and survival outcome, including progression-free survival and overall survival, in patients with locally advanced HPSCC; thyroid cartilage invasion, early disease progression, recurrence, induction chemotherapy response, treatment response, and prognosis; and (4) Conclusions: our findings suggest that radiomics represents a potentially useful tool in the diagnostic workup as well as during the treatment and follow-up of patients with HPSCC. Large prospective studies are essential to validate this technology in these patients.

Original languageEnglish
Article number805
Number of pages13
JournalBiomedicines
Volume11
Issue number3
DOIs
Publication statusPublished - 6 Mar 2023

Keywords

  • head
  • hypopharynx
  • neck
  • radiomics
  • treatment

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