Radioguided Sentinel Lymph Node Mapping and Biopsy in Oral Cancer

Remco De Bree; Christina Bluemel

doi:10.1007/978-3-319-26051-8_11

Radioguided Sentinel Lymph Node Mapping and Biopsy in Oral Cancer

Remco De Bree^*, Christina Bluemel

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review

Abstract

Oral cancer is one of the most common head and neck malignancies. As lymph node metastases are one of the most important prognostic factors, an elective neck dissection (END) has been widely performed for accurate staging of the cervical lymph nodes. However, up to 75 % of patients are overtreated and may suffer from side effects of END. In 2001, the first results and advantages of sentinel lymph node biopsy (SLNB) as an alternative for neck staging in clinically node negative patients with oral cancer were firstly discussed in an international conference. The high detection rate, sensitivity, and low false-negative rate of SLNB was demonstrated in multicenter studies. However, due to the complex lymphatic drainage and close vicinity of the injection site, SLNB in head and neck is challenging. The development of new tracers and technologies might facilitate the intraoperative detection of SLNs and improve results of SLNB.

Original language	English
Title of host publication	Radioguided Surgery
Subtitle of host publication	Current Applications and Innovative Directions in Clinical Practice
Publisher	Springer
Pages	167-179
Number of pages	13
ISBN (Electronic)	9783319260518
ISBN (Print)	9783319260495
DOIs	https://doi.org/10.1007/978-3-319-26051-8_11
Publication status	Published - 1 Jan 2016

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abstract = "Oral cancer is one of the most common head and neck malignancies. As lymph node metastases are one of the most important prognostic factors, an elective neck dissection (END) has been widely performed for accurate staging of the cervical lymph nodes. However, up to 75 % of patients are overtreated and may suffer from side effects of END. In 2001, the first results and advantages of sentinel lymph node biopsy (SLNB) as an alternative for neck staging in clinically node negative patients with oral cancer were firstly discussed in an international conference. The high detection rate, sensitivity, and low false-negative rate of SLNB was demonstrated in multicenter studies. However, due to the complex lymphatic drainage and close vicinity of the injection site, SLNB in head and neck is challenging. The development of new tracers and technologies might facilitate the intraoperative detection of SLNs and improve results of SLNB.",

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AB - Oral cancer is one of the most common head and neck malignancies. As lymph node metastases are one of the most important prognostic factors, an elective neck dissection (END) has been widely performed for accurate staging of the cervical lymph nodes. However, up to 75 % of patients are overtreated and may suffer from side effects of END. In 2001, the first results and advantages of sentinel lymph node biopsy (SLNB) as an alternative for neck staging in clinically node negative patients with oral cancer were firstly discussed in an international conference. The high detection rate, sensitivity, and low false-negative rate of SLNB was demonstrated in multicenter studies. However, due to the complex lymphatic drainage and close vicinity of the injection site, SLNB in head and neck is challenging. The development of new tracers and technologies might facilitate the intraoperative detection of SLNs and improve results of SLNB.

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Radioguided Sentinel Lymph Node Mapping and Biopsy in Oral Cancer

Abstract

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