Radiofrequency Ablation of the Atherosclerotic Plaque: a Proof of Concept Study in an Atherosclerotic Model

Guilielmus H J M Ellenbroek; Gerardus P J van Hout; Saskia C A de Jager; Leo Timmers; Aryan Vink; Roel Goldschmeding; Petra van der Kraak; Gerard Pasterkamp; Imo E Hoefer; Petrus A Doevendans; Yolande Appelman

doi:10.1007/s12265-017-9743-3

Radiofrequency Ablation of the Atherosclerotic Plaque: a Proof of Concept Study in an Atherosclerotic Model

Guilielmus H J M Ellenbroek, Gerardus P J van Hout, Saskia C A de Jager, Leo Timmers, Aryan Vink, Roel Goldschmeding, Petra van der Kraak, Gerard Pasterkamp, Imo E Hoefer, Petrus A Doevendans, Yolande Appelman

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Increased plaque vascularization is causatively associated with the progression of unstable atherosclerotic vessel disease. We investigated the safety and efficacy of heat-generating radiofrequency ablation (RFA) in reducing the number of vessels in the plaque and adventitia and its effect on plaque size and composition. To this end, New Zealand White rabbits were fed a cholesterol-enriched diet and subjected to balloon denudation of the infrarenal aorta to induce atherosclerotic plaque formation. After 13 weeks, the proximal or distal half of the infrarenal aorta was exposed to transluminal RFA. The untreated half served as an intra-individual control. Optical coherence tomography (OCT) was performed directly after RFA. We found that RFA on the rabbit atherosclerotic plaque is safe and leads to decreased intraplaque vessel density and smooth muscle cell content but does not affect other components of plaque composition or size.

Original language	English
Pages (from-to)	221–232
Number of pages	12
Journal	Journal of Cardiovascular Translational Research
Volume	10
Issue number	2
DOIs	https://doi.org/10.1007/s12265-017-9743-3
Publication status	Published - Apr 2017

Keywords

Radiofrequency ablation
Atherosclerosis
Plaque progression
Neovascularization
Vasa vasorum
Smooth muscle cell
Smooth muscle cell
Neovascularization, Pathologic
Catheter Ablation
Male
Muscle, Smooth, Vascular/pathology
Time Factors
Diet, High-Fat
Myocytes, Smooth Muscle/pathology
Angioplasty, Balloon
Atherosclerosis/diagnostic imaging
Disease Models, Animal
Rabbits
Tomography, Optical Coherence
Aortic Diseases/diagnostic imaging
Plaque, Atherosclerotic
Proof of Concept Study
Animals
Aorta, Abdominal/diagnostic imaging
Aortography
Cholesterol, Dietary

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Ellenbroek, G. H. J. M., van Hout, G. P. J., de Jager, S. C. A., Timmers, L., Vink, A., Goldschmeding, R., van der Kraak, P., Pasterkamp, G., Hoefer, I. E., Doevendans, P. A., & Appelman, Y. (2017). Radiofrequency Ablation of the Atherosclerotic Plaque: a Proof of Concept Study in an Atherosclerotic Model. Journal of Cardiovascular Translational Research, 10(2), 221–232. https://doi.org/10.1007/s12265-017-9743-3

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title = "Radiofrequency Ablation of the Atherosclerotic Plaque: a Proof of Concept Study in an Atherosclerotic Model",

abstract = "Increased plaque vascularization is causatively associated with the progression of unstable atherosclerotic vessel disease. We investigated the safety and efficacy of heat-generating radiofrequency ablation (RFA) in reducing the number of vessels in the plaque and adventitia and its effect on plaque size and composition. To this end, New Zealand White rabbits were fed a cholesterol-enriched diet and subjected to balloon denudation of the infrarenal aorta to induce atherosclerotic plaque formation. After 13 weeks, the proximal or distal half of the infrarenal aorta was exposed to transluminal RFA. The untreated half served as an intra-individual control. Optical coherence tomography (OCT) was performed directly after RFA. We found that RFA on the rabbit atherosclerotic plaque is safe and leads to decreased intraplaque vessel density and smooth muscle cell content but does not affect other components of plaque composition or size.",

keywords = "Radiofrequency ablation, Atherosclerosis, Plaque progression, Neovascularization, Vasa vasorum, Smooth muscle cell , Smooth muscle cell, Neovascularization, Pathologic, Catheter Ablation, Male, Muscle, Smooth, Vascular/pathology, Time Factors, Diet, High-Fat, Myocytes, Smooth Muscle/pathology, Angioplasty, Balloon, Atherosclerosis/diagnostic imaging, Disease Models, Animal, Rabbits, Tomography, Optical Coherence, Aortic Diseases/diagnostic imaging, Plaque, Atherosclerotic, Proof of Concept Study, Animals, Aorta, Abdominal/diagnostic imaging, Aortography, Cholesterol, Dietary",

author = "Ellenbroek, {Guilielmus H J M} and {van Hout}, {Gerardus P J} and {de Jager}, {Saskia C A} and Leo Timmers and Aryan Vink and Roel Goldschmeding and {van der Kraak}, Petra and Gerard Pasterkamp and Hoefer, {Imo E} and Doevendans, {Petrus A} and Yolande Appelman",

note = "Funding Information: This study is funded by direct governmental funding. Publisher Copyright: {\textcopyright} 2017, The Author(s).",

year = "2017",

month = apr,

doi = "10.1007/s12265-017-9743-3",

language = "English",

volume = "10",

pages = "221–232",

journal = "Journal of Cardiovascular Translational Research",

issn = "1937-5387",

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Ellenbroek, GHJM, van Hout, GPJ, de Jager, SCA, Timmers, L, Vink, A, Goldschmeding, R, van der Kraak, P, Pasterkamp, G, Hoefer, IE, Doevendans, PA & Appelman, Y 2017, 'Radiofrequency Ablation of the Atherosclerotic Plaque: a Proof of Concept Study in an Atherosclerotic Model', Journal of Cardiovascular Translational Research, vol. 10, no. 2, pp. 221–232. https://doi.org/10.1007/s12265-017-9743-3

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T1 - Radiofrequency Ablation of the Atherosclerotic Plaque

T2 - a Proof of Concept Study in an Atherosclerotic Model

AU - Ellenbroek, Guilielmus H J M

AU - van Hout, Gerardus P J

AU - de Jager, Saskia C A

AU - Timmers, Leo

AU - Vink, Aryan

AU - Goldschmeding, Roel

AU - van der Kraak, Petra

AU - Pasterkamp, Gerard

AU - Hoefer, Imo E

AU - Doevendans, Petrus A

AU - Appelman, Yolande

PY - 2017/4

Y1 - 2017/4

N2 - Increased plaque vascularization is causatively associated with the progression of unstable atherosclerotic vessel disease. We investigated the safety and efficacy of heat-generating radiofrequency ablation (RFA) in reducing the number of vessels in the plaque and adventitia and its effect on plaque size and composition. To this end, New Zealand White rabbits were fed a cholesterol-enriched diet and subjected to balloon denudation of the infrarenal aorta to induce atherosclerotic plaque formation. After 13 weeks, the proximal or distal half of the infrarenal aorta was exposed to transluminal RFA. The untreated half served as an intra-individual control. Optical coherence tomography (OCT) was performed directly after RFA. We found that RFA on the rabbit atherosclerotic plaque is safe and leads to decreased intraplaque vessel density and smooth muscle cell content but does not affect other components of plaque composition or size.

AB - Increased plaque vascularization is causatively associated with the progression of unstable atherosclerotic vessel disease. We investigated the safety and efficacy of heat-generating radiofrequency ablation (RFA) in reducing the number of vessels in the plaque and adventitia and its effect on plaque size and composition. To this end, New Zealand White rabbits were fed a cholesterol-enriched diet and subjected to balloon denudation of the infrarenal aorta to induce atherosclerotic plaque formation. After 13 weeks, the proximal or distal half of the infrarenal aorta was exposed to transluminal RFA. The untreated half served as an intra-individual control. Optical coherence tomography (OCT) was performed directly after RFA. We found that RFA on the rabbit atherosclerotic plaque is safe and leads to decreased intraplaque vessel density and smooth muscle cell content but does not affect other components of plaque composition or size.

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KW - Atherosclerosis

KW - Plaque progression

KW - Neovascularization

KW - Vasa vasorum

KW - Smooth muscle cell

KW - Neovascularization, Pathologic

KW - Catheter Ablation

KW - Male

KW - Muscle, Smooth, Vascular/pathology

KW - Time Factors

KW - Diet, High-Fat

KW - Myocytes, Smooth Muscle/pathology

KW - Angioplasty, Balloon

KW - Atherosclerosis/diagnostic imaging

KW - Disease Models, Animal

KW - Rabbits

KW - Tomography, Optical Coherence

KW - Aortic Diseases/diagnostic imaging

KW - Plaque, Atherosclerotic

KW - Proof of Concept Study

KW - Animals

KW - Aorta, Abdominal/diagnostic imaging

KW - Aortography

KW - Cholesterol, Dietary

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U2 - 10.1007/s12265-017-9743-3

DO - 10.1007/s12265-017-9743-3

M3 - Article

C2 - 28364193

SN - 1937-5387

VL - 10

SP - 221

EP - 232

JO - Journal of Cardiovascular Translational Research

JF - Journal of Cardiovascular Translational Research

IS - 2

ER -

Radiofrequency Ablation of the Atherosclerotic Plaque: a Proof of Concept Study in an Atherosclerotic Model

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Keywords

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