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Radiation-Induced Giant Cell Granuloma Mimicking Relapsed Hodgkin Lymphoma at FDG-PET/CT

  • Hugo J.A. Adams*
  • , John M. H. de Klerk
  • , Josien C. Regelink
  • , Ben G. F. Heggelman
  • , Stefan V. Dubois
  • , Thomas C. Kwee
  • *Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

A 22-year-old woman was diagnosed with intermediate risk stage II Hodgkin lymphoma and treated with three cycles of adriamycin, bleomycin, vinblastine, and dacarbazine (ABVD) followed by involved-field radiation therapy. A complete metabolic remission was achieved after two cycles of ABVD, which was maintained until three years after completion of treatment. Follow-up FDG-PET/CT four years after completion of treatment, however, showed a new FDG-avid (Deauville score of 4) lesion in the right scapula, suggesting relapsed disease. Computer tomography (CT)-guided biopsy of this lesion was performed and subsequent histological examination revealed a radiation-induced giant cell granuloma.

Original languageEnglish
Pages (from-to)371-373
Number of pages3
JournalNuclear Medicine and Molecular Imaging
Volume51
Issue number4
DOIs
Publication statusPublished - 1 Dec 2017

Keywords

  • Biopsy
  • FDG-PET/CT
  • Giant cell granuloma
  • Hodgkin lymphoma

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