TY - JOUR
T1 - Quantitative evaluation of myocardial perfusion in patients with revascularized myocardial infarction
T2 - Comparison between intravenous myocardial contrast echocardiography and 99mTc-sestamibi single photon emission computed tomography
AU - Sieswerda, Gertjan Tj
AU - Klein, Lucas J.
AU - Kamp, Otto
AU - Aiazian, Eric A.
AU - Lepper, Wolfgang
AU - Visser, Frans C.
AU - Hanrath, Peter
AU - Visser, Cees A.
PY - 2004/1
Y1 - 2004/1
N2 - Aims. This two-center study compared quantitative segmental perfusion mapping by intravenous myocardial contrast echocardiography (ivMCE) and scintigraphy (SPECT) in patients in the subacute phase of myocardial infarction (AMI). Methods and results. Sixteen patients underwent ivMCE using 1 : 1 intermittent harmonic imaging 24 h after first AMI treated with PTCA and stenting. Apical contrast echocardiograms were obtained after the injections of Sonazoid™. Baseline-corrected peak myocardial videointensity (bcPMVI) was determined automatically in 16 segments. Resting 99mTc-sestamibi SPECT was performed within one day after ivMCE. SPECT images were reoriented matching the ivMCE views, and divided into the same segments as in ivMCE, from which mean count rate values were obtained. After exclusion due to artifacts or attenuation, 208/256 (82%) segments remained for analysis. Normalized SPECT count rate and bcPMVI correlated linearly: bcPMVI = 1.237×SPECT - 35; r = 0.74, p<0.0001. The relation remained identical in subgroup analysis based on participating center, echocardiographic view, perfusion territory, infarct zone, or function. Using SPECT as reference, mean bcPMVI was 77±19% in normal segments, 53±29% in mild-moderate defects and 25±18% in severe defects (p<0.001 for all comparisons). Conclusion. The videointensity increase observed in quantitative ivMCE clearly correlated with SPECT tracer uptake. This further substantiates the use of ivMCE as a valid technique for myocardial perfusion imaging.
AB - Aims. This two-center study compared quantitative segmental perfusion mapping by intravenous myocardial contrast echocardiography (ivMCE) and scintigraphy (SPECT) in patients in the subacute phase of myocardial infarction (AMI). Methods and results. Sixteen patients underwent ivMCE using 1 : 1 intermittent harmonic imaging 24 h after first AMI treated with PTCA and stenting. Apical contrast echocardiograms were obtained after the injections of Sonazoid™. Baseline-corrected peak myocardial videointensity (bcPMVI) was determined automatically in 16 segments. Resting 99mTc-sestamibi SPECT was performed within one day after ivMCE. SPECT images were reoriented matching the ivMCE views, and divided into the same segments as in ivMCE, from which mean count rate values were obtained. After exclusion due to artifacts or attenuation, 208/256 (82%) segments remained for analysis. Normalized SPECT count rate and bcPMVI correlated linearly: bcPMVI = 1.237×SPECT - 35; r = 0.74, p<0.0001. The relation remained identical in subgroup analysis based on participating center, echocardiographic view, perfusion territory, infarct zone, or function. Using SPECT as reference, mean bcPMVI was 77±19% in normal segments, 53±29% in mild-moderate defects and 25±18% in severe defects (p<0.001 for all comparisons). Conclusion. The videointensity increase observed in quantitative ivMCE clearly correlated with SPECT tracer uptake. This further substantiates the use of ivMCE as a valid technique for myocardial perfusion imaging.
KW - Contrast echocardiography
KW - Microcirculation
KW - Myocardial perfusion
KW - Scintigraphy
UR - http://www.scopus.com/inward/record.url?scp=1242319578&partnerID=8YFLogxK
U2 - 10.1016/j.euje.2003.08.005
DO - 10.1016/j.euje.2003.08.005
M3 - Article
C2 - 15113011
AN - SCOPUS:1242319578
SN - 1525-2167
VL - 5
SP - 41
EP - 50
JO - European Journal of Echocardiography
JF - European Journal of Echocardiography
IS - 1
ER -