Quantitative DTI measures

Kathleen M. Curran; Louise Emsell; Alexander Leemans

doi:10.1007/978-1-4939-3118-7_5

Quantitative DTI measures

Kathleen M. Curran^*, Louise Emsell, Alexander Leemans

^*Corresponding author for this work

Brain

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review

Abstract

Diffusion tensor imaging (DTI) has revolutionized the visualization of white matter in vivo. However, it is far more than a qualitative tool and can also be used to generate quantitative measures related to diffusion magnitude and its degree of anisotropy, which indirectly reflect microstructural organisation. Although highly sensitive to microstructural change, DTI measures lack specificity and are influenced by a wide range of biological and methodological factors. This makes the interpretation of DTI metric changes extremely challenging.

This chapter introduces the most common DTI measures and how they relate to tissue microstructure. Important confounds are addressed, including how DTI metrics are influenced by biological factors such as ageing and pathology, and by methodological factors such as data acquisition, modeling, and analysis.

Original language	English
Title of host publication	Diffusion Tensor Imaging
Subtitle of host publication	A Practical Handbook
Editors	Wim van Hecke, Louise Emsell, Stefan Sunaert
Publisher	Springer New York
Pages	65-87
Number of pages	23
ISBN (Electronic)	9781493931187
ISBN (Print)	9781493931170
DOIs	https://doi.org/10.1007/978-1-4939-3118-7_5
Publication status	Published - 1 Jan 2016

Keywords

Diffusion parameters
Visualization
Axial and radial diffusivity
Relationship to neurobiology

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10.1007/978-1-4939-3118-7_5

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AU - Leemans, Alexander

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AB - Diffusion tensor imaging (DTI) has revolutionized the visualization of white matter in vivo. However, it is far more than a qualitative tool and can also be used to generate quantitative measures related to diffusion magnitude and its degree of anisotropy, which indirectly reflect microstructural organisation. Although highly sensitive to microstructural change, DTI measures lack specificity and are influenced by a wide range of biological and methodological factors. This makes the interpretation of DTI metric changes extremely challenging.This chapter introduces the most common DTI measures and how they relate to tissue microstructure. Important confounds are addressed, including how DTI metrics are influenced by biological factors such as ageing and pathology, and by methodological factors such as data acquisition, modeling, and analysis.

KW - Diffusion parameters

KW - Visualization

KW - Axial and radial diffusivity

KW - Relationship to neurobiology

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M3 - Chapter

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A2 - Emsell, Louise

A2 - Sunaert, Stefan

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Quantitative DTI measures

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