TY - JOUR
T1 - Quantifying [18F]fluorodeoxyglucose uptake in the arterial wall
T2 - the effects of dual time-point imaging and partial volume effect correction
AU - Blomberg, Björn A.
AU - Bashyam, Arjun
AU - Ramachandran, Abhinay
AU - Gholami, Saeid
AU - Houshmand, Sina
AU - Salavati, Ali
AU - Werner, Tom
AU - Zaidi, Habib
AU - Alavi, Abass
PY - 2015/8/24
Y1 - 2015/8/24
N2 - Purpose: The human arterial wall is smaller than the spatial resolution of current positron emission tomographs. Therefore, partial volume effects should be considered when quantifying arterial wall 18F-FDG uptake. We evaluated the impact of a novel method for partial volume effect (PVE) correction with contrast-enhanced CT (CECT) assistance on quantification of arterial wall 18F-FDG uptake at different imaging time-points. Methods: Ten subjects were assessed by CECT imaging and dual time-point PET/CT imaging at approximately 60 and 180 min after 18F-FDG administration. For both time-points, uptake of 18F-FDG was determined in the aortic wall by calculating the blood pool-corrected maximum standardized uptake value (cSUVMAX) and cSUVMEAN. The PVE-corrected SUVMEAN (pvcSUVMEAN) was also calculated using 18F-FDG PET/CT and CECT images. Finally, corresponding target-to-background ratios (TBR) were calculated. Results: At 60 min, pvcSUVMEAN was on average 3.1 times greater than cSUVMAX (P <.0001) and 8.5 times greater than cSUVMEAN (P <.0001). At 180 min, pvcSUVMEAN was on average 2.6 times greater than cSUVMAX (P <.0001) and 6.6 times greater than cSUVMEAN (P <.0001). Conclusion: This study demonstrated that CECT-assisted PVE correction significantly influences quantification of arterial wall 18F-FDG uptake. Therefore, partial volume effects should be considered when quantifying arterial wall 18F-FDG uptake with PET.
AB - Purpose: The human arterial wall is smaller than the spatial resolution of current positron emission tomographs. Therefore, partial volume effects should be considered when quantifying arterial wall 18F-FDG uptake. We evaluated the impact of a novel method for partial volume effect (PVE) correction with contrast-enhanced CT (CECT) assistance on quantification of arterial wall 18F-FDG uptake at different imaging time-points. Methods: Ten subjects were assessed by CECT imaging and dual time-point PET/CT imaging at approximately 60 and 180 min after 18F-FDG administration. For both time-points, uptake of 18F-FDG was determined in the aortic wall by calculating the blood pool-corrected maximum standardized uptake value (cSUVMAX) and cSUVMEAN. The PVE-corrected SUVMEAN (pvcSUVMEAN) was also calculated using 18F-FDG PET/CT and CECT images. Finally, corresponding target-to-background ratios (TBR) were calculated. Results: At 60 min, pvcSUVMEAN was on average 3.1 times greater than cSUVMAX (P <.0001) and 8.5 times greater than cSUVMEAN (P <.0001). At 180 min, pvcSUVMEAN was on average 2.6 times greater than cSUVMAX (P <.0001) and 6.6 times greater than cSUVMEAN (P <.0001). Conclusion: This study demonstrated that CECT-assisted PVE correction significantly influences quantification of arterial wall 18F-FDG uptake. Therefore, partial volume effects should be considered when quantifying arterial wall 18F-FDG uptake with PET.
KW - Arterial wall
KW - Dual time-point imaging
KW - Partial volume effect correction
KW - PET/CT
KW - [<sup>18</sup>F]Fluorodeoxyglucose
UR - https://www.scopus.com/pages/publications/84937818470
U2 - 10.1007/s00259-015-3074-x
DO - 10.1007/s00259-015-3074-x
M3 - Article
C2 - 25962589
AN - SCOPUS:84937818470
SN - 1619-7070
VL - 42
SP - 1414
EP - 1422
JO - European Journal of Nuclear Medicine and Molecular Imaging
JF - European Journal of Nuclear Medicine and Molecular Imaging
IS - 9
ER -