TY - JOUR
T1 - Quantification of renal and diaphragmatic interfractional motion in pediatric image-guided radiation therapy
T2 - A multicenter study
AU - Huijskens, Sophie C.
AU - van Dijk, Irma W.E.M.
AU - de Jong, Rianne
AU - Visser, Jorrit
AU - Fajardo, Raquel Dávila
AU - Ronckers, Cécile M.
AU - Janssens, G.O.R.J.
AU - Maduro, John H.
AU - Rasch, Coen R.N.
AU - Alderliesten, Tanja
AU - Bel, Arjan
N1 - Funding Information:
We thank the foundation Kinderen Kankervrij (KiKa; project no. 162) for financial support of this work. Dr. Ronckers receives funding from the Dutch Cancer Society .
Publisher Copyright:
© 2015 Elsevier Ireland Ltd
PY - 2015/12/1
Y1 - 2015/12/1
N2 - Background and purpose To quantify renal and diaphragmatic interfractional motion in order to estimate systematic and random errors, and to investigate the correlation between interfractional motion and patient-specific factors. Material and methods We used 527 retrospective abdominal-thoracic cone beam CT scans of 39 childhood cancer patients (<18 years) to quantify renal motion relative to bony anatomy in the left–right (LR), cranio–caudal (CC) and anterior–posterior (AP) directions, and diaphragmatic motion in the CC direction only. Interfractional motion was quantified by distributions of systematic and random errors in each direction (standard deviations Σ and σ, respectively). Also, correlation between organ motion and height was analyzed. Results Inter-patient organ motion varied widely, with the largest movements in the CC direction. Values of Σ in LR, CC, and AP directions were 1.1, 3.8, 2.1 mm for the right, and 1.3, 3.0, 1.5 mm for the left kidney, respectively. The σ in these three directions was 1.1, 3.1, 1.7 mm for the right, and 1.2, 2.9, 2.1 mm for the left kidney, respectively. For the diaphragm we estimated Σ = 5.2 mm and σ = 4.0 mm. No correlations were found between organ motion and height. Conclusions The large inter-patient organ motion variations and the lack of correlation between motion and patient-related factors, suggest that individualized margin approaches might be required.
AB - Background and purpose To quantify renal and diaphragmatic interfractional motion in order to estimate systematic and random errors, and to investigate the correlation between interfractional motion and patient-specific factors. Material and methods We used 527 retrospective abdominal-thoracic cone beam CT scans of 39 childhood cancer patients (<18 years) to quantify renal motion relative to bony anatomy in the left–right (LR), cranio–caudal (CC) and anterior–posterior (AP) directions, and diaphragmatic motion in the CC direction only. Interfractional motion was quantified by distributions of systematic and random errors in each direction (standard deviations Σ and σ, respectively). Also, correlation between organ motion and height was analyzed. Results Inter-patient organ motion varied widely, with the largest movements in the CC direction. Values of Σ in LR, CC, and AP directions were 1.1, 3.8, 2.1 mm for the right, and 1.3, 3.0, 1.5 mm for the left kidney, respectively. The σ in these three directions was 1.1, 3.1, 1.7 mm for the right, and 1.2, 2.9, 2.1 mm for the left kidney, respectively. For the diaphragm we estimated Σ = 5.2 mm and σ = 4.0 mm. No correlations were found between organ motion and height. Conclusions The large inter-patient organ motion variations and the lack of correlation between motion and patient-related factors, suggest that individualized margin approaches might be required.
KW - IGRT
KW - Organ motion
KW - Pediatric RT
KW - Systematic and random errors
UR - http://www.scopus.com/inward/record.url?scp=84945583808&partnerID=8YFLogxK
U2 - 10.1016/j.radonc.2015.09.020
DO - 10.1016/j.radonc.2015.09.020
M3 - Article
C2 - 26433905
AN - SCOPUS:84945583808
SN - 0167-8140
VL - 117
SP - 425
EP - 431
JO - Radiotherapy and Oncology
JF - Radiotherapy and Oncology
IS - 3
ER -