Abstract
Purpose
To compare quality of vision and vision‐related quality of life (VRQOL) following UT‐DSAEK and DMEK.
Patients and Methods
Fifty‐four eyes of 54 patients with Fuchs Endothelial Dystrophy were randomized to either DMEK (n = 29) or UT‐DSAEK (n = 25) in four tertiary and two secondary hospitals in the Netherlands. Straylight, contrast sensitivity and vision‐related quality of life (VRQOL) were measured using the C‐Quant straylight meter (OCULUS Optikgeräte GmbH, Wetzlar, Germany), CSV‐1000 chart (Vector vision Inc., Greenville, OH, USA) and 25‐item National Eye Institute Visual Functioning Questionnaire (VFQ‐25), respectively. Data were analyzed using the Student's t‐test for differences between groups. Results are shown as means with standard deviation. We considered a two‐sided P value of less than 0.05 statistically significant.
Results
Preoperative straylight measured log(s) = 1.66 ± 0.31, (n = 19) in the DMEK group and log(s) = 1.52 ± 0.24 (n = 17) in the UT‐DSAEK group. Three months after surgery, straylight was significantly lower in DMEK compared to UT‐DSAEK (log(s) = 1.32 ± 0.22, n = 20 vs log(s) = 1.48 ± 0.24, n = 18; p = 0.03), but was comparable thereafter. Preoperative contrast sensitivity measured log(cs) = 0.71 ± 0.25 (n = 29) in the DMEK group and log(cs) = 0.65 ± 0.24 (n = 25) in the UT‐DSAEK group. Three months after surgery, contrast sensitivity was significantly better after DMEK compared to UT‐DSAEK (log(cs) = 1.22 ± 0.34, n = 27 vs log(cs) = 0.97 ± 0.3, n = 22; p = 0.01, but was comparable thereafter. Composite score of the VFQ‐25 questionnaire measured 69 ± 14 (n = 27) in the DMEK group and 69 ± 13 (n = 23) in the UT‐DSAEK group preoperatively. Three months after surgery, composite score was comparable between DMEK and UT‐DSAEK (80 ± 11, n = 29 vs 78 ± 15, n = 24; p = 0.49), stabilizing thereafter in both groups.
Conclusions
DMEK results in faster recovery of contrast sensitivity and straylight compared to UT‐DSAEK. However, six month after surgery straylight and contrast sensitivity are comparable between both techniques. Vision‐related quality of life is comparable between both techniques at all time‐points.
To compare quality of vision and vision‐related quality of life (VRQOL) following UT‐DSAEK and DMEK.
Patients and Methods
Fifty‐four eyes of 54 patients with Fuchs Endothelial Dystrophy were randomized to either DMEK (n = 29) or UT‐DSAEK (n = 25) in four tertiary and two secondary hospitals in the Netherlands. Straylight, contrast sensitivity and vision‐related quality of life (VRQOL) were measured using the C‐Quant straylight meter (OCULUS Optikgeräte GmbH, Wetzlar, Germany), CSV‐1000 chart (Vector vision Inc., Greenville, OH, USA) and 25‐item National Eye Institute Visual Functioning Questionnaire (VFQ‐25), respectively. Data were analyzed using the Student's t‐test for differences between groups. Results are shown as means with standard deviation. We considered a two‐sided P value of less than 0.05 statistically significant.
Results
Preoperative straylight measured log(s) = 1.66 ± 0.31, (n = 19) in the DMEK group and log(s) = 1.52 ± 0.24 (n = 17) in the UT‐DSAEK group. Three months after surgery, straylight was significantly lower in DMEK compared to UT‐DSAEK (log(s) = 1.32 ± 0.22, n = 20 vs log(s) = 1.48 ± 0.24, n = 18; p = 0.03), but was comparable thereafter. Preoperative contrast sensitivity measured log(cs) = 0.71 ± 0.25 (n = 29) in the DMEK group and log(cs) = 0.65 ± 0.24 (n = 25) in the UT‐DSAEK group. Three months after surgery, contrast sensitivity was significantly better after DMEK compared to UT‐DSAEK (log(cs) = 1.22 ± 0.34, n = 27 vs log(cs) = 0.97 ± 0.3, n = 22; p = 0.01, but was comparable thereafter. Composite score of the VFQ‐25 questionnaire measured 69 ± 14 (n = 27) in the DMEK group and 69 ± 13 (n = 23) in the UT‐DSAEK group preoperatively. Three months after surgery, composite score was comparable between DMEK and UT‐DSAEK (80 ± 11, n = 29 vs 78 ± 15, n = 24; p = 0.49), stabilizing thereafter in both groups.
Conclusions
DMEK results in faster recovery of contrast sensitivity and straylight compared to UT‐DSAEK. However, six month after surgery straylight and contrast sensitivity are comparable between both techniques. Vision‐related quality of life is comparable between both techniques at all time‐points.
| Original language | English |
|---|---|
| Pages (from-to) | 6-6 |
| Journal | Acta Ophthalmologica |
| Volume | 97 |
| Publication status | Published - Mar 2019 |