TY - JOUR
T1 - Quality of life issues in patients with bone metastases
T2 - A systematic review
AU - Rajeswaran, Thenugaa
AU - Wong, Henry C.Y.
AU - Zhang, Elwyn
AU - Kennedy, Samantha K.F.
AU - Gojsevic, Milena
AU - Soliman, Hany
AU - Vassiliou, Vassilios
AU - Rades, Dirk
AU - Bonomo, Pierluigi
AU - Lee, Shing Fung
AU - Chan, Adrian Wai
AU - Rembielak, Agata
AU - Oldenburger, Eva
AU - Maranzano, Ernesto
AU - Pergolizzi, Stefano
AU - Finkelstein, Joel A.
AU - Larouche, Jeremie
AU - Zhang, Na
AU - Zhang, Xiaojing
AU - Marta, Gustavo N.
AU - Yee, Albert J.M.
AU - Yu, Shengji
AU - van der Velden, Joanne M.
AU - van der Linden, Yvette M.
AU - Chow, Edward
N1 - Publisher Copyright:
© 2023, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
PY - 2024/1
Y1 - 2024/1
N2 - Introduction: Bones are frequent sites of metastatic disease, observed in 30–75% of advanced cancer patients. Quality of life (QoL) is an important endpoint in studies evaluating the treatments of bone metastases (BM), and many patient-reported outcome tools are available. The primary objective of this systematic review was to compile a list of QoL issues relevant to BM and its interventions. The secondary objective was to identify common tools used to assess QoL in patients with BM, and the QoL issues they fail to address. Methods: A search was conducted on Ovid MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials databases between 1946 and 27 January 2023 with the keywords “bone metastases”, “quality of life”, and “patient reported outcomes”. Specific QoL issues in original research studies and the QoL tools used were extracted. Results: The review identified the QoL issues most prevalent to BM in the literature. Physical and functional issues observed in patients included pain, interference with ambulation and daily activities, and fatigue. Psychological symptoms, such as helplessness, depression, and anxiety were also common. These issues interfered with patients’ relationships and social activities. Items not mentioned in existing QoL tools were related to newer treatments of BM, such as pain flare, flu-like symptoms, and jaw pain due to osteonecrosis. Conclusions: This systematic review highlights that QoL issues for patients with BM have expanded over time due to advances in BM-directed treatments. If they are relevant, additional treatment-related QoL issues identified need to be validated prospectively by patients and added to current assessment tools.
AB - Introduction: Bones are frequent sites of metastatic disease, observed in 30–75% of advanced cancer patients. Quality of life (QoL) is an important endpoint in studies evaluating the treatments of bone metastases (BM), and many patient-reported outcome tools are available. The primary objective of this systematic review was to compile a list of QoL issues relevant to BM and its interventions. The secondary objective was to identify common tools used to assess QoL in patients with BM, and the QoL issues they fail to address. Methods: A search was conducted on Ovid MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials databases between 1946 and 27 January 2023 with the keywords “bone metastases”, “quality of life”, and “patient reported outcomes”. Specific QoL issues in original research studies and the QoL tools used were extracted. Results: The review identified the QoL issues most prevalent to BM in the literature. Physical and functional issues observed in patients included pain, interference with ambulation and daily activities, and fatigue. Psychological symptoms, such as helplessness, depression, and anxiety were also common. These issues interfered with patients’ relationships and social activities. Items not mentioned in existing QoL tools were related to newer treatments of BM, such as pain flare, flu-like symptoms, and jaw pain due to osteonecrosis. Conclusions: This systematic review highlights that QoL issues for patients with BM have expanded over time due to advances in BM-directed treatments. If they are relevant, additional treatment-related QoL issues identified need to be validated prospectively by patients and added to current assessment tools.
KW - Patient-reported outcome measures
KW - Quality of life
KW - Secondary bone neoplasms
KW - Systematic review
UR - http://www.scopus.com/inward/record.url?scp=85179646958&partnerID=8YFLogxK
U2 - 10.1007/s00520-023-08241-0
DO - 10.1007/s00520-023-08241-0
M3 - Review article
C2 - 38091116
AN - SCOPUS:85179646958
SN - 0941-4355
VL - 32
JO - Supportive Care in Cancer
JF - Supportive Care in Cancer
IS - 1
M1 - 18
ER -