Pyogenic granuloma: An unrecognized cause of gastrointestinal bleeding

Susanne Van Eeden*, G. Johan A. Offerhaus, Folkert H. Morsink, Bastiaan P. Van Rees, Olivier R.C. Busch, Carel J.M. Van Noesel

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

30 Citations (Scopus)


Pyogenic granuloma is a lobular capillary hemangioma that mostly occurs on the skin, but it is also encountered on the mucosal surface of the oral cavity. Only a few cases in other parts of the digestive tract have been reported in Japanese patients. In this report, two Caucasian patients are described, who presented with gastrointestinal bleeding due to the presence of a pyogenic granuloma. One was located in the distal esophagus and could be treated with local excision and laser-photocoagulation therapy. The other one was located in the small intestine and was removed by surgical resection. Although extremely rare, pyogenic granuloma as a cause of gastrointestinal bleeding needs consideration. The lesion is benign, presumably reactive and can be adequately treated by excision or laser photocoagulation. Immunohistochemistry and/or polymerase chain reaction for herpesvirus 8 can reliably distinguish pyogenic granuloma from Kaposi's sarcoma, an important differential diagnosis.

Original languageEnglish
Pages (from-to)590-593
Number of pages4
JournalVirchows Archiv
Issue number6
Publication statusPublished - 1 Jan 2004


  • Esophagus
  • Gastrointestinal bleeding
  • HHV-8
  • Pyogenic granuloma
  • Small intestine


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