Pulmonary aspergillosis caused by a pan-azole-resistant Aspergillus fumigatus in a 10-year-old boy

V.S. Thors; M.B. Bierings; W.J.G. Melchers; P.E. Verweij; T.F.W. Wolfs

doi:10.1097/INF.0b013e3182037879

Pulmonary aspergillosis caused by a pan-azole-resistant Aspergillus fumigatus in a 10-year-old boy

V.S. Thors, M.B. Bierings, W.J.G. Melchers, P.E. Verweij, T.F.W. Wolfs

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

A 10-year-old boy with high-risk acute lymphoblastic leukemia treated with hematopoietic stem-cell transplantation developed pulmonary aspergillosis while receiving prophylactic voriconazole. A transpleural aspirate culture revealed a pan-azole-resistant Aspergillus fumigatus. Treatment with liposomal amphotericin B resulted in complete recovery. As the frequency of azole resistance in A. fumigatus increases, invasive procedures to isolate fungi for species identification and susceptibility testing becomes even more important.

Original language	English
Pages (from-to)	268-270
Number of pages	3
Journal	The Pediatric infectious disease journal
Volume	30
Issue number	3
DOIs	https://doi.org/10.1097/INF.0b013e3182037879
Publication status	Published - 2011

Keywords

Amphotericin B
Antifungal Agents
Aspergillus fumigatus
Azoles
Chemoprevention
Child
Drug Resistance, Multiple, Fungal
Hematopoietic Stem Cell Transplantation
Humans
Male
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Pulmonary Aspergillosis
Pyrimidines
Treatment Outcome
Triazoles
Voriconazole

Access to Document

10.1097/INF.0b013e3182037879

Cite this

@article{9cb7a834935f47ef9b094e67da06617f,

title = "Pulmonary aspergillosis caused by a pan-azole-resistant Aspergillus fumigatus in a 10-year-old boy",

abstract = "A 10-year-old boy with high-risk acute lymphoblastic leukemia treated with hematopoietic stem-cell transplantation developed pulmonary aspergillosis while receiving prophylactic voriconazole. A transpleural aspirate culture revealed a pan-azole-resistant Aspergillus fumigatus. Treatment with liposomal amphotericin B resulted in complete recovery. As the frequency of azole resistance in A. fumigatus increases, invasive procedures to isolate fungi for species identification and susceptibility testing becomes even more important.",

keywords = "Amphotericin B, Antifungal Agents, Aspergillus fumigatus, Azoles, Chemoprevention, Child, Drug Resistance, Multiple, Fungal, Hematopoietic Stem Cell Transplantation, Humans, Male, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Pulmonary Aspergillosis, Pyrimidines, Treatment Outcome, Triazoles, Voriconazole",

author = "V.S. Thors and M.B. Bierings and W.J.G. Melchers and P.E. Verweij and T.F.W. Wolfs",

year = "2011",

doi = "10.1097/INF.0b013e3182037879",

language = "English",

volume = "30",

pages = "268--270",

journal = "The Pediatric infectious disease journal",

issn = "0891-3668",

publisher = "Lippincott Williams \& Wilkins",

number = "3",

}

TY - JOUR

T1 - Pulmonary aspergillosis caused by a pan-azole-resistant Aspergillus fumigatus in a 10-year-old boy

AU - Thors, V.S.

AU - Bierings, M.B.

AU - Melchers, W.J.G.

AU - Verweij, P.E.

AU - Wolfs, T.F.W.

PY - 2011

Y1 - 2011

N2 - A 10-year-old boy with high-risk acute lymphoblastic leukemia treated with hematopoietic stem-cell transplantation developed pulmonary aspergillosis while receiving prophylactic voriconazole. A transpleural aspirate culture revealed a pan-azole-resistant Aspergillus fumigatus. Treatment with liposomal amphotericin B resulted in complete recovery. As the frequency of azole resistance in A. fumigatus increases, invasive procedures to isolate fungi for species identification and susceptibility testing becomes even more important.

AB - A 10-year-old boy with high-risk acute lymphoblastic leukemia treated with hematopoietic stem-cell transplantation developed pulmonary aspergillosis while receiving prophylactic voriconazole. A transpleural aspirate culture revealed a pan-azole-resistant Aspergillus fumigatus. Treatment with liposomal amphotericin B resulted in complete recovery. As the frequency of azole resistance in A. fumigatus increases, invasive procedures to isolate fungi for species identification and susceptibility testing becomes even more important.

KW - Amphotericin B

KW - Antifungal Agents

KW - Aspergillus fumigatus

KW - Azoles

KW - Chemoprevention

KW - Child

KW - Drug Resistance, Multiple, Fungal

KW - Hematopoietic Stem Cell Transplantation

KW - Humans

KW - Male

KW - Precursor Cell Lymphoblastic Leukemia-Lymphoma

KW - Pulmonary Aspergillosis

KW - Pyrimidines

KW - Treatment Outcome

KW - Triazoles

KW - Voriconazole

U2 - 10.1097/INF.0b013e3182037879

DO - 10.1097/INF.0b013e3182037879

M3 - Article

C2 - 21127455

SN - 0891-3668

VL - 30

SP - 268

EP - 270

JO - The Pediatric infectious disease journal

JF - The Pediatric infectious disease journal

IS - 3

ER -

Pulmonary aspergillosis caused by a pan-azole-resistant Aspergillus fumigatus in a 10-year-old boy

Abstract

Keywords

Access to Document

Fingerprint

Cite this