PTX3 predicts severe disease in febrile patients at the emergency department

Martijn D de Kruif; Maarten Limper; Karlien Sierhuis; Jiri F P Wagenaar; C Arnold Spek; Cecilia Garlanda; Alessia Cotena; Alberto Mantovani; Hugo ten Cate; Pieter H Reitsma; Eric C M van Gorp

doi:10.1016/j.jinf.2009.11.010

PTX3 predicts severe disease in febrile patients at the emergency department

Martijn D de Kruif^*, Maarten Limper, Karlien Sierhuis, Jiri F P Wagenaar, C Arnold Spek, Cecilia Garlanda, Alessia Cotena, Alberto Mantovani, Hugo ten Cate, Pieter H Reitsma, Eric C M van Gorp

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

OBJECTIVES: The long pentraxin PTX3 is a promising marker of disease severity in severely ill patients. In order to identify patients warranting critical care as quickly as possible, we investigated the value of PTX3 as a biomarker for disease severity in patients presenting with fever at the emergency department.

METHODS: Levels of PTX3 were measured in 211 febrile patients at the emergency and the levels were linked to markers of disease severity including admittance to a special care unit, bloodstream infection and congestive heart failure.

RESULTS: In comparison to median baseline levels of 2.30 ng/ml (interquartile range 1.66-3.67 ng/ml), levels of PTX3 were significantly elevated in patients admitted to the intensive-/medium care unit (median value 44.4 ng/ml, interquartile range 13.6-105.9 ng/ml) and in patients referred to the ward (median value 14.2 ng/ml, interquartile range 7.01-25.1 ng/ml). In addition, PTX3 was associated with duration of hospital stay and acute congestive heart failure. The levels were predictive for bloodstream infection (AUC=0.71; 95% CI 0.62-0.81).

CONCLUSIONS: PTX3 may be a useful marker for differentiation of patients with severe disease in patients presenting with fever to the emergency department.

Original language	English
Pages (from-to)	122-7
Number of pages	6
Journal	The Journal of Infection
Volume	60
Issue number	2
DOIs	https://doi.org/10.1016/j.jinf.2009.11.010
Publication status	Published - Feb 2010

Keywords

Aged
Biomarkers
C-Reactive Protein/analysis
Emergency Service, Hospital
Female
Fever of Unknown Origin/diagnosis
Humans
Male
Middle Aged
Prognosis
Serum Amyloid P-Component/analysis
Severity of Illness Index

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10.1016/j.jinf.2009.11.010

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title = "PTX3 predicts severe disease in febrile patients at the emergency department",

abstract = "OBJECTIVES: The long pentraxin PTX3 is a promising marker of disease severity in severely ill patients. In order to identify patients warranting critical care as quickly as possible, we investigated the value of PTX3 as a biomarker for disease severity in patients presenting with fever at the emergency department.METHODS: Levels of PTX3 were measured in 211 febrile patients at the emergency and the levels were linked to markers of disease severity including admittance to a special care unit, bloodstream infection and congestive heart failure.RESULTS: In comparison to median baseline levels of 2.30 ng/ml (interquartile range 1.66-3.67 ng/ml), levels of PTX3 were significantly elevated in patients admitted to the intensive-/medium care unit (median value 44.4 ng/ml, interquartile range 13.6-105.9 ng/ml) and in patients referred to the ward (median value 14.2 ng/ml, interquartile range 7.01-25.1 ng/ml). In addition, PTX3 was associated with duration of hospital stay and acute congestive heart failure. The levels were predictive for bloodstream infection (AUC=0.71; 95\% CI 0.62-0.81).CONCLUSIONS: PTX3 may be a useful marker for differentiation of patients with severe disease in patients presenting with fever to the emergency department.",

keywords = "Aged, Biomarkers, C-Reactive Protein/analysis, Emergency Service, Hospital, Female, Fever of Unknown Origin/diagnosis, Humans, Male, Middle Aged, Prognosis, Serum Amyloid P-Component/analysis, Severity of Illness Index",

author = "\{de Kruif\}, \{Martijn D\} and Maarten Limper and Karlien Sierhuis and Wagenaar, \{Jiri F P\} and Spek, \{C Arnold\} and Cecilia Garlanda and Alessia Cotena and Alberto Mantovani and \{ten Cate\}, Hugo and Reitsma, \{Pieter H\} and \{van Gorp\}, \{Eric C M\}",

year = "2010",

month = feb,

doi = "10.1016/j.jinf.2009.11.010",

language = "English",

volume = "60",

pages = "122--7",

journal = "The Journal of Infection",

issn = "0163-4453",

publisher = "W.B. Saunders Ltd",

number = "2",

}

TY - JOUR

T1 - PTX3 predicts severe disease in febrile patients at the emergency department

AU - de Kruif, Martijn D

AU - Limper, Maarten

AU - Sierhuis, Karlien

AU - Wagenaar, Jiri F P

AU - Spek, C Arnold

AU - Garlanda, Cecilia

AU - Cotena, Alessia

AU - Mantovani, Alberto

AU - ten Cate, Hugo

AU - Reitsma, Pieter H

AU - van Gorp, Eric C M

PY - 2010/2

Y1 - 2010/2

N2 - OBJECTIVES: The long pentraxin PTX3 is a promising marker of disease severity in severely ill patients. In order to identify patients warranting critical care as quickly as possible, we investigated the value of PTX3 as a biomarker for disease severity in patients presenting with fever at the emergency department.METHODS: Levels of PTX3 were measured in 211 febrile patients at the emergency and the levels were linked to markers of disease severity including admittance to a special care unit, bloodstream infection and congestive heart failure.RESULTS: In comparison to median baseline levels of 2.30 ng/ml (interquartile range 1.66-3.67 ng/ml), levels of PTX3 were significantly elevated in patients admitted to the intensive-/medium care unit (median value 44.4 ng/ml, interquartile range 13.6-105.9 ng/ml) and in patients referred to the ward (median value 14.2 ng/ml, interquartile range 7.01-25.1 ng/ml). In addition, PTX3 was associated with duration of hospital stay and acute congestive heart failure. The levels were predictive for bloodstream infection (AUC=0.71; 95% CI 0.62-0.81).CONCLUSIONS: PTX3 may be a useful marker for differentiation of patients with severe disease in patients presenting with fever to the emergency department.

AB - OBJECTIVES: The long pentraxin PTX3 is a promising marker of disease severity in severely ill patients. In order to identify patients warranting critical care as quickly as possible, we investigated the value of PTX3 as a biomarker for disease severity in patients presenting with fever at the emergency department.METHODS: Levels of PTX3 were measured in 211 febrile patients at the emergency and the levels were linked to markers of disease severity including admittance to a special care unit, bloodstream infection and congestive heart failure.RESULTS: In comparison to median baseline levels of 2.30 ng/ml (interquartile range 1.66-3.67 ng/ml), levels of PTX3 were significantly elevated in patients admitted to the intensive-/medium care unit (median value 44.4 ng/ml, interquartile range 13.6-105.9 ng/ml) and in patients referred to the ward (median value 14.2 ng/ml, interquartile range 7.01-25.1 ng/ml). In addition, PTX3 was associated with duration of hospital stay and acute congestive heart failure. The levels were predictive for bloodstream infection (AUC=0.71; 95% CI 0.62-0.81).CONCLUSIONS: PTX3 may be a useful marker for differentiation of patients with severe disease in patients presenting with fever to the emergency department.

KW - Aged

KW - Biomarkers

KW - C-Reactive Protein/analysis

KW - Emergency Service, Hospital

KW - Female

KW - Fever of Unknown Origin/diagnosis

KW - Humans

KW - Male

KW - Middle Aged

KW - Prognosis

KW - Serum Amyloid P-Component/analysis

KW - Severity of Illness Index

U2 - 10.1016/j.jinf.2009.11.010

DO - 10.1016/j.jinf.2009.11.010

M3 - Article

C2 - 19961874

SN - 0163-4453

VL - 60

SP - 122

EP - 127

JO - The Journal of Infection

JF - The Journal of Infection

IS - 2

ER -

PTX3 predicts severe disease in febrile patients at the emergency department

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Keywords

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