Psychosocial factors and cancer incidence (PSY-CA): Protocol for individual participant data meta-analyses

Lonneke A. van Tuijl; Adri C. Voogd; Alexander de Graeff; Adriaan W. Hoogendoorn; Adelita V. Ranchor; Kuan Yu Pan; Maartje Basten; Femke Lamers; Mirjam I. Geerlings; Jessica G. Abell; Philip Awadalla; Marije F. Bakker; Aartjan T.F. Beekman; Ottar Bjerkeset; Andy Boyd; Yunsong Cui; Henrike Galenkamp; Bert Garssen; Sean Hellingman; Martijn Huisman; Anke Huss; Melanie R. Keats; Almar A.L. Kok; Annemarie I. Luik; Nolwenn Noisel; N. Charlotte Onland-Moret; Yves Payette; Brenda W.J.H. Penninx; Lützen Portengen; Ina Rissanen; Annelieke M. Roest; Judith G.M. Rosmalen; Rikje Ruiter; Robert A. Schoevers; David M. Soave; Mandy Spaan; Andrew Steptoe; Karien Stronks; Erik R. Sund; Ellen Sweeney; Alison Teyhan; Ilonca Vaartjes; Kimberly D. van der Willik; Flora E. van Leeuwen; Rutger van Petersen; W. M.Monique Verschuren; Frank Visseren; Roel Vermeulen; Joost Dekker

doi:10.1002/brb3.2340

Psychosocial factors and cancer incidence (PSY-CA): Protocol for individual participant data meta-analyses

Lonneke A. van Tuijl^*, Adri C. Voogd, Alexander de Graeff, Adriaan W. Hoogendoorn, Adelita V. Ranchor, Kuan Yu Pan, Maartje Basten, Femke Lamers, Mirjam I. Geerlings, Jessica G. Abell, Philip Awadalla, Marije F. Bakker, Aartjan T.F. Beekman, Ottar Bjerkeset, Andy Boyd, Yunsong Cui, Henrike Galenkamp, Bert Garssen, Sean Hellingman, Martijn HuismanAnke Huss, Melanie R. Keats, Almar A.L. Kok, Annemarie I. Luik, Nolwenn Noisel, N. Charlotte Onland-Moret, Yves Payette, Brenda W.J.H. Penninx, Lützen Portengen, Ina Rissanen, Annelieke M. Roest, Judith G.M. Rosmalen, Rikje Ruiter, Robert A. Schoevers, David M. Soave, Mandy Spaan, Andrew Steptoe, Karien Stronks, Erik R. Sund, Ellen Sweeney, Alison Teyhan, Ilonca Vaartjes, Kimberly D. van der Willik, Flora E. van Leeuwen, Rutger van Petersen, W. M.Monique Verschuren, Frank Visseren, Roel Vermeulen, Joost Dekker

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Objectives: Psychosocial factors have been hypothesized to increase the risk of cancer. This study aims (1) to test whether psychosocial factors (depression, anxiety, recent loss events, subjective social support, relationship status, general distress, and neuroticism) are associated with the incidence of any cancer (any, breast, lung, prostate, colorectal, smoking-related, and alcohol-related); (2) to test the interaction between psychosocial factors and factors related to cancer risk (smoking, alcohol use, weight, physical activity, sedentary behavior, sleep, age, sex, education, hormone replacement therapy, and menopausal status) with regard to the incidence of cancer; and (3) to test the mediating role of health behaviors (smoking, alcohol use, weight, physical activity, sedentary behavior, and sleep) in the relationship between psychosocial factors and the incidence of cancer. Methods: The psychosocial factors and cancer incidence (PSY-CA) consortium was established involving experts in the field of (psycho-)oncology, methodology, and epidemiology. Using data collected in 18 cohorts (N = 617,355), a preplanned two-stage individual participant data (IPD) meta-analysis is proposed. Standardized analyses will be conducted on harmonized datasets for each cohort (stage 1), and meta-analyses will be performed on the risk estimates (stage 2). Conclusion: PSY-CA aims to elucidate the relationship between psychosocial factors and cancer risk by addressing several shortcomings of prior meta-analyses.

Original language	English
Article number	e2340
Pages (from-to)	1-13
Journal	Brain and Behavior
Volume	11
Issue number	10
Early online date	2 Sept 2021
DOIs	https://doi.org/10.1002/brb3.2340
Publication status	Published - Oct 2021

Keywords

Anxiety
Cohort Studies
Humans
Incidence
Male
Meta-Analysis as Topic
Neoplasms/epidemiology
Social Support

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Brain and Behavior - 2021 - Tuijl - Psychosocial factors and cancer incidence PSY‐CA Protocol for individual participantFinal published version, 374 KBLicence: CC BY

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van Tuijl, L. A., Voogd, A. C., de Graeff, A., Hoogendoorn, A. W., Ranchor, A. V., Pan, K. Y., Basten, M., Lamers, F., Geerlings, M. I., Abell, J. G., Awadalla, P., Bakker, M. F., Beekman, A. T. F., Bjerkeset, O., Boyd, A., Cui, Y., Galenkamp, H., Garssen, B., Hellingman, S., ... Dekker, J. (2021). Psychosocial factors and cancer incidence (PSY-CA): Protocol for individual participant data meta-analyses. Brain and Behavior, 11(10), 1-13. Article e2340. https://doi.org/10.1002/brb3.2340

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title = "Psychosocial factors and cancer incidence (PSY-CA): Protocol for individual participant data meta-analyses",

abstract = "Objectives: Psychosocial factors have been hypothesized to increase the risk of cancer. This study aims (1) to test whether psychosocial factors (depression, anxiety, recent loss events, subjective social support, relationship status, general distress, and neuroticism) are associated with the incidence of any cancer (any, breast, lung, prostate, colorectal, smoking-related, and alcohol-related); (2) to test the interaction between psychosocial factors and factors related to cancer risk (smoking, alcohol use, weight, physical activity, sedentary behavior, sleep, age, sex, education, hormone replacement therapy, and menopausal status) with regard to the incidence of cancer; and (3) to test the mediating role of health behaviors (smoking, alcohol use, weight, physical activity, sedentary behavior, and sleep) in the relationship between psychosocial factors and the incidence of cancer. Methods: The psychosocial factors and cancer incidence (PSY-CA) consortium was established involving experts in the field of (psycho-)oncology, methodology, and epidemiology. Using data collected in 18 cohorts (N = 617,355), a preplanned two-stage individual participant data (IPD) meta-analysis is proposed. Standardized analyses will be conducted on harmonized datasets for each cohort (stage 1), and meta-analyses will be performed on the risk estimates (stage 2). Conclusion: PSY-CA aims to elucidate the relationship between psychosocial factors and cancer risk by addressing several shortcomings of prior meta-analyses.",

keywords = "Anxiety, Cohort Studies, Humans, Incidence, Male, Meta-Analysis as Topic, Neoplasms/epidemiology, Social Support",

author = "{van Tuijl}, {Lonneke A.} and Voogd, {Adri C.} and {de Graeff}, Alexander and Hoogendoorn, {Adriaan W.} and Ranchor, {Adelita V.} and Pan, {Kuan Yu} and Maartje Basten and Femke Lamers and Geerlings, {Mirjam I.} and Abell, {Jessica G.} and Philip Awadalla and Bakker, {Marije F.} and Beekman, {Aartjan T.F.} and Ottar Bjerkeset and Andy Boyd and Yunsong Cui and Henrike Galenkamp and Bert Garssen and Sean Hellingman and Martijn Huisman and Anke Huss and Keats, {Melanie R.} and Kok, {Almar A.L.} and Luik, {Annemarie I.} and Nolwenn Noisel and Onland-Moret, {N. Charlotte} and Yves Payette and Penninx, {Brenda W.J.H.} and L{\"u}tzen Portengen and Ina Rissanen and Roest, {Annelieke M.} and Rosmalen, {Judith G.M.} and Rikje Ruiter and Schoevers, {Robert A.} and Soave, {David M.} and Mandy Spaan and Andrew Steptoe and Karien Stronks and Sund, {Erik R.} and Ellen Sweeney and Alison Teyhan and Ilonca Vaartjes and {van der Willik}, {Kimberly D.} and {van Leeuwen}, {Flora E.} and {van Petersen}, Rutger and Verschuren, {W. M.Monique} and Frank Visseren and Roel Vermeulen and Joost Dekker",

note = "Publisher Copyright: {\textcopyright} 2021 The Authors. Brain and Behavior published by Wiley Periodicals LLC",

year = "2021",

month = oct,

doi = "10.1002/brb3.2340",

language = "English",

volume = "11",

pages = "1--13",

number = "10",

}

van Tuijl, LA, Voogd, AC, de Graeff, A, Hoogendoorn, AW, Ranchor, AV, Pan, KY, Basten, M, Lamers, F, Geerlings, MI, Abell, JG, Awadalla, P, Bakker, MF, Beekman, ATF, Bjerkeset, O, Boyd, A, Cui, Y, Galenkamp, H, Garssen, B, Hellingman, S, Huisman, M, Huss, A, Keats, MR, Kok, AAL, Luik, AI, Noisel, N, Onland-Moret, NC, Payette, Y, Penninx, BWJH, Portengen, L, Rissanen, I, Roest, AM, Rosmalen, JGM, Ruiter, R, Schoevers, RA, Soave, DM, Spaan, M, Steptoe, A, Stronks, K, Sund, ER, Sweeney, E, Teyhan, A, Vaartjes, I, van der Willik, KD, van Leeuwen, FE, van Petersen, R, Verschuren, WMM , Visseren, F , Vermeulen, R & Dekker, J 2021, 'Psychosocial factors and cancer incidence (PSY-CA): Protocol for individual participant data meta-analyses', Brain and Behavior, vol. 11, no. 10, e2340, pp. 1-13. https://doi.org/10.1002/brb3.2340

TY - JOUR

T1 - Psychosocial factors and cancer incidence (PSY-CA)

T2 - Protocol for individual participant data meta-analyses

AU - van Tuijl, Lonneke A.

AU - Voogd, Adri C.

AU - de Graeff, Alexander

AU - Hoogendoorn, Adriaan W.

AU - Ranchor, Adelita V.

AU - Pan, Kuan Yu

AU - Basten, Maartje

AU - Lamers, Femke

AU - Geerlings, Mirjam I.

AU - Abell, Jessica G.

AU - Awadalla, Philip

AU - Bakker, Marije F.

AU - Beekman, Aartjan T.F.

AU - Bjerkeset, Ottar

AU - Boyd, Andy

AU - Cui, Yunsong

AU - Galenkamp, Henrike

AU - Garssen, Bert

AU - Hellingman, Sean

AU - Huisman, Martijn

AU - Huss, Anke

AU - Keats, Melanie R.

AU - Kok, Almar A.L.

AU - Luik, Annemarie I.

AU - Noisel, Nolwenn

AU - Onland-Moret, N. Charlotte

AU - Payette, Yves

AU - Penninx, Brenda W.J.H.

AU - Portengen, Lützen

AU - Rissanen, Ina

AU - Roest, Annelieke M.

AU - Rosmalen, Judith G.M.

AU - Ruiter, Rikje

AU - Schoevers, Robert A.

AU - Soave, David M.

AU - Spaan, Mandy

AU - Steptoe, Andrew

AU - Stronks, Karien

AU - Sund, Erik R.

AU - Sweeney, Ellen

AU - Teyhan, Alison

AU - Vaartjes, Ilonca

AU - van der Willik, Kimberly D.

AU - van Leeuwen, Flora E.

AU - van Petersen, Rutger

AU - Verschuren, W. M.Monique

AU - Visseren, Frank

AU - Vermeulen, Roel

AU - Dekker, Joost

PY - 2021/10

Y1 - 2021/10

N2 - Objectives: Psychosocial factors have been hypothesized to increase the risk of cancer. This study aims (1) to test whether psychosocial factors (depression, anxiety, recent loss events, subjective social support, relationship status, general distress, and neuroticism) are associated with the incidence of any cancer (any, breast, lung, prostate, colorectal, smoking-related, and alcohol-related); (2) to test the interaction between psychosocial factors and factors related to cancer risk (smoking, alcohol use, weight, physical activity, sedentary behavior, sleep, age, sex, education, hormone replacement therapy, and menopausal status) with regard to the incidence of cancer; and (3) to test the mediating role of health behaviors (smoking, alcohol use, weight, physical activity, sedentary behavior, and sleep) in the relationship between psychosocial factors and the incidence of cancer. Methods: The psychosocial factors and cancer incidence (PSY-CA) consortium was established involving experts in the field of (psycho-)oncology, methodology, and epidemiology. Using data collected in 18 cohorts (N = 617,355), a preplanned two-stage individual participant data (IPD) meta-analysis is proposed. Standardized analyses will be conducted on harmonized datasets for each cohort (stage 1), and meta-analyses will be performed on the risk estimates (stage 2). Conclusion: PSY-CA aims to elucidate the relationship between psychosocial factors and cancer risk by addressing several shortcomings of prior meta-analyses.

AB - Objectives: Psychosocial factors have been hypothesized to increase the risk of cancer. This study aims (1) to test whether psychosocial factors (depression, anxiety, recent loss events, subjective social support, relationship status, general distress, and neuroticism) are associated with the incidence of any cancer (any, breast, lung, prostate, colorectal, smoking-related, and alcohol-related); (2) to test the interaction between psychosocial factors and factors related to cancer risk (smoking, alcohol use, weight, physical activity, sedentary behavior, sleep, age, sex, education, hormone replacement therapy, and menopausal status) with regard to the incidence of cancer; and (3) to test the mediating role of health behaviors (smoking, alcohol use, weight, physical activity, sedentary behavior, and sleep) in the relationship between psychosocial factors and the incidence of cancer. Methods: The psychosocial factors and cancer incidence (PSY-CA) consortium was established involving experts in the field of (psycho-)oncology, methodology, and epidemiology. Using data collected in 18 cohorts (N = 617,355), a preplanned two-stage individual participant data (IPD) meta-analysis is proposed. Standardized analyses will be conducted on harmonized datasets for each cohort (stage 1), and meta-analyses will be performed on the risk estimates (stage 2). Conclusion: PSY-CA aims to elucidate the relationship between psychosocial factors and cancer risk by addressing several shortcomings of prior meta-analyses.

KW - Anxiety

KW - Cohort Studies

KW - Humans

KW - Incidence

KW - Male

KW - Meta-Analysis as Topic

KW - Neoplasms/epidemiology

KW - Social Support

UR - http://www.scopus.com/inward/record.url?scp=85114316211&partnerID=8YFLogxK

U2 - 10.1002/brb3.2340

DO - 10.1002/brb3.2340

M3 - Article

C2 - 34473425

SN - 2162-3279

VL - 11

SP - 1

EP - 13

JO - Brain and Behavior

JF - Brain and Behavior

IS - 10

M1 - e2340

ER -

Psychosocial factors and cancer incidence (PSY-CA): Protocol for individual participant data meta-analyses

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