Protein quality control in Alzheimer's disease by the ubiquitin proteasome system

F M S de Vrij; D F Fischer; F W van Leeuwen; E M Hol

doi:10.1016/j.pneurobio.2004.10.001

Protein quality control in Alzheimer's disease by the ubiquitin proteasome system

F M S de Vrij, D F Fischer, F W van Leeuwen, E M Hol

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The ubiquitin proteasome system (UPS) is the major protein quality control system in eukaryotic cells. Many neurodegenerative diseases are characterized by aggregates and inclusions of aberrant proteins, implying a sub-optimal functioning or defective UPS. The last few years have seen increasing evidence for the involvement of the UPS in neurodegenerative disorders, including Alzheimer's disease (AD). Notably, decreases in proteasome activity were detected in several cortical areas in AD patients. In addition, proteins that accumulate in the classical hallmarks of AD were linked to UPS function. This review specifically discusses the involvement of the UPS in AD pathogenesis. First, a detailed overview of the UPS is presented, after which AD pathology and its relation to the UPS is discussed.

Original language	English
Pages (from-to)	249-70
Number of pages	22
Journal	Progress in Neurobiology
Volume	74
Issue number	5
DOIs	https://doi.org/10.1016/j.pneurobio.2004.10.001
Publication status	Published - Dec 2004

Keywords

Aging
Alzheimer Disease
Amyloid beta-Peptides
Animals
Apolipoproteins E
Humans
Learning
Mutation
Oxidative Stress
Proteasome Endopeptidase Complex
Protein Processing, Post-Translational
Ubiquitin
tau Proteins
Journal Article
Research Support, Non-U.S. Gov't
Review

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10.1016/j.pneurobio.2004.10.001

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title = "Protein quality control in Alzheimer's disease by the ubiquitin proteasome system",

abstract = "The ubiquitin proteasome system (UPS) is the major protein quality control system in eukaryotic cells. Many neurodegenerative diseases are characterized by aggregates and inclusions of aberrant proteins, implying a sub-optimal functioning or defective UPS. The last few years have seen increasing evidence for the involvement of the UPS in neurodegenerative disorders, including Alzheimer's disease (AD). Notably, decreases in proteasome activity were detected in several cortical areas in AD patients. In addition, proteins that accumulate in the classical hallmarks of AD were linked to UPS function. This review specifically discusses the involvement of the UPS in AD pathogenesis. First, a detailed overview of the UPS is presented, after which AD pathology and its relation to the UPS is discussed.",

keywords = "Aging, Alzheimer Disease, Amyloid beta-Peptides, Animals, Apolipoproteins E, Humans, Learning, Mutation, Oxidative Stress, Proteasome Endopeptidase Complex, Protein Processing, Post-Translational, Ubiquitin, tau Proteins, Journal Article, Research Support, Non-U.S. Gov't, Review",

author = "{de Vrij}, {F M S} and Fischer, {D F} and {van Leeuwen}, {F W} and Hol, {E M}",

year = "2004",

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language = "English",

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journal = "Progress in Neurobiology",

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T1 - Protein quality control in Alzheimer's disease by the ubiquitin proteasome system

AU - de Vrij, F M S

AU - Fischer, D F

AU - van Leeuwen, F W

AU - Hol, E M

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AB - The ubiquitin proteasome system (UPS) is the major protein quality control system in eukaryotic cells. Many neurodegenerative diseases are characterized by aggregates and inclusions of aberrant proteins, implying a sub-optimal functioning or defective UPS. The last few years have seen increasing evidence for the involvement of the UPS in neurodegenerative disorders, including Alzheimer's disease (AD). Notably, decreases in proteasome activity were detected in several cortical areas in AD patients. In addition, proteins that accumulate in the classical hallmarks of AD were linked to UPS function. This review specifically discusses the involvement of the UPS in AD pathogenesis. First, a detailed overview of the UPS is presented, after which AD pathology and its relation to the UPS is discussed.

KW - Aging

KW - Alzheimer Disease

KW - Amyloid beta-Peptides

KW - Animals

KW - Apolipoproteins E

KW - Humans

KW - Learning

KW - Mutation

KW - Oxidative Stress

KW - Proteasome Endopeptidase Complex

KW - Protein Processing, Post-Translational

KW - Ubiquitin

KW - tau Proteins

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

KW - Review

U2 - 10.1016/j.pneurobio.2004.10.001

DO - 10.1016/j.pneurobio.2004.10.001

M3 - Article

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SN - 0301-0082

VL - 74

SP - 249

EP - 270

JO - Progress in Neurobiology

JF - Progress in Neurobiology

IS - 5

ER -

Protein quality control in Alzheimer's disease by the ubiquitin proteasome system

Abstract

Keywords

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