Prospects of targeting the gastrin releasing peptide receptor and somatostatin receptor 2 for nuclear imaging and therapy in metastatic breast cancer

Simone U. Dalm; Willemijne A M E Schrijver; Anieta M. Sieuwerts; Maxime P. Look; Angelique C J Ziel-Van Der Made; Vanja De Weerd; John W. Martens; Paul J. Van Diest; Marion De Jong; Carolien H M Van Deurzen

doi:10.1371/journal.pone.0170536

Prospects of targeting the gastrin releasing peptide receptor and somatostatin receptor 2 for nuclear imaging and therapy in metastatic breast cancer

Simone U. Dalm, Willemijne A M E Schrijver, Anieta M. Sieuwerts, Maxime P. Look, Angelique C J Ziel-Van Der Made, Vanja De Weerd, John W. Martens, Paul J. Van Diest, Marion De Jong, Carolien H M Van Deurzen

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Abstract

Background The gastrin releasing peptide receptor (GRPR) and the somatostatin receptor 2 (SSTR2) are overexpressed on primary breast cancer (BC), making them ideal candidates for receptor- mediated nuclear imaging and therapy. The aim of this study was to determine whether these receptors are also suitable targets for metastatic BC. Methods mRNA expression of human BC samples were studied by in vitro autoradiography and associated with radioligand binding. Next, GRPR and SSTR2 mRNA levels of 60 paired primary BCs and metastases from different sites were measured by quantitative reverse transcriptase polymerase chain reaction. Receptor mRNA expression levels were associated with clinico-pathological factors and expression levels of primary tumors and corresponding metastases were compared. Results Binding of GRPR and SSTR radioligands to tumor tissue correlated significantly with receptor mRNA expression. High GRPR and SSTR2 mRNA levels were associated with estrogen receptor (ESR1)-positive tumors (p

Original language	English
Article number	e0170536
Journal	PLoS ONE [E]
Volume	12
Issue number	1
DOIs	https://doi.org/10.1371/journal.pone.0170536
Publication status	Published - 20 Jan 2017

Keywords

Gene expression
Lymph nodes
Autoradiography
Metastatic tumors
metastasis
Cancer treatment
Messenger RNA
breast cancer

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Dalm, S. U., Schrijver, W. A. M. E., Sieuwerts, A. M., Look, M. P., Ziel-Van Der Made, A. C. J., De Weerd, V., Martens, J. W., Van Diest, P. J., De Jong, M., & Van Deurzen, C. H. M. (2017). Prospects of targeting the gastrin releasing peptide receptor and somatostatin receptor 2 for nuclear imaging and therapy in metastatic breast cancer. PLoS ONE [E], 12(1), Article e0170536. https://doi.org/10.1371/journal.pone.0170536

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title = "Prospects of targeting the gastrin releasing peptide receptor and somatostatin receptor 2 for nuclear imaging and therapy in metastatic breast cancer",

abstract = "Background The gastrin releasing peptide receptor (GRPR) and the somatostatin receptor 2 (SSTR2) are overexpressed on primary breast cancer (BC), making them ideal candidates for receptor- mediated nuclear imaging and therapy. The aim of this study was to determine whether these receptors are also suitable targets for metastatic BC. Methods mRNA expression of human BC samples were studied by in vitro autoradiography and associated with radioligand binding. Next, GRPR and SSTR2 mRNA levels of 60 paired primary BCs and metastases from different sites were measured by quantitative reverse transcriptase polymerase chain reaction. Receptor mRNA expression levels were associated with clinico-pathological factors and expression levels of primary tumors and corresponding metastases were compared. Results Binding of GRPR and SSTR radioligands to tumor tissue correlated significantly with receptor mRNA expression. High GRPR and SSTR2 mRNA levels were associated with estrogen receptor (ESR1)-positive tumors (p",

keywords = "Gene expression, Lymph nodes, Autoradiography, Metastatic tumors, metastasis, Cancer treatment, Messenger RNA, breast cancer",

author = "Dalm, {Simone U.} and Schrijver, {Willemijne A M E} and Sieuwerts, {Anieta M.} and Look, {Maxime P.} and {Ziel-Van Der Made}, {Angelique C J} and {De Weerd}, Vanja and Martens, {John W.} and {Van Diest}, {Paul J.} and {De Jong}, Marion and {Van Deurzen}, {Carolien H M}",

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Dalm, SU, Schrijver, WAME, Sieuwerts, AM, Look, MP, Ziel-Van Der Made, ACJ, De Weerd, V, Martens, JW, Van Diest, PJ, De Jong, M & Van Deurzen, CHM 2017, 'Prospects of targeting the gastrin releasing peptide receptor and somatostatin receptor 2 for nuclear imaging and therapy in metastatic breast cancer', PLoS ONE [E], vol. 12, no. 1, e0170536. https://doi.org/10.1371/journal.pone.0170536

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AU - Dalm, Simone U.

AU - Schrijver, Willemijne A M E

AU - Sieuwerts, Anieta M.

AU - Look, Maxime P.

AU - Ziel-Van Der Made, Angelique C J

AU - De Weerd, Vanja

AU - Martens, John W.

AU - Van Diest, Paul J.

AU - De Jong, Marion

AU - Van Deurzen, Carolien H M

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N2 - Background The gastrin releasing peptide receptor (GRPR) and the somatostatin receptor 2 (SSTR2) are overexpressed on primary breast cancer (BC), making them ideal candidates for receptor- mediated nuclear imaging and therapy. The aim of this study was to determine whether these receptors are also suitable targets for metastatic BC. Methods mRNA expression of human BC samples were studied by in vitro autoradiography and associated with radioligand binding. Next, GRPR and SSTR2 mRNA levels of 60 paired primary BCs and metastases from different sites were measured by quantitative reverse transcriptase polymerase chain reaction. Receptor mRNA expression levels were associated with clinico-pathological factors and expression levels of primary tumors and corresponding metastases were compared. Results Binding of GRPR and SSTR radioligands to tumor tissue correlated significantly with receptor mRNA expression. High GRPR and SSTR2 mRNA levels were associated with estrogen receptor (ESR1)-positive tumors (p

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Prospects of targeting the gastrin releasing peptide receptor and somatostatin receptor 2 for nuclear imaging and therapy in metastatic breast cancer

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