Prospective Evaluation of Severe Skin Toxicity and Pain During Postmastectomy Radiation Therapy

Jean-Philippe Pignol; [Unknown] Thi Trinh Thuc Vu; Gunita Mitera; Sandy Bosnic; Helena M. Verkooijen; Pauline Truong

doi:10.1016/j.ijrobp.2014.09.022

Prospective Evaluation of Severe Skin Toxicity and Pain During Postmastectomy Radiation Therapy

Jean-Philippe Pignol^*, [Unknown] Thi Trinh Thuc Vu, Gunita Mitera, Sandy Bosnic, Helena M. Verkooijen, Pauline Truong

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Purpose: To prospectively capture acute toxicities and pain associated with postmastectomy radiation therapy (PMRT), to analyze patient and treatment risk factors for severe side effects.

Methods and Materials: Women referred for PMRT were prospectively enrolled and assessed weekly during and after radiation therapy. The endpoint included severe National Cancer Institute Common Terminology Criteria for Adverse Effects grade 3 moist desquamation, other skin symptoms, and pain.

Results: Of 257 patients, 73 (28.4%) experienced extensive moist desquamation, 84 (32.7%) Common Terminology Criteria for Adverse Effects skin toxicity grade 3, and 57 (22.2%) a pain impacting on daily life activities. Among symptoms only grade 3 moist desquamation was significantly associated with severe pain (P

Conclusions: The present cohort study suggests excessive radiation toxicity after PMRT. Among factors associated with an increase of toxicity are smoking habits and the use of skin bolus. (C) 2015 Elsevier Inc.

Original language	English
Pages (from-to)	157-164
Number of pages	8
Journal	International Journal of Radiation Oncology Biology Physics
Volume	91
Issue number	1
DOIs	https://doi.org/10.1016/j.ijrobp.2014.09.022
Publication status	Published - 1 Jan 2015

Keywords

EARLY BREAST-CANCER
LOCOREGIONAL RECURRENCE RISK
20-YEAR FOLLOW-UP
ADJUVANT RADIOTHERAPY
RANDOMIZED-TRIAL
POSTOPERATIVE RADIOTHERAPY
PREMENOPAUSAL WOMEN
MASTECTOMY
COMPLICATIONS
RECONSTRUCTION

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10.1016/j.ijrobp.2014.09.022

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title = "Prospective Evaluation of Severe Skin Toxicity and Pain During Postmastectomy Radiation Therapy",

abstract = "Purpose: To prospectively capture acute toxicities and pain associated with postmastectomy radiation therapy (PMRT), to analyze patient and treatment risk factors for severe side effects.Methods and Materials: Women referred for PMRT were prospectively enrolled and assessed weekly during and after radiation therapy. The endpoint included severe National Cancer Institute Common Terminology Criteria for Adverse Effects grade 3 moist desquamation, other skin symptoms, and pain.Results: Of 257 patients, 73 (28.4%) experienced extensive moist desquamation, 84 (32.7%) Common Terminology Criteria for Adverse Effects skin toxicity grade 3, and 57 (22.2%) a pain impacting on daily life activities. Among symptoms only grade 3 moist desquamation was significantly associated with severe pain (PConclusions: The present cohort study suggests excessive radiation toxicity after PMRT. Among factors associated with an increase of toxicity are smoking habits and the use of skin bolus. (C) 2015 Elsevier Inc.",

keywords = "EARLY BREAST-CANCER, LOCOREGIONAL RECURRENCE RISK, 20-YEAR FOLLOW-UP, ADJUVANT RADIOTHERAPY, RANDOMIZED-TRIAL, POSTOPERATIVE RADIOTHERAPY, PREMENOPAUSAL WOMEN, MASTECTOMY, COMPLICATIONS, RECONSTRUCTION",

author = "Jean-Philippe Pignol and {Thi Trinh Thuc Vu}, [Unknown] and Gunita Mitera and Sandy Bosnic and Verkooijen, {Helena M.} and Pauline Truong",

year = "2015",

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doi = "10.1016/j.ijrobp.2014.09.022",

language = "English",

volume = "91",

pages = "157--164",

journal = "International Journal of Radiation Oncology Biology Physics",

issn = "0360-3016",

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T1 - Prospective Evaluation of Severe Skin Toxicity and Pain During Postmastectomy Radiation Therapy

AU - Pignol, Jean-Philippe

AU - Thi Trinh Thuc Vu, [Unknown]

AU - Mitera, Gunita

AU - Bosnic, Sandy

AU - Verkooijen, Helena M.

AU - Truong, Pauline

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Purpose: To prospectively capture acute toxicities and pain associated with postmastectomy radiation therapy (PMRT), to analyze patient and treatment risk factors for severe side effects.Methods and Materials: Women referred for PMRT were prospectively enrolled and assessed weekly during and after radiation therapy. The endpoint included severe National Cancer Institute Common Terminology Criteria for Adverse Effects grade 3 moist desquamation, other skin symptoms, and pain.Results: Of 257 patients, 73 (28.4%) experienced extensive moist desquamation, 84 (32.7%) Common Terminology Criteria for Adverse Effects skin toxicity grade 3, and 57 (22.2%) a pain impacting on daily life activities. Among symptoms only grade 3 moist desquamation was significantly associated with severe pain (PConclusions: The present cohort study suggests excessive radiation toxicity after PMRT. Among factors associated with an increase of toxicity are smoking habits and the use of skin bolus. (C) 2015 Elsevier Inc.

AB - Purpose: To prospectively capture acute toxicities and pain associated with postmastectomy radiation therapy (PMRT), to analyze patient and treatment risk factors for severe side effects.Methods and Materials: Women referred for PMRT were prospectively enrolled and assessed weekly during and after radiation therapy. The endpoint included severe National Cancer Institute Common Terminology Criteria for Adverse Effects grade 3 moist desquamation, other skin symptoms, and pain.Results: Of 257 patients, 73 (28.4%) experienced extensive moist desquamation, 84 (32.7%) Common Terminology Criteria for Adverse Effects skin toxicity grade 3, and 57 (22.2%) a pain impacting on daily life activities. Among symptoms only grade 3 moist desquamation was significantly associated with severe pain (PConclusions: The present cohort study suggests excessive radiation toxicity after PMRT. Among factors associated with an increase of toxicity are smoking habits and the use of skin bolus. (C) 2015 Elsevier Inc.

KW - EARLY BREAST-CANCER

KW - LOCOREGIONAL RECURRENCE RISK

KW - 20-YEAR FOLLOW-UP

KW - ADJUVANT RADIOTHERAPY

KW - RANDOMIZED-TRIAL

KW - POSTOPERATIVE RADIOTHERAPY

KW - PREMENOPAUSAL WOMEN

KW - MASTECTOMY

KW - COMPLICATIONS

KW - RECONSTRUCTION

U2 - 10.1016/j.ijrobp.2014.09.022

DO - 10.1016/j.ijrobp.2014.09.022

M3 - Article

SN - 0360-3016

VL - 91

SP - 157

EP - 164

JO - International Journal of Radiation Oncology Biology Physics

JF - International Journal of Radiation Oncology Biology Physics

IS - 1

ER -

Prospective Evaluation of Severe Skin Toxicity and Pain During Postmastectomy Radiation Therapy

Abstract

Keywords

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