TY - JOUR
T1 - Prolonged Cone b-Wave on Electroretinography Is Associated with Severity of Inflammation in Noninfectious Uveitis
AU - Brouwer, Anna H.
AU - de Wit, Gerard C.
AU - ten Dam, Ninette H.
AU - Wijnhoven, Ralph
AU - van Genderen, Maria M.
AU - de Boer, Joke H.
N1 - Funding Information:
All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest and none were reported. Funding/Support: Supported by Dr. F.P. Fischer Stichting and Vereniging Bartiméus Sonneheerdt , who contributed through unrestricted grants from UitZicht, the Netherlands. The funding organizations had no role in the design or conduct of this research. Financial Disclosures: Dr. de Wit is an employee of Bartiméus; and is a sole proprietor of Optical Diagnostics ( http://www.opticaldiagnostics.com ). Dr. de Boer is a compensated speaker for Abbvie. Drs. Brouwer, ten Dam, and Wijnhoven have no financial disclosures.
Funding Information:
All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest and none were reported. Funding/Support: Supported by Dr. F.P. Fischer Stichting and Vereniging Bartim?us Sonneheerdt, who contributed through unrestricted grants from UitZicht, the Netherlands. The funding organizations had no role in the design or conduct of this research. Financial Disclosures: Dr. de Wit is an employee of Bartim?us; and is a sole proprietor of Optical Diagnostics (http://www.opticaldiagnostics.com). Dr. de Boer is a compensated speaker for Abbvie. Drs. Brouwer, ten Dam, and Wijnhoven have no financial disclosures. The authors thank all patients for participating in the study. The authors also thank J. Ossewaarde-van Norel and L. Ho (University Medical Centre Utrecht) for help with recruiting patients; D. G?ltzau, Y. Burgers, and M. Ballast (University Medical Centre Utrecht) for help with recording the ERGs; F. Riemslag and H. Talsma (Bartim?us Diagnostic Centre for complex visual disorders, Zeist) for giving additional electrophysiological advice; and S. Risseeuw (University Medical Centre Utrecht) for advice with statistical analysis.
Publisher Copyright:
© 2019 Elsevier Inc.
PY - 2019/11
Y1 - 2019/11
N2 - Purpose: This study sought to investigate retinal function in patients with noninfectious uveitis by using full-field electroretinography (ERG) and correlate the ERG to disease duration and severity of inflammation. Design: Prospective cohort study. Methods: Patients (n = 200) with noninfectious uveitis and a disease duration of <1 year (group A [n = 80]) and those with a disease duration of >5 years (group B [n = 120]) were included. ERGs of the total 355 uveitis eyes were measured according to an extended International Society for Clinical Electrophysiology of Vision protocol. ERG abnormalities were related to demographics and uveitis characteristics, including anatomical classification, duration of uveitis, severity of inflammation, best corrected visual acuity (BCVA), cystoid macular edema (CME), and the highest fluorescein angiography (FA) score during the course of the disease. Results: ERGs showed abnormalities in 235 eyes (66.2%). The most frequent and pronounced ERG abnormality was a prolonged implicit time of the cone b-wave (151 eyes [42.5%]), which was associated with vitritis (P =.005); cells in the anterior chamber (P =.007); the highest fluorescein angiography score (P =.011); age (P < 0.001); and pupil diameter (P < 0.001). BCVA was relatively good (0.05 logMAR [interquartile range {IQR}, 0.011, 0.22]) and not associated with this ERG abnormality. There were no differences between the ERG abnormalities in group A and those in group B and no significant associations between ERG abnormalities and anatomical classification or specific diagnoses. Conclusions: ERG results are frequently affected in cases of noninfectious uveitis of all anatomic subtypes, including anterior uveitis without apparent inflammation of the posterior segment. ERG abnormalities appear to be associated with the severity of inflammation from both the present and the past and therefore may be seen even when signs of retinal inflammation have disappeared.
AB - Purpose: This study sought to investigate retinal function in patients with noninfectious uveitis by using full-field electroretinography (ERG) and correlate the ERG to disease duration and severity of inflammation. Design: Prospective cohort study. Methods: Patients (n = 200) with noninfectious uveitis and a disease duration of <1 year (group A [n = 80]) and those with a disease duration of >5 years (group B [n = 120]) were included. ERGs of the total 355 uveitis eyes were measured according to an extended International Society for Clinical Electrophysiology of Vision protocol. ERG abnormalities were related to demographics and uveitis characteristics, including anatomical classification, duration of uveitis, severity of inflammation, best corrected visual acuity (BCVA), cystoid macular edema (CME), and the highest fluorescein angiography (FA) score during the course of the disease. Results: ERGs showed abnormalities in 235 eyes (66.2%). The most frequent and pronounced ERG abnormality was a prolonged implicit time of the cone b-wave (151 eyes [42.5%]), which was associated with vitritis (P =.005); cells in the anterior chamber (P =.007); the highest fluorescein angiography score (P =.011); age (P < 0.001); and pupil diameter (P < 0.001). BCVA was relatively good (0.05 logMAR [interquartile range {IQR}, 0.011, 0.22]) and not associated with this ERG abnormality. There were no differences between the ERG abnormalities in group A and those in group B and no significant associations between ERG abnormalities and anatomical classification or specific diagnoses. Conclusions: ERG results are frequently affected in cases of noninfectious uveitis of all anatomic subtypes, including anterior uveitis without apparent inflammation of the posterior segment. ERG abnormalities appear to be associated with the severity of inflammation from both the present and the past and therefore may be seen even when signs of retinal inflammation have disappeared.
UR - https://www.scopus.com/pages/publications/85069716594
U2 - 10.1016/j.ajo.2019.05.028
DO - 10.1016/j.ajo.2019.05.028
M3 - Article
C2 - 31173740
AN - SCOPUS:85069716594
SN - 0002-9394
VL - 207
SP - 121
EP - 129
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
ER -