Programmed death of T cells in HIV-1 infection

Linde Meyaard; Sigrid A. Otto; Richard R. Jonker; M. Janneke Mijnster; René P.M. Keet; Frank Miedema

doi:10.1126/science.1352911

Programmed death of T cells in HIV-1 infection

Linde Meyaard, Sigrid A. Otto, Richard R. Jonker, M. Janneke Mijnster, René P.M. Keet, Frank Miedema^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

808 Citations (Scopus)

Abstract

In human immunodeficiency virus (HIV) infection, functional defects and deletion of antigen-reactive T cells are more frequent than can be explained by direct viral infection. On culturing, both CD4⁺ and CD8⁺ T cells from asymptomatic HIV-infected individuals died as a result of programmed cell death (apoptosis). Apoptosis was enhanced by activation with CD3 antibodies. Programmed cell death, associated with impaired T cell reactivity, may thus be responsible for the deletion of reactive T cells that contributes to HIV-induced immunodeficiency.

Original language	English
Pages (from-to)	217-219
Number of pages	3
Journal	Science
Volume	257
Issue number	5067
DOIs	https://doi.org/10.1126/science.1352911
Publication status	Published - 1 Jan 1992

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title = "Programmed death of T cells in HIV-1 infection",

abstract = "In human immunodeficiency virus (HIV) infection, functional defects and deletion of antigen-reactive T cells are more frequent than can be explained by direct viral infection. On culturing, both CD4+ and CD8+ T cells from asymptomatic HIV-infected individuals died as a result of programmed cell death (apoptosis). Apoptosis was enhanced by activation with CD3 antibodies. Programmed cell death, associated with impaired T cell reactivity, may thus be responsible for the deletion of reactive T cells that contributes to HIV-induced immunodeficiency.",

author = "Linde Meyaard and Otto, {Sigrid A.} and Jonker, {Richard R.} and Mijnster, {M. Janneke} and Keet, {Ren{\'e} P.M.} and Frank Miedema",

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AU - Meyaard, Linde

AU - Otto, Sigrid A.

AU - Jonker, Richard R.

AU - Mijnster, M. Janneke

AU - Keet, René P.M.

AU - Miedema, Frank

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N2 - In human immunodeficiency virus (HIV) infection, functional defects and deletion of antigen-reactive T cells are more frequent than can be explained by direct viral infection. On culturing, both CD4+ and CD8+ T cells from asymptomatic HIV-infected individuals died as a result of programmed cell death (apoptosis). Apoptosis was enhanced by activation with CD3 antibodies. Programmed cell death, associated with impaired T cell reactivity, may thus be responsible for the deletion of reactive T cells that contributes to HIV-induced immunodeficiency.

AB - In human immunodeficiency virus (HIV) infection, functional defects and deletion of antigen-reactive T cells are more frequent than can be explained by direct viral infection. On culturing, both CD4+ and CD8+ T cells from asymptomatic HIV-infected individuals died as a result of programmed cell death (apoptosis). Apoptosis was enhanced by activation with CD3 antibodies. Programmed cell death, associated with impaired T cell reactivity, may thus be responsible for the deletion of reactive T cells that contributes to HIV-induced immunodeficiency.

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Programmed death of T cells in HIV-1 infection

Abstract

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