Prognostic value of lymph node ratio in head and neck squamous cell carcinoma

Yoav P Talmi; Robert P Takes; Eran E Alon; Iain J Nixon; Fernando López; Remco de Bree; Juan P Rodrigo; Ashok R Shaha; Gyorgy B Halmos; Alessandra Rinaldo; Alfio Ferlito

doi:10.1002/hed.25080

Prognostic value of lymph node ratio in head and neck squamous cell carcinoma

Yoav P Talmi
, Robert P Takes^*
, Eran E Alon
, Iain J Nixon
, Fernando López
, Remco de Bree
, Juan P Rodrigo
, Ashok R Shaha
, Gyorgy B Halmos
, Alessandra Rinaldo
, Alfio Ferlito

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

BACKGROUND: Lymph node ratio (LNR) is increasingly reported as a potential prognostic tool. The purpose of this review was to analyze the available literature on the prognostic significance of LNR in head and neck squamous cell carcinoma (HNSCC).

METHODS: A PubMed internet search was performed and articles meeting selection criteria were reviewed.

RESULTS: Twenty-eight studies were identified in the literature dealing with the prognostic value of LNR. The published results are variable with a range of cutoff values of LNR associated with prognosis (overall survival [OS] and/or disease-specific survival [DSS]) between 0.02 and 0.20, with an average of 0.09.

CONCLUSION: The LNR is reported to be of value in assessing prognosis in the patients with HNSCC. Although it is easy to calculate and could be considered in the staging of these patients, the currently available evidence in the literature does not yet provide a solid base for implementation.

Original language	English
Pages (from-to)	1082-1090
Number of pages	9
Journal	Head & neck
Volume	40
Issue number	5
Early online date	2 Feb 2018
DOIs	https://doi.org/10.1002/hed.25080
Publication status	Published - May 2018

Keywords

Journal Article
lymph node ratio
neck dissection
prognosis
head and neck squamous cell carcinoma
lymph node metastasis
Lymph Node Excision
Head and Neck Neoplasms/mortality
Prognosis
Humans
Squamous Cell Carcinoma of Head and Neck/mortality
Lymphatic Metastasis
Neoplasm Staging

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10.1002/hed.25080

Head Neck - 2018 - Talmi - Prognostic value of lymph node ratio in head and neck squamous cell carcinomaFinal published version, 662 KBLicence: Taverne

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@article{0e3754f2b97445c9a2250ebbeb141c26,

title = "Prognostic value of lymph node ratio in head and neck squamous cell carcinoma",

abstract = "BACKGROUND: Lymph node ratio (LNR) is increasingly reported as a potential prognostic tool. The purpose of this review was to analyze the available literature on the prognostic significance of LNR in head and neck squamous cell carcinoma (HNSCC).METHODS: A PubMed internet search was performed and articles meeting selection criteria were reviewed.RESULTS: Twenty-eight studies were identified in the literature dealing with the prognostic value of LNR. The published results are variable with a range of cutoff values of LNR associated with prognosis (overall survival [OS] and/or disease-specific survival [DSS]) between 0.02 and 0.20, with an average of 0.09.CONCLUSION: The LNR is reported to be of value in assessing prognosis in the patients with HNSCC. Although it is easy to calculate and could be considered in the staging of these patients, the currently available evidence in the literature does not yet provide a solid base for implementation.",

keywords = "Journal Article, lymph node ratio, neck dissection, prognosis, head and neck squamous cell carcinoma, lymph node metastasis, Lymph Node Excision, Head and Neck Neoplasms/mortality, Prognosis, Humans, Squamous Cell Carcinoma of Head and Neck/mortality, Lymphatic Metastasis, Neoplasm Staging",

author = "Talmi, \{Yoav P\} and Takes, \{Robert P\} and Alon, \{Eran E\} and Nixon, \{Iain J\} and Fernando L{\'o}pez and \{de Bree\}, Remco and Rodrigo, \{Juan P\} and Shaha, \{Ashok R\} and Halmos, \{Gyorgy B\} and Alessandra Rinaldo and Alfio Ferlito",

note = "{\textcopyright} 2018 Wiley Periodicals, Inc.",

year = "2018",

month = may,

doi = "10.1002/hed.25080",

language = "English",

volume = "40",

pages = "1082--1090",

journal = "Head \& neck",

issn = "1043-3074",

publisher = "John Wiley \& Sons Inc.",

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}

TY - JOUR

T1 - Prognostic value of lymph node ratio in head and neck squamous cell carcinoma

AU - Talmi, Yoav P

AU - Takes, Robert P

AU - Alon, Eran E

AU - Nixon, Iain J

AU - López, Fernando

AU - de Bree, Remco

AU - Rodrigo, Juan P

AU - Shaha, Ashok R

AU - Halmos, Gyorgy B

AU - Rinaldo, Alessandra

AU - Ferlito, Alfio

PY - 2018/5

Y1 - 2018/5

N2 - BACKGROUND: Lymph node ratio (LNR) is increasingly reported as a potential prognostic tool. The purpose of this review was to analyze the available literature on the prognostic significance of LNR in head and neck squamous cell carcinoma (HNSCC).METHODS: A PubMed internet search was performed and articles meeting selection criteria were reviewed.RESULTS: Twenty-eight studies were identified in the literature dealing with the prognostic value of LNR. The published results are variable with a range of cutoff values of LNR associated with prognosis (overall survival [OS] and/or disease-specific survival [DSS]) between 0.02 and 0.20, with an average of 0.09.CONCLUSION: The LNR is reported to be of value in assessing prognosis in the patients with HNSCC. Although it is easy to calculate and could be considered in the staging of these patients, the currently available evidence in the literature does not yet provide a solid base for implementation.

AB - BACKGROUND: Lymph node ratio (LNR) is increasingly reported as a potential prognostic tool. The purpose of this review was to analyze the available literature on the prognostic significance of LNR in head and neck squamous cell carcinoma (HNSCC).METHODS: A PubMed internet search was performed and articles meeting selection criteria were reviewed.RESULTS: Twenty-eight studies were identified in the literature dealing with the prognostic value of LNR. The published results are variable with a range of cutoff values of LNR associated with prognosis (overall survival [OS] and/or disease-specific survival [DSS]) between 0.02 and 0.20, with an average of 0.09.CONCLUSION: The LNR is reported to be of value in assessing prognosis in the patients with HNSCC. Although it is easy to calculate and could be considered in the staging of these patients, the currently available evidence in the literature does not yet provide a solid base for implementation.

KW - Journal Article

KW - lymph node ratio

KW - neck dissection

KW - prognosis

KW - head and neck squamous cell carcinoma

KW - lymph node metastasis

KW - Lymph Node Excision

KW - Head and Neck Neoplasms/mortality

KW - Prognosis

KW - Humans

KW - Squamous Cell Carcinoma of Head and Neck/mortality

KW - Lymphatic Metastasis

KW - Neoplasm Staging

UR - https://www.scopus.com/pages/publications/85041325693

U2 - 10.1002/hed.25080

DO - 10.1002/hed.25080

M3 - Review article

C2 - 29394461

SN - 1043-3074

VL - 40

SP - 1082

EP - 1090

JO - Head & neck

JF - Head & neck

IS - 5

ER -

Prognostic value of lymph node ratio in head and neck squamous cell carcinoma

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