Prognostic significance of visit-to-visit systolic blood pressure variability: a meta-analysis of 77,299 patients

Chenhui Tai; Yuxi Sun; Neng Dai; Dachun Xu; Wei Chen; Jiguang Wang; Athanase Protogerou; Thomas T van Sloten; Jacques Blacher; Michel E Safar; Yi Zhang; Yawei Xu

doi:10.1111/jch.12484

Prognostic significance of visit-to-visit systolic blood pressure variability: a meta-analysis of 77,299 patients

Chenhui Tai, Yuxi Sun, Neng Dai, Dachun Xu, Wei Chen, Jiguang Wang, Athanase Protogerou, Thomas T van Sloten, Jacques Blacher, Michel E Safar, Yi Zhang, Yawei Xu

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

In recent clinical investigations, visit-to-visit systolic blood pressure (SBP) variability was proven as a predictor of cardiovascular events and all-cause mortality. However, inconsistent results exist in this association. A meta-analysis of 13 prospective studies was conducted to evaluate the prognostic value of visit-to-visit SBP variability by different parameters in 77,299 patients with a mean follow-up of 6.3 years. The pooled age- and mean SBP-adjusted hazard ratios (HRs) for all-cause mortality were 1.03 (95% confidence interval [CI], 1.02-1.04; P<.001) per 1-mm Hg increase in SBP standard deviation (SD) and 1.04 (1.02-1.06, P<.001) per 1% in SBP coefficient of variation, and the corresponding values of cardiovascular mortality were 1.10 (1.02-1.17, P<.001) and 1.01 (0.99-1.03, P=.32), respectively. Moreover, a 1-mm Hg increase in SD was significantly associated with stroke, with an HR of 1.02 (1.01-1.03, P<.001). Visit-to-visit SBP variability, independent of age and mean SBP, is a predictor of cardiovascular and all-cause mortality and stroke.

Original language	English
Pages (from-to)	107-15
Number of pages	9
Journal	Journal of Clinical Hypertension
Volume	17
Issue number	2
DOIs	https://doi.org/10.1111/jch.12484
Publication status	Published - Feb 2015
Externally published	Yes

Keywords

Adult
Aged
Aged, 80 and over
Blood Pressure/physiology
Cardiovascular Diseases/epidemiology
Female
Follow-Up Studies
Humans
Hypertension/complications
Longitudinal Studies
Male
Middle Aged
Office Visits
Predictive Value of Tests
Prognosis
Prospective Studies
Risk Factors
Sensitivity and Specificity
Systole/physiology

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10.1111/jch.12484

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title = "Prognostic significance of visit-to-visit systolic blood pressure variability: a meta-analysis of 77,299 patients",

abstract = "In recent clinical investigations, visit-to-visit systolic blood pressure (SBP) variability was proven as a predictor of cardiovascular events and all-cause mortality. However, inconsistent results exist in this association. A meta-analysis of 13 prospective studies was conducted to evaluate the prognostic value of visit-to-visit SBP variability by different parameters in 77,299 patients with a mean follow-up of 6.3 years. The pooled age- and mean SBP-adjusted hazard ratios (HRs) for all-cause mortality were 1.03 (95\% confidence interval [CI], 1.02-1.04; P<.001) per 1-mm Hg increase in SBP standard deviation (SD) and 1.04 (1.02-1.06, P<.001) per 1\% in SBP coefficient of variation, and the corresponding values of cardiovascular mortality were 1.10 (1.02-1.17, P<.001) and 1.01 (0.99-1.03, P=.32), respectively. Moreover, a 1-mm Hg increase in SD was significantly associated with stroke, with an HR of 1.02 (1.01-1.03, P<.001). Visit-to-visit SBP variability, independent of age and mean SBP, is a predictor of cardiovascular and all-cause mortality and stroke.",

keywords = "Adult, Aged, Aged, 80 and over, Blood Pressure/physiology, Cardiovascular Diseases/epidemiology, Female, Follow-Up Studies, Humans, Hypertension/complications, Longitudinal Studies, Male, Middle Aged, Office Visits, Predictive Value of Tests, Prognosis, Prospective Studies, Risk Factors, Sensitivity and Specificity, Systole/physiology",

author = "Chenhui Tai and Yuxi Sun and Neng Dai and Dachun Xu and Wei Chen and Jiguang Wang and Athanase Protogerou and \{van Sloten\}, \{Thomas T\} and Jacques Blacher and Safar, \{Michel E\} and Yi Zhang and Yawei Xu",

note = "{\textcopyright} 2015 Wiley Periodicals, Inc.",

year = "2015",

month = feb,

doi = "10.1111/jch.12484",

language = "English",

volume = "17",

pages = "107--15",

journal = "Journal of Clinical Hypertension",

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TY - JOUR

T1 - Prognostic significance of visit-to-visit systolic blood pressure variability

T2 - a meta-analysis of 77,299 patients

AU - Tai, Chenhui

AU - Sun, Yuxi

AU - Dai, Neng

AU - Xu, Dachun

AU - Chen, Wei

AU - Wang, Jiguang

AU - Protogerou, Athanase

AU - van Sloten, Thomas T

AU - Blacher, Jacques

AU - Safar, Michel E

AU - Zhang, Yi

AU - Xu, Yawei

PY - 2015/2

Y1 - 2015/2

N2 - In recent clinical investigations, visit-to-visit systolic blood pressure (SBP) variability was proven as a predictor of cardiovascular events and all-cause mortality. However, inconsistent results exist in this association. A meta-analysis of 13 prospective studies was conducted to evaluate the prognostic value of visit-to-visit SBP variability by different parameters in 77,299 patients with a mean follow-up of 6.3 years. The pooled age- and mean SBP-adjusted hazard ratios (HRs) for all-cause mortality were 1.03 (95% confidence interval [CI], 1.02-1.04; P<.001) per 1-mm Hg increase in SBP standard deviation (SD) and 1.04 (1.02-1.06, P<.001) per 1% in SBP coefficient of variation, and the corresponding values of cardiovascular mortality were 1.10 (1.02-1.17, P<.001) and 1.01 (0.99-1.03, P=.32), respectively. Moreover, a 1-mm Hg increase in SD was significantly associated with stroke, with an HR of 1.02 (1.01-1.03, P<.001). Visit-to-visit SBP variability, independent of age and mean SBP, is a predictor of cardiovascular and all-cause mortality and stroke.

AB - In recent clinical investigations, visit-to-visit systolic blood pressure (SBP) variability was proven as a predictor of cardiovascular events and all-cause mortality. However, inconsistent results exist in this association. A meta-analysis of 13 prospective studies was conducted to evaluate the prognostic value of visit-to-visit SBP variability by different parameters in 77,299 patients with a mean follow-up of 6.3 years. The pooled age- and mean SBP-adjusted hazard ratios (HRs) for all-cause mortality were 1.03 (95% confidence interval [CI], 1.02-1.04; P<.001) per 1-mm Hg increase in SBP standard deviation (SD) and 1.04 (1.02-1.06, P<.001) per 1% in SBP coefficient of variation, and the corresponding values of cardiovascular mortality were 1.10 (1.02-1.17, P<.001) and 1.01 (0.99-1.03, P=.32), respectively. Moreover, a 1-mm Hg increase in SD was significantly associated with stroke, with an HR of 1.02 (1.01-1.03, P<.001). Visit-to-visit SBP variability, independent of age and mean SBP, is a predictor of cardiovascular and all-cause mortality and stroke.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Blood Pressure/physiology

KW - Cardiovascular Diseases/epidemiology

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Hypertension/complications

KW - Longitudinal Studies

KW - Male

KW - Middle Aged

KW - Office Visits

KW - Predictive Value of Tests

KW - Prognosis

KW - Prospective Studies

KW - Risk Factors

KW - Sensitivity and Specificity

KW - Systole/physiology

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DO - 10.1111/jch.12484

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SN - 1524-6175

VL - 17

SP - 107

EP - 115

JO - Journal of Clinical Hypertension

JF - Journal of Clinical Hypertension

IS - 2

ER -

Prognostic significance of visit-to-visit systolic blood pressure variability: a meta-analysis of 77,299 patients

Abstract

Keywords

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