Prognostic role of intraparotid lymph node metastasis in primary parotid cancer: Systematic review

Orlando Guntinas-Lichius; Jovanna Thielker; K Thomas Robbins; Kerry D Olsen; Ashok R Shaha; Antti A Mäkitie; Remco de Bree; Vincent Vander Poorten; Miquel Quer; Alessandra Rinaldo; Luiz Paulo Kowalski; Juan Pablo Rodrigo; Marc Hamoir; Alfio Ferlito

doi:10.1002/hed.26541

Prognostic role of intraparotid lymph node metastasis in primary parotid cancer: Systematic review

Orlando Guntinas-Lichius, Jovanna Thielker, K Thomas Robbins, Kerry D Olsen, Ashok R Shaha, Antti A Mäkitie, Remco de Bree, Vincent Vander Poorten, Miquel Quer, Alessandra Rinaldo, Luiz Paulo Kowalski, Juan Pablo Rodrigo, Marc Hamoir, Alfio Ferlito

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Abstract

BACKGROUND: The prognostic importance of intraparotid lymph node metastasis (P+) in patients with primary parotid gland carcinoma is unclear.

METHODS: Nineteen retrospective and noncomparative cohort studies, published between 1992 and 2020, met the inclusion criteria and included 2202 patients for this systematic review.

RESULTS: The pooled prevalence of the P in adult patients in the unselected studies was 24.10% (95% confidence interval = 17.95-30.25). The number of P+ lymph nodes per patient was counted in only three studies and ranged from 1 to 11. The 5-year recurrence-free survival rate based on Kaplan-Meier analysis varied from 83% to 88% in P- patients compared to 36% to 54% in P+ patients. The average hazard ratio for tumor recurrence in patients with P+ compared to P- was 2.67 ± 0.58.

CONCLUSIONS: P+ is an independent negative prognostic factor in primary parotid gland cancer and should be included into the treatment planning.

Original language	English
Pages (from-to)	997-1008
Number of pages	12
Journal	Head & neck
Volume	43
Issue number	3
Early online date	9 Nov 2020
DOIs	https://doi.org/10.1002/hed.26541
Publication status	Published - Mar 2021

Keywords

clinical significance
intraparotid lymph node metastasis
nodal metastasis
prevalence
primary parotid cancer
survival

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Guntinas-Lichius, O., Thielker, J., Robbins, K. T., Olsen, K. D., Shaha, A. R., Mäkitie, A. A., de Bree, R., Vander Poorten, V., Quer, M., Rinaldo, A., Kowalski, L. P., Rodrigo, J. P., Hamoir, M., & Ferlito, A. (2021). Prognostic role of intraparotid lymph node metastasis in primary parotid cancer: Systematic review. Head & neck, 43(3), 997-1008. https://doi.org/10.1002/hed.26541

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title = "Prognostic role of intraparotid lymph node metastasis in primary parotid cancer: Systematic review",

abstract = "BACKGROUND: The prognostic importance of intraparotid lymph node metastasis (P+) in patients with primary parotid gland carcinoma is unclear.METHODS: Nineteen retrospective and noncomparative cohort studies, published between 1992 and 2020, met the inclusion criteria and included 2202 patients for this systematic review.RESULTS: The pooled prevalence of the P in adult patients in the unselected studies was 24.10% (95% confidence interval = 17.95-30.25). The number of P+ lymph nodes per patient was counted in only three studies and ranged from 1 to 11. The 5-year recurrence-free survival rate based on Kaplan-Meier analysis varied from 83% to 88% in P- patients compared to 36% to 54% in P+ patients. The average hazard ratio for tumor recurrence in patients with P+ compared to P- was 2.67 ± 0.58.CONCLUSIONS: P+ is an independent negative prognostic factor in primary parotid gland cancer and should be included into the treatment planning.",

keywords = "clinical significance, intraparotid lymph node metastasis, nodal metastasis, prevalence, primary parotid cancer, survival",

author = "Orlando Guntinas-Lichius and Jovanna Thielker and Robbins, {K Thomas} and Olsen, {Kerry D} and Shaha, {Ashok R} and M{\"a}kitie, {Antti A} and {de Bree}, Remco and {Vander Poorten}, Vincent and Miquel Quer and Alessandra Rinaldo and Kowalski, {Luiz Paulo} and Rodrigo, {Juan Pablo} and Marc Hamoir and Alfio Ferlito",

note = "Publisher Copyright: {\textcopyright} 2020 The Authors. Head & Neck published by Wiley Periodicals LLC. Copyright: Copyright 2021 Elsevier B.V., All rights reserved. Publisher Copyright: {\textcopyright} 2020 The Authors. Head & Neck published by Wiley Periodicals LLC.",

year = "2021",

month = mar,

doi = "10.1002/hed.26541",

language = "English",

volume = "43",

pages = "997--1008",

journal = "Head & neck",

issn = "1043-3074",

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T1 - Prognostic role of intraparotid lymph node metastasis in primary parotid cancer

T2 - Systematic review

AU - Guntinas-Lichius, Orlando

AU - Thielker, Jovanna

AU - Robbins, K Thomas

AU - Olsen, Kerry D

AU - Shaha, Ashok R

AU - Mäkitie, Antti A

AU - de Bree, Remco

AU - Vander Poorten, Vincent

AU - Quer, Miquel

AU - Rinaldo, Alessandra

AU - Kowalski, Luiz Paulo

AU - Rodrigo, Juan Pablo

AU - Hamoir, Marc

AU - Ferlito, Alfio

N1 - Publisher Copyright: © 2020 The Authors. Head & Neck published by Wiley Periodicals LLC. Copyright: Copyright 2021 Elsevier B.V., All rights reserved. Publisher Copyright: © 2020 The Authors. Head & Neck published by Wiley Periodicals LLC.

PY - 2021/3

Y1 - 2021/3

N2 - BACKGROUND: The prognostic importance of intraparotid lymph node metastasis (P+) in patients with primary parotid gland carcinoma is unclear.METHODS: Nineteen retrospective and noncomparative cohort studies, published between 1992 and 2020, met the inclusion criteria and included 2202 patients for this systematic review.RESULTS: The pooled prevalence of the P in adult patients in the unselected studies was 24.10% (95% confidence interval = 17.95-30.25). The number of P+ lymph nodes per patient was counted in only three studies and ranged from 1 to 11. The 5-year recurrence-free survival rate based on Kaplan-Meier analysis varied from 83% to 88% in P- patients compared to 36% to 54% in P+ patients. The average hazard ratio for tumor recurrence in patients with P+ compared to P- was 2.67 ± 0.58.CONCLUSIONS: P+ is an independent negative prognostic factor in primary parotid gland cancer and should be included into the treatment planning.

AB - BACKGROUND: The prognostic importance of intraparotid lymph node metastasis (P+) in patients with primary parotid gland carcinoma is unclear.METHODS: Nineteen retrospective and noncomparative cohort studies, published between 1992 and 2020, met the inclusion criteria and included 2202 patients for this systematic review.RESULTS: The pooled prevalence of the P in adult patients in the unselected studies was 24.10% (95% confidence interval = 17.95-30.25). The number of P+ lymph nodes per patient was counted in only three studies and ranged from 1 to 11. The 5-year recurrence-free survival rate based on Kaplan-Meier analysis varied from 83% to 88% in P- patients compared to 36% to 54% in P+ patients. The average hazard ratio for tumor recurrence in patients with P+ compared to P- was 2.67 ± 0.58.CONCLUSIONS: P+ is an independent negative prognostic factor in primary parotid gland cancer and should be included into the treatment planning.

KW - clinical significance

KW - intraparotid lymph node metastasis

KW - nodal metastasis

KW - prevalence

KW - primary parotid cancer

KW - survival

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U2 - 10.1002/hed.26541

DO - 10.1002/hed.26541

M3 - Review article

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SN - 1043-3074

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JO - Head & neck

JF - Head & neck

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ER -

Prognostic role of intraparotid lymph node metastasis in primary parotid cancer: Systematic review

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