@article{81b92593167e4dde96af83a8e0d4d521,
title = "Prognostic importance of lymph node count and ratio in rectal cancer after neoadjuvant chemoradiotherapy: Results from a cross-sectional study",
abstract = "BACKGROUND: The aim of this study was to determine the prognostic value of lymph node count (LNC) and lymph node ratio (LNR) in rectal cancer after neoadjuvant chemoradiotherapy (CRT).METHODS: Patients who underwent neoadjuvant CRT and total mesorectal excision (TME) for Stage I-III rectal cancer were selected from a cross-sectional study including 71 Dutch centres. Primary outcome parameters were disease-free survival (DFS) and overall survival (OS). Prognostic significance of LNC and LNR (cut-off values 0.15, 0.20, 0.30) was tested for different (sub)groups.RESULTS: From 2095 registered patients, 458 were included, of which 240 patients with LNC < 12 and 218 patients with LNC ≥ 12. LNC was not significantly associated with DFS (p = 0.35) and OS (p = 0.59). In univariable analysis, LNR was significantly associated with DFS and OS in the whole cohort and LNC subgroups, but not in multivariable analysis.CONCLUSIONS: LNC was not associated with long-term oncological outcome in rectal cancer patients treated with CRT, nor was LNR when corrected for N-stage. However, LNR might be used to identify subgroups of node-positive patients with a favourable outcome.",
keywords = "chemoradiotherapy, disease-free survival, lymph nodes, rectal cancer, survival, Multivariate Analysis, Prognosis, Cross-Sectional Studies, Humans, Survival Rate, Lymphatic Metastasis, Disease-Free Survival, Lymph Nodes/pathology, Neoadjuvant Therapy, Retrospective Studies, Neoplasm Staging, Netherlands/epidemiology, Rectal Neoplasms/mortality",
author = "Robin Detering and Meyer, {Vincent M.} and Borstlap, {Wernard A.A.} and Beets-Tan, {Regina G.H.} and Marijnen, {Corrie A.M.} and Roel Hompes and Tanis, {Pieter J.} and {van Westreenen}, {Henderik L.} and Aalbers, {A. G.J.} and Y. Acherman and Algie, {G. D.} and {Alting von Geusau}, B. and F. Amelung and Aukema, {T. S.} and Bakker, {I. S.} and Bartels, {S. A.} and S. Basha and Bastiaansen, {A. J.N.M.} and E. Belgers and W. Bleeker and J. Blok and Bosker, {R. J.I.} and Bosmans, {J. W.} and Boute, {M. C.} and Bouvy, {N. D.} and H. Bouwman and A. Brandt-Kerkhof and Brinkman, {D. J.} and S. Bruin and Bruns, {E. R.J.} and Burbach, {J. P.M.} and Burger, {J. W.A.} and Buskens, {C. J.} and S. Clermonts and {de Graaf}, {E. J.R.} and Dekker, {J. W.T.} and {Van Grevenstein}, {W. M.U.} and J. Heemskerk and P. Janssen and Kool, {M. E.} and Kuiper, {J. T.} and Lange, {J. F.} and N. Schouten and N. Smakman and E. Steller and E. Stortelder and {van de Ven}, {A. W.H.} and {van den Berg}, C. and {van Kessel}, C. and Wouters, {M. W.}",
note = "Funding Information: This study was conducted by the Dutch Snapshot Research Group (DSRG) and the authors would like to thank all registrars for retrospective collecting data in participating Dutch hospitals. The Snapshot study group received a research grant from the Dutch Cancer Society for their work in the past. Author P.J.T. received an unrestricted research grant from Allergan (LifeCell). Publisher Copyright: {\textcopyright} 2021 Wiley Periodicals LLC {\textcopyright} 2021 Wiley Periodicals LLC.",
year = "2021",
month = sep,
day = "1",
doi = "10.1002/jso.26522",
language = "English",
volume = "124",
pages = "367--377",
journal = "Journal of Surgical Oncology",
issn = "0022-4790",
publisher = "Wiley-Liss Inc.",
number = "3",
}