Prognostic imaging variables for recurrent laryngeal and hypopharyngeal carcinoma treated with primary chemoradiotherapy: A systematic and meta-analysis

Hilde J.G. Smits; Sanam Assili; Frans Kauw; Marielle E.P. Philippens; Remco de Bree; Jan W. Dankbaar

doi:10.1002/hed.26698

Prognostic imaging variables for recurrent laryngeal and hypopharyngeal carcinoma treated with primary chemoradiotherapy: A systematic and meta-analysis

Hilde J.G. Smits^*, Sanam Assili, Frans Kauw, Marielle E.P. Philippens, Remco de Bree, Jan W. Dankbaar

^*Corresponding author for this work

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Abstract

Background: In this systematic review, we aim to identify prognostic imaging variables of recurrent laryngeal or hypopharyngeal carcinoma after chemoradiotherapy. Methods: A systematic search was performed in PubMed and EMBASE (1990–2020). The crude data and effect estimates were extracted for each imaging variable. The level of evidence of each variable was assessed and pooled risk ratios (RRs) were calculated. Results: Twenty-two articles were included in this review, 17 on computed tomography (CT) and 5 on magnetic resonance imaging (MRI) variables. We found strong evidence for the prognostic value of tumor volume at various cut-off points (pooled RRs ranging from 2.09 to 3.03). Anterior commissure involvement (pooled RR 2.19), posterior commissure involvement (pooled RR 2.44), subglottic extension (pooled RR 2.25), and arytenoid cartilage extension (pooled RR 2.10) were also strong prognostic factors. Conclusion: Pretreatment tumor volume and involvement of several subsites are prognostic factors for recurrent laryngeal or hypopharyngeal carcinoma after chemoradiotherapy.

Original language	English
Pages (from-to)	2202-2215
Number of pages	14
Journal	Head and Neck
Volume	43
Issue number	7
DOIs	https://doi.org/10.1002/hed.26698
Publication status	Published - Jul 2021

Keywords

computed tomography
laryngeal carcinoma
magnetic resonance imaging
prognosis
recurrence
Hypopharyngeal Neoplasms/diagnostic imaging
Prognosis
Larynx/pathology
Humans
Neoplasm Staging
Chemoradiotherapy

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title = "Prognostic imaging variables for recurrent laryngeal and hypopharyngeal carcinoma treated with primary chemoradiotherapy: A systematic and meta-analysis",

abstract = "Background: In this systematic review, we aim to identify prognostic imaging variables of recurrent laryngeal or hypopharyngeal carcinoma after chemoradiotherapy. Methods: A systematic search was performed in PubMed and EMBASE (1990–2020). The crude data and effect estimates were extracted for each imaging variable. The level of evidence of each variable was assessed and pooled risk ratios (RRs) were calculated. Results: Twenty-two articles were included in this review, 17 on computed tomography (CT) and 5 on magnetic resonance imaging (MRI) variables. We found strong evidence for the prognostic value of tumor volume at various cut-off points (pooled RRs ranging from 2.09 to 3.03). Anterior commissure involvement (pooled RR 2.19), posterior commissure involvement (pooled RR 2.44), subglottic extension (pooled RR 2.25), and arytenoid cartilage extension (pooled RR 2.10) were also strong prognostic factors. Conclusion: Pretreatment tumor volume and involvement of several subsites are prognostic factors for recurrent laryngeal or hypopharyngeal carcinoma after chemoradiotherapy.",

keywords = "computed tomography, laryngeal carcinoma, magnetic resonance imaging, prognosis, recurrence, Hypopharyngeal Neoplasms/diagnostic imaging, Prognosis, Larynx/pathology, Humans, Neoplasm Staging, Chemoradiotherapy",

author = "Smits, {Hilde J.G.} and Sanam Assili and Frans Kauw and Philippens, {Marielle E.P.} and {de Bree}, Remco and Dankbaar, {Jan W.}",

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year = "2021",

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AU - Smits, Hilde J.G.

AU - Assili, Sanam

AU - Kauw, Frans

AU - Philippens, Marielle E.P.

AU - de Bree, Remco

AU - Dankbaar, Jan W.

PY - 2021/7

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N2 - Background: In this systematic review, we aim to identify prognostic imaging variables of recurrent laryngeal or hypopharyngeal carcinoma after chemoradiotherapy. Methods: A systematic search was performed in PubMed and EMBASE (1990–2020). The crude data and effect estimates were extracted for each imaging variable. The level of evidence of each variable was assessed and pooled risk ratios (RRs) were calculated. Results: Twenty-two articles were included in this review, 17 on computed tomography (CT) and 5 on magnetic resonance imaging (MRI) variables. We found strong evidence for the prognostic value of tumor volume at various cut-off points (pooled RRs ranging from 2.09 to 3.03). Anterior commissure involvement (pooled RR 2.19), posterior commissure involvement (pooled RR 2.44), subglottic extension (pooled RR 2.25), and arytenoid cartilage extension (pooled RR 2.10) were also strong prognostic factors. Conclusion: Pretreatment tumor volume and involvement of several subsites are prognostic factors for recurrent laryngeal or hypopharyngeal carcinoma after chemoradiotherapy.

AB - Background: In this systematic review, we aim to identify prognostic imaging variables of recurrent laryngeal or hypopharyngeal carcinoma after chemoradiotherapy. Methods: A systematic search was performed in PubMed and EMBASE (1990–2020). The crude data and effect estimates were extracted for each imaging variable. The level of evidence of each variable was assessed and pooled risk ratios (RRs) were calculated. Results: Twenty-two articles were included in this review, 17 on computed tomography (CT) and 5 on magnetic resonance imaging (MRI) variables. We found strong evidence for the prognostic value of tumor volume at various cut-off points (pooled RRs ranging from 2.09 to 3.03). Anterior commissure involvement (pooled RR 2.19), posterior commissure involvement (pooled RR 2.44), subglottic extension (pooled RR 2.25), and arytenoid cartilage extension (pooled RR 2.10) were also strong prognostic factors. Conclusion: Pretreatment tumor volume and involvement of several subsites are prognostic factors for recurrent laryngeal or hypopharyngeal carcinoma after chemoradiotherapy.

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KW - laryngeal carcinoma

KW - magnetic resonance imaging

KW - prognosis

KW - recurrence

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KW - Prognosis

KW - Larynx/pathology

KW - Humans

KW - Neoplasm Staging

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Prognostic imaging variables for recurrent laryngeal and hypopharyngeal carcinoma treated with primary chemoradiotherapy: A systematic and meta-analysis

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