Prognostic and predictive immune biomarkers in head and neck cancer

Emma de Ruiter

doi:10.33540/1299

Prognostic and predictive immune biomarkers in head and neck cancer

Emma de Ruiter

Research output: Thesis › Doctoral thesis 1 (Research UU / Graduation UU)

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Abstract

Prognostic and predictive biomarkers are indispensable on the path towards personalized medicine. Comprehensive insight in tumor cell biology and the interplay between tumor cells and their TME is necessary for implementing biomarkers in clinical practice. With the rise of numerous novel targeted (immuno)therapies, robust biomarkers predicting treatment response are needed more than ever. This thesis has contributed to our knowledge about the use of prognostic and predictive biomarkers in HNSCC with a focus on the TME. We emphasized the importance of the accuracy and reproducibility of methods in tissue-based biomarker research, in which the use of digital image analysis could play an important role. Although the incorporation of biomarkers into clinical decision making remains a major challenge, we provided leads for further research towards more personalized care for HNSCC patients.

Original language	English
Awarding Institution	University Medical Center (UMC) Utrecht
Supervisors/Advisors	Terhaard, CHJ, Primary supervisor van Diest, Paul, Supervisor Willems, Stefan, Supervisor
Award date	8 Nov 2022
Publisher	Utrecht University
Print ISBNs	978-94-6419-613-9
DOIs	https://doi.org/10.33540/1299
Publication status	Published - 8 Nov 2022

Keywords

Head and neck cancer
HNSCC
prognostic biomarkers
predictive biomarkers
tumor microenvironment
tumor infiltrating lymphocytes
TILs
PD-L1
LAIR1

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542299-bw-ruiter-4-10 1 - 6368471d35a0bFinal published version, 76.1 MB

https://dspace.library.uu.nl/handle/1874/423723

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title = "Prognostic and predictive immune biomarkers in head and neck cancer",

abstract = "Prognostic and predictive biomarkers are indispensable on the path towards personalized medicine. Comprehensive insight in tumor cell biology and the interplay between tumor cells and their TME is necessary for implementing biomarkers in clinical practice. With the rise of numerous novel targeted (immuno)therapies, robust biomarkers predicting treatment response are needed more than ever. This thesis has contributed to our knowledge about the use of prognostic and predictive biomarkers in HNSCC with a focus on the TME. We emphasized the importance of the accuracy and reproducibility of methods in tissue-based biomarker research, in which the use of digital image analysis could play an important role. Although the incorporation of biomarkers into clinical decision making remains a major challenge, we provided leads for further research towards more personalized care for HNSCC patients.",

keywords = "Head and neck cancer, HNSCC, prognostic biomarkers, predictive biomarkers, tumor microenvironment, tumor infiltrating lymphocytes, TILs, PD-L1, LAIR1",

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AB - Prognostic and predictive biomarkers are indispensable on the path towards personalized medicine. Comprehensive insight in tumor cell biology and the interplay between tumor cells and their TME is necessary for implementing biomarkers in clinical practice. With the rise of numerous novel targeted (immuno)therapies, robust biomarkers predicting treatment response are needed more than ever. This thesis has contributed to our knowledge about the use of prognostic and predictive biomarkers in HNSCC with a focus on the TME. We emphasized the importance of the accuracy and reproducibility of methods in tissue-based biomarker research, in which the use of digital image analysis could play an important role. Although the incorporation of biomarkers into clinical decision making remains a major challenge, we provided leads for further research towards more personalized care for HNSCC patients.

KW - Head and neck cancer

KW - HNSCC

KW - prognostic biomarkers

KW - predictive biomarkers

KW - tumor microenvironment

KW - tumor infiltrating lymphocytes

KW - TILs

KW - PD-L1

KW - LAIR1

U2 - 10.33540/1299

DO - 10.33540/1299

M3 - Doctoral thesis 1 (Research UU / Graduation UU)

SN - 978-94-6419-613-9

PB - Utrecht University

ER -

Prognostic and predictive immune biomarkers in head and neck cancer

Abstract

Keywords

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