Primary Prophylaxis against Pneumocystis carinii Pneumonia

Richard Tarabey, Margriet M.e. Schneider, Andy I.m. Hoepelman, Jan C.c. Borleffs

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review


To the Editor: Schneider et al. (Dec. 24 issue)1 concluded that a single dose (either 480 mg or 960 mg) of trimethoprim-sulfamethoxazole once a day is superior to aerosolized pentamidine once a month for the prevention of Pneumocystis carinii pneumonia (PCP) in patients with human immunodeficiency virus (HIV) infection. All the patients had comparable base-line CD4 cell counts. The authors do not report CD4 cell counts for the follow-up period. Zidovudine,24 which was used by many patients in this study, may increase the CD4 cell count and therefore diminish the risk of PCP. In the three groups of patients,…

Original languageEnglish
Number of pages1
JournalNew England Journal of Medicine
Issue number20
Publication statusPublished - 20 May 1993


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