Primary malignant lymphoma of the uterus: localization in a cervical polyp

Distinction between benign and malignant lymphoid lesions of the uterine cervix can be difficult. Two patients showing atypical lymphoid tissue confined to a uterine cervical polyp are presented. In one patient a non-Hodgkin lymphoma stage IE was diagnosed. Treatment consisted of combination chemotherapy. In a second patient the lesion was classified as atypical lymphoid hyperplasia. No treatment was initiated. The presence of a non-Hodgkin lymphoma in a cervical polyp is extremely rare. Distinction between benign and malignant lymphoid tissue within a cervical polyp can be facilitated by immunohistochemical staining and application of the histological criteria for a reactive nature of such lesions.