TY - JOUR
T1 - Prevotella timonensis Bacteria Associated With Vaginal Dysbiosis Enhance Human Immunodeficiency Virus Type 1 Susceptibility Of Vaginal CD4
+ T Cells
AU - van Teijlingen, Nienke H
AU - van Smoorenburg, Marleen Y
AU - Sarrami-Forooshani, Ramin
AU - Zijlstra-Willems, Esther M
AU - van Hamme, John L
AU - Borgdorff, Hanneke
AU - van de Wijgert, Janneke Hhm
AU - van Leeuwen, Elisabeth
AU - van der Post, Joris A M
AU - Strijbis, Karin
AU - Ribeiro, Carla M S
AU - Geijtenbeek, Teunis B H
N1 - © The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America.
PY - 2024/7/15
Y1 - 2024/7/15
N2 - Dysbiosis of the vaginal microbiome poses a serious risk for sexual human immunodeficiency virus type 1 (HIV-1) transmission. Prevotella spp are abundant during vaginal dysbiosis and associated with enhanced HIV-1 susceptibility; however, underlying mechanisms remain unclear. Here, we investigated the direct effect of vaginal bacteria on HIV-1 susceptibility of vaginal CD4
+ T cells. Notably, pre-exposure to Prevotella timonensis enhanced HIV-1 uptake by vaginal T cells, leading to increased viral fusion and enhanced virus production. Pre-exposure to antiretroviral inhibitors abolished P timonensis–enhanced infection. Our study shows that the vaginal microbiome directly affects mucosal CD4
+ T-cell susceptibility, emphasizing importance of vaginal dysbiosis diagnosis and treatment.
AB - Dysbiosis of the vaginal microbiome poses a serious risk for sexual human immunodeficiency virus type 1 (HIV-1) transmission. Prevotella spp are abundant during vaginal dysbiosis and associated with enhanced HIV-1 susceptibility; however, underlying mechanisms remain unclear. Here, we investigated the direct effect of vaginal bacteria on HIV-1 susceptibility of vaginal CD4
+ T cells. Notably, pre-exposure to Prevotella timonensis enhanced HIV-1 uptake by vaginal T cells, leading to increased viral fusion and enhanced virus production. Pre-exposure to antiretroviral inhibitors abolished P timonensis–enhanced infection. Our study shows that the vaginal microbiome directly affects mucosal CD4
+ T-cell susceptibility, emphasizing importance of vaginal dysbiosis diagnosis and treatment.
KW - CD4 T cells
KW - HIV-1 susceptibility
KW - Prevotella timonensis
KW - microbiome
KW - vaginal dysbiosis
UR - http://www.scopus.com/inward/record.url?scp=85199648606&partnerID=8YFLogxK
U2 - 10.1093/infdis/jiae166
DO - 10.1093/infdis/jiae166
M3 - Article
C2 - 38573164
SN - 0022-1899
VL - 230
SP - e43-e47
JO - The Journal of infectious diseases
JF - The Journal of infectious diseases
IS - 1
M1 - doi.org/10.1093/infdis/jiae166
ER -