Preventing ventriculostomy-related infections with antibiotic-impregnated drains in hospitals: a two-centre Dutch study

J. D M Verberk; J. W Berkelbach vd Sprenkel; M. P. Arts; P. J W Dennesen; M. J M Bonten; M. S M van Mourik

doi:10.1016/j.jhin.2015.12.018

Preventing ventriculostomy-related infections with antibiotic-impregnated drains in hospitals: a two-centre Dutch study

J. D M Verberk, J. W Berkelbach vd Sprenkel, M. P. Arts, P. J W Dennesen, M. J M Bonten, M. S M van Mourik^*

^*Corresponding author for this work

Research output: Contribution to journal › Letter › Academic › peer-review

Abstract

This observational cohort study assessed the effect of the introduction of antibiotic-impregnated external ventricular drains (AI-EVDs), as opposed to plain silicone EVDs, on the occurrence of ventriculostomy-related infections (VRIs) in two Dutch hospitals, with no other changes to their clinical practice. VRI was defined using the criteria of the Centers for Disease Control and Prevention, and with a culture-based definition. A propensity-score-adjusted competing risks survival analysis showed that introduction of AI-EVDs did not significantly decrease the risk of VRIs in routine care, nor affect the bacterial aetiology, even after adjustment for confounding and competing events.

Original language	English
Pages (from-to)	401-404
Number of pages	4
Journal	The journal of Hospital Infection
Volume	92
Issue number	4
DOIs	https://doi.org/10.1016/j.jhin.2015.12.018
Publication status	Published - 1 Apr 2016

Keywords

Antibiotic-impregnated
Competing risks
External ventricular drains
Neurosurgery
Survival
Ventriculostomy-related infection

Access to Document

10.1016/j.jhin.2015.12.018

Cite this

@article{0d58fa2e0bea413dab83ea9b0d1b070c,

title = "Preventing ventriculostomy-related infections with antibiotic-impregnated drains in hospitals: a two-centre Dutch study",

abstract = "This observational cohort study assessed the effect of the introduction of antibiotic-impregnated external ventricular drains (AI-EVDs), as opposed to plain silicone EVDs, on the occurrence of ventriculostomy-related infections (VRIs) in two Dutch hospitals, with no other changes to their clinical practice. VRI was defined using the criteria of the Centers for Disease Control and Prevention, and with a culture-based definition. A propensity-score-adjusted competing risks survival analysis showed that introduction of AI-EVDs did not significantly decrease the risk of VRIs in routine care, nor affect the bacterial aetiology, even after adjustment for confounding and competing events.",

keywords = "Antibiotic-impregnated, Competing risks, External ventricular drains, Neurosurgery, Survival, Ventriculostomy-related infection",

author = "Verberk, {J. D M} and {Berkelbach vd Sprenkel}, {J. W} and Arts, {M. P.} and Dennesen, {P. J W} and Bonten, {M. J M} and {van Mourik}, {M. S M}",

year = "2016",

month = apr,

day = "1",

doi = "10.1016/j.jhin.2015.12.018",

language = "English",

volume = "92",

pages = "401--404",

journal = "The journal of Hospital Infection",

issn = "0195-6701",

publisher = "W.B. Saunders Ltd",

number = "4",

}

TY - JOUR

T1 - Preventing ventriculostomy-related infections with antibiotic-impregnated drains in hospitals

T2 - a two-centre Dutch study

AU - Verberk, J. D M

AU - Berkelbach vd Sprenkel, J. W

AU - Arts, M. P.

AU - Dennesen, P. J W

AU - Bonten, M. J M

AU - van Mourik, M. S M

PY - 2016/4/1

Y1 - 2016/4/1

N2 - This observational cohort study assessed the effect of the introduction of antibiotic-impregnated external ventricular drains (AI-EVDs), as opposed to plain silicone EVDs, on the occurrence of ventriculostomy-related infections (VRIs) in two Dutch hospitals, with no other changes to their clinical practice. VRI was defined using the criteria of the Centers for Disease Control and Prevention, and with a culture-based definition. A propensity-score-adjusted competing risks survival analysis showed that introduction of AI-EVDs did not significantly decrease the risk of VRIs in routine care, nor affect the bacterial aetiology, even after adjustment for confounding and competing events.

AB - This observational cohort study assessed the effect of the introduction of antibiotic-impregnated external ventricular drains (AI-EVDs), as opposed to plain silicone EVDs, on the occurrence of ventriculostomy-related infections (VRIs) in two Dutch hospitals, with no other changes to their clinical practice. VRI was defined using the criteria of the Centers for Disease Control and Prevention, and with a culture-based definition. A propensity-score-adjusted competing risks survival analysis showed that introduction of AI-EVDs did not significantly decrease the risk of VRIs in routine care, nor affect the bacterial aetiology, even after adjustment for confounding and competing events.

KW - Antibiotic-impregnated

KW - Competing risks

KW - External ventricular drains

KW - Neurosurgery

KW - Survival

KW - Ventriculostomy-related infection

UR - http://www.scopus.com/inward/record.url?scp=84977666203&partnerID=8YFLogxK

U2 - 10.1016/j.jhin.2015.12.018

DO - 10.1016/j.jhin.2015.12.018

M3 - Letter

AN - SCOPUS:84977666203

SN - 0195-6701

VL - 92

SP - 401

EP - 404

JO - The journal of Hospital Infection

JF - The journal of Hospital Infection

IS - 4

ER -

Preventing ventriculostomy-related infections with antibiotic-impregnated drains in hospitals: a two-centre Dutch study

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this