TY - JOUR
T1 - Prevalence, risk factors, and long-term outcomes of cerebral ischemia in hospitalized COVID-19 patients - study rationale and protocol of the CORONIS study
T2 - A multicentre prospective cohort study
AU - van Lith, Theresa J
AU - Sluis, Wouter M
AU - Wijers, Naomi T
AU - Meijer, Frederick Ja
AU - Kamphuis-van Ulzen, Karin
AU - de Bresser, Jeroen
AU - Dankbaar, Jan Willem
AU - van den Heuvel, Frederik Ma
AU - Antoni, M Louisa
AU - Mulders-Manders, Catharina M
AU - de Mast, Quirijn
AU - van de Veerdonk, Frank L
AU - Klok, Frederikus A
AU - Tuladhar, Anil M
AU - Cannegieter, Suzanne C
AU - Wermer, Marieke Jh
AU - van der Worp, H Bart
AU - Huisman, Menno V
AU - de Leeuw, Frank-Erik
N1 - Funding Information:
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work is supported by The Netherlands Organisation for Health Research and Development (ZonMw) and The Heart Council (grant number 10430012010014).
Publisher Copyright:
© European Stroke Organisation 2022.
PY - 2022/6
Y1 - 2022/6
N2 - BACKGROUND: COVID-19 is often complicated by thrombo-embolic events including ischemic stroke. The underlying mechanisms of COVID-19-associated ischemic stroke, the incidence and risk factors of silent cerebral ischemia, and the long-term functional outcome in these patients are currently unknown.PATIENTS AND METHODS: CORONavirus and Ischemic Stroke (CORONIS) is a multicentre prospective cohort study investigating the prevalence, risk factors and long-term incidence of (silent) cerebral ischemia, and the long-term functional outcome among patients with COVID-19. We aim to include 200 adult patients hospitalized with COVID-19 without symptomatic ischemic stroke to investigate the prevalence of silent cerebral ischemia compared with 60 (matched) controls with MRI. In addition, we will identify potential risk factors and/or causes of cerebral ischemia in COVID-19 patients with (n = 70) or without symptomatic stroke (n = 200) by means of blood sampling, cardiac workup and brain MRI. We will measure functional outcome and cognitive function after 3 and 12 months with standardized questionnaires in all patients with COVID-19. Finally, the long-term incidence of (new) silent cerebral ischemia in patients with COVID-19 will be assessed with follow up MRI (n = 120).SUMMARY: The CORONIS study is designed to add further insight into the prevalence, long-term incidence and risk factors of cerebral ischemia, and the long-term functional outcome in hospitalized adult patients with COVID-19.
AB - BACKGROUND: COVID-19 is often complicated by thrombo-embolic events including ischemic stroke. The underlying mechanisms of COVID-19-associated ischemic stroke, the incidence and risk factors of silent cerebral ischemia, and the long-term functional outcome in these patients are currently unknown.PATIENTS AND METHODS: CORONavirus and Ischemic Stroke (CORONIS) is a multicentre prospective cohort study investigating the prevalence, risk factors and long-term incidence of (silent) cerebral ischemia, and the long-term functional outcome among patients with COVID-19. We aim to include 200 adult patients hospitalized with COVID-19 without symptomatic ischemic stroke to investigate the prevalence of silent cerebral ischemia compared with 60 (matched) controls with MRI. In addition, we will identify potential risk factors and/or causes of cerebral ischemia in COVID-19 patients with (n = 70) or without symptomatic stroke (n = 200) by means of blood sampling, cardiac workup and brain MRI. We will measure functional outcome and cognitive function after 3 and 12 months with standardized questionnaires in all patients with COVID-19. Finally, the long-term incidence of (new) silent cerebral ischemia in patients with COVID-19 will be assessed with follow up MRI (n = 120).SUMMARY: The CORONIS study is designed to add further insight into the prevalence, long-term incidence and risk factors of cerebral ischemia, and the long-term functional outcome in hospitalized adult patients with COVID-19.
KW - COVID-19
KW - SARS-CoV-2
KW - ischemic stroke
KW - silent cerebral ischemia
UR - http://www.scopus.com/inward/record.url?scp=85129144693&partnerID=8YFLogxK
U2 - 10.1177/23969873221092538
DO - 10.1177/23969873221092538
M3 - Article
C2 - 35647315
SN - 2396-9873
VL - 7
SP - 180
EP - 187
JO - European Stroke Journal
JF - European Stroke Journal
IS - 2
ER -