TY - JOUR
T1 - Prevalence of bladder and bowel dysfunction in duchenne muscular dystrophy using the childhood bladder and bowel dysfunction questionnaire
AU - Lionarons, Judith M.
AU - de Groot, Imelda J.M.
AU - Fock, Johanna M.
AU - Klinkenberg, Sylvia
AU - Vrijens, Desiree M.J.
AU - Vreugdenhil, Anita C.E.
AU - Medici-Van Den Herik, Evita G.
AU - Cuppen, Inge
AU - Jaeger, Bregje
AU - Niks, Erik H.
AU - Hoogerhuis, Rinske
AU - Platte-Van Attekum, Nicky
AU - Feron, Frans J.M.
AU - Faber, Catharina G.
AU - Hendriksen, Jos G.M.
AU - Vles, Johan S.H.
N1 - Funding Information:
Funding: The research was funded by Duchenne Parent Project NL, Spieren voor spieren NL (grant number SvS15-) and the School for Mental Health and Neuroscience of Maastricht University.
Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/7/30
Y1 - 2021/7/30
N2 - Introduction: Lower urinary tract symptoms (LUTS) and gastrointestinal (GI) problems are common in Duchenne muscular dystrophy (DMD), but not systematically assessed in regular care. We aimed to determine the prevalence of bladder and bowel dysfunction (BBD) in DMD patients compared with healthy controls (HC). Methods: The Childhood Bladder and Bowel Dysfunction Questionnaire (CBBDQ) based on the International Rome III criteria and the International Children’s Continence Society was filled out by 57 DMD patients and 56 HC. Additionally, possible associations of BBD with, for example, medication use or quality of life were evaluated in an additional questionnaire developed by experts. Results: In 74% of patients versus 56% of HC ≥1 LUTS (n.s.) were reported, 68% of patients versus 39% of HC reported ≥1 bowel symptom (p = 0.002) and 53% of patients versus 30% of HC reported combined LUTS and bowel symptoms (p = 0.019). A negative impact of BBD on daily life functioning was reported by 42% of patients. Conclusions: These data underscore that standard screening for BBD is needed and that the CBBDQ could be of added value to optimize DMD care.
AB - Introduction: Lower urinary tract symptoms (LUTS) and gastrointestinal (GI) problems are common in Duchenne muscular dystrophy (DMD), but not systematically assessed in regular care. We aimed to determine the prevalence of bladder and bowel dysfunction (BBD) in DMD patients compared with healthy controls (HC). Methods: The Childhood Bladder and Bowel Dysfunction Questionnaire (CBBDQ) based on the International Rome III criteria and the International Children’s Continence Society was filled out by 57 DMD patients and 56 HC. Additionally, possible associations of BBD with, for example, medication use or quality of life were evaluated in an additional questionnaire developed by experts. Results: In 74% of patients versus 56% of HC ≥1 LUTS (n.s.) were reported, 68% of patients versus 39% of HC reported ≥1 bowel symptom (p = 0.002) and 53% of patients versus 30% of HC reported combined LUTS and bowel symptoms (p = 0.019). A negative impact of BBD on daily life functioning was reported by 42% of patients. Conclusions: These data underscore that standard screening for BBD is needed and that the CBBDQ could be of added value to optimize DMD care.
KW - Bladder and bowel dysfunction
KW - Constipation
KW - Duchenne muscular dystrophy
KW - Lower urinary tract symptoms
KW - Urinary incontinence
UR - http://www.scopus.com/inward/record.url?scp=85111716303&partnerID=8YFLogxK
U2 - 10.3390/life11080772
DO - 10.3390/life11080772
M3 - Article
C2 - 34440515
AN - SCOPUS:85111716303
VL - 11
JO - Life
JF - Life
IS - 8
M1 - 772
ER -