TY - JOUR
T1 - Prevalence and risk factors of cancer-related fatigue in childhood cancer survivors
T2 - A DCCSS LATER study
AU - van Deuren, Sylvia
AU - Penson, Adriaan
AU - van Dulmen-den Broeder, Eline
AU - Grootenhuis, Martha A
AU - van der Heiden-van der Loo, Margriet
AU - Bronkhorst, Ewald
AU - Blijlevens, Nicole M A
AU - Streefkerk, Nina
AU - Teepen, Jop C
AU - Tissing, Wim J E
AU - van der Pal, Helena J H
AU - van den Heuvel-Eibrink, Marry M
AU - Versluys, Birgitta A B
AU - Bresters, Dorine
AU - van Leeuwen, Flora E
AU - Ronckers, Cécile M
AU - Kremer, Leontien C M
AU - Knoop, Hans
AU - Loonen, Jacqueline J
N1 - Funding Information:
This work was supported by the Dutch Cancer Society (KUN 2014‐6985). The work of Nina Streefkerk was also financially supported by the Dutch Cancer Society (grant UVA2014‐6805).
Publisher Copyright:
© 2021 The Authors. Cancer published by Wiley Periodicals LLC on behalf of American Cancer Society
PY - 2022/3/1
Y1 - 2022/3/1
N2 - BACKGROUND: Cancer-related fatigue is a debilitating late effect after treatment for childhood cancer. The prevalence of fatigue in childhood cancer survivors (CCSs) and associated factors for fatigue has varied widely in previous studies. Two important aspects of cancer-related fatigue, its severity and chronicity, are often not assessed. This study investigated the prevalence of, and risk factors for, severe chronic fatigue (CF) in a national cohort of Dutch CCSs.METHODS: In this study, 2810 CCSs (5-year survivors of all childhood malignancies diagnosed between 1963 and 2001 with a current age of 12-65 years) and 1040 sibling controls were included. CF was assessed with the Short Fatigue Questionnaire and was defined as a score ≥ 18 and persistence of fatigue for ≥6 months. Cancer- and treatment-related characteristics, current health problems, and demographic and lifestyle variables were assessed as potential risk factors for CF via multivariable logistic regression analyses.RESULTS: In adult CCSs and sibling controls (≥18 years old), the prevalence of CF was 26.1% and 14.1%, respectively (P < .001). In adolescent CCSs and sibling controls (<18 years old), the prevalence of CF was 10.9% and 3.2%, respectively. Female gender (odds ratio [OR], 2.13; 95% confidence interval [CI], 1.73-2.62), unemployment (OR, 2.18; 95% CI, 1.67-2.85), having 1 or more health problems (OR for 1-2, 1.48; 95% CI, 1.18-1.87; OR for >2, 2.20; 95% CI, 1.50-3.21), and a central nervous system diagnosis (OR, 1.74; 95% CI, 1.17-2.60) were significantly associated with CF in adult CCSs.CONCLUSIONS: This study shows that CCSs, regardless of their cancer diagnosis, report CF more often than sibling controls. This study provides new evidence for the prevalence of fatigue in CCSs.
AB - BACKGROUND: Cancer-related fatigue is a debilitating late effect after treatment for childhood cancer. The prevalence of fatigue in childhood cancer survivors (CCSs) and associated factors for fatigue has varied widely in previous studies. Two important aspects of cancer-related fatigue, its severity and chronicity, are often not assessed. This study investigated the prevalence of, and risk factors for, severe chronic fatigue (CF) in a national cohort of Dutch CCSs.METHODS: In this study, 2810 CCSs (5-year survivors of all childhood malignancies diagnosed between 1963 and 2001 with a current age of 12-65 years) and 1040 sibling controls were included. CF was assessed with the Short Fatigue Questionnaire and was defined as a score ≥ 18 and persistence of fatigue for ≥6 months. Cancer- and treatment-related characteristics, current health problems, and demographic and lifestyle variables were assessed as potential risk factors for CF via multivariable logistic regression analyses.RESULTS: In adult CCSs and sibling controls (≥18 years old), the prevalence of CF was 26.1% and 14.1%, respectively (P < .001). In adolescent CCSs and sibling controls (<18 years old), the prevalence of CF was 10.9% and 3.2%, respectively. Female gender (odds ratio [OR], 2.13; 95% confidence interval [CI], 1.73-2.62), unemployment (OR, 2.18; 95% CI, 1.67-2.85), having 1 or more health problems (OR for 1-2, 1.48; 95% CI, 1.18-1.87; OR for >2, 2.20; 95% CI, 1.50-3.21), and a central nervous system diagnosis (OR, 1.74; 95% CI, 1.17-2.60) were significantly associated with CF in adult CCSs.CONCLUSIONS: This study shows that CCSs, regardless of their cancer diagnosis, report CF more often than sibling controls. This study provides new evidence for the prevalence of fatigue in CCSs.
KW - cancer-related fatigue
KW - childhood cancer survivors
KW - late effects
KW - survivorship
UR - http://www.scopus.com/inward/record.url?scp=85118388286&partnerID=8YFLogxK
U2 - 10.1002/cncr.33993
DO - 10.1002/cncr.33993
M3 - Article
C2 - 34724201
SN - 0008-543X
VL - 128
SP - 1110
EP - 1121
JO - Cancer
JF - Cancer
IS - 5
ER -