Preparation of biodegradable polylactide microparticles via a biocompatible procedure

Riccardo Levato; Miguel A Mateos-Timoneda; Josep A Planell

doi:10.1002/mabi.201100383

Preparation of biodegradable polylactide microparticles via a biocompatible procedure

Riccardo Levato, Miguel A Mateos-Timoneda, Josep A Planell

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

PLA MPs are prepared via a novel and toxic-chemical-free fabrication route using ethyl lactate, a green solvent and FDA-approved aroma. MPs are obtained by a solution jet break-up and solvent displacement method. Adjusting flow parameters allows the tuning of MPs size between 60 and 180 µm, with reduced polydispersity. Morphological analysis shows microporous particles with Janus-like surface. A fluorophore is successfully loaded into the MPs during their formation step. This versatile green solvent-based procedure is proven to be suitable for drug encapsulation and delivery applications. The method may be extended to different droplet generation techniques.

Original language	English
Pages (from-to)	557-66
Number of pages	10
Journal	Macromolecular Bioscience
Volume	12
Issue number	4
DOIs	https://doi.org/10.1002/mabi.201100383
Publication status	Published - Apr 2012
Externally published	Yes

Keywords

Biocompatible Materials
Drug Carriers
Drug Compounding
Fluorescent Dyes
Green Chemistry Technology
Humans
Lactates
Microscopy, Electron, Scanning
Microspheres
Particle Size
Polyesters
Porosity
Rhodamines
Solvents
Viscosity
Journal Article
Research Support, Non-U.S. Gov't

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10.1002/mabi.201100383

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title = "Preparation of biodegradable polylactide microparticles via a biocompatible procedure",

abstract = "PLA MPs are prepared via a novel and toxic-chemical-free fabrication route using ethyl lactate, a green solvent and FDA-approved aroma. MPs are obtained by a solution jet break-up and solvent displacement method. Adjusting flow parameters allows the tuning of MPs size between 60 and 180 µm, with reduced polydispersity. Morphological analysis shows microporous particles with Janus-like surface. A fluorophore is successfully loaded into the MPs during their formation step. This versatile green solvent-based procedure is proven to be suitable for drug encapsulation and delivery applications. The method may be extended to different droplet generation techniques.",

keywords = "Biocompatible Materials, Drug Carriers, Drug Compounding, Fluorescent Dyes, Green Chemistry Technology, Humans, Lactates, Microscopy, Electron, Scanning, Microspheres, Particle Size, Polyesters, Porosity, Rhodamines, Solvents, Viscosity, Journal Article, Research Support, Non-U.S. Gov't",

author = "Riccardo Levato and Mateos-Timoneda, {Miguel A} and Planell, {Josep A}",

note = "Copyright {\textcopyright} 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.",

year = "2012",

month = apr,

doi = "10.1002/mabi.201100383",

language = "English",

volume = "12",

pages = "557--66",

journal = "Macromolecular Bioscience",

issn = "1616-5187",

publisher = "Wiley-VCH Verlag",

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T1 - Preparation of biodegradable polylactide microparticles via a biocompatible procedure

AU - Levato, Riccardo

AU - Mateos-Timoneda, Miguel A

AU - Planell, Josep A

PY - 2012/4

Y1 - 2012/4

N2 - PLA MPs are prepared via a novel and toxic-chemical-free fabrication route using ethyl lactate, a green solvent and FDA-approved aroma. MPs are obtained by a solution jet break-up and solvent displacement method. Adjusting flow parameters allows the tuning of MPs size between 60 and 180 µm, with reduced polydispersity. Morphological analysis shows microporous particles with Janus-like surface. A fluorophore is successfully loaded into the MPs during their formation step. This versatile green solvent-based procedure is proven to be suitable for drug encapsulation and delivery applications. The method may be extended to different droplet generation techniques.

AB - PLA MPs are prepared via a novel and toxic-chemical-free fabrication route using ethyl lactate, a green solvent and FDA-approved aroma. MPs are obtained by a solution jet break-up and solvent displacement method. Adjusting flow parameters allows the tuning of MPs size between 60 and 180 µm, with reduced polydispersity. Morphological analysis shows microporous particles with Janus-like surface. A fluorophore is successfully loaded into the MPs during their formation step. This versatile green solvent-based procedure is proven to be suitable for drug encapsulation and delivery applications. The method may be extended to different droplet generation techniques.

KW - Biocompatible Materials

KW - Drug Carriers

KW - Drug Compounding

KW - Fluorescent Dyes

KW - Green Chemistry Technology

KW - Humans

KW - Lactates

KW - Microscopy, Electron, Scanning

KW - Microspheres

KW - Particle Size

KW - Polyesters

KW - Porosity

KW - Rhodamines

KW - Solvents

KW - Viscosity

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1002/mabi.201100383

DO - 10.1002/mabi.201100383

M3 - Article

C2 - 22362713

SN - 1616-5187

VL - 12

SP - 557

EP - 566

JO - Macromolecular Bioscience

JF - Macromolecular Bioscience

IS - 4

ER -

Preparation of biodegradable polylactide microparticles via a biocompatible procedure

Abstract

Keywords

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