TY - JOUR
T1 - Preoperative MRI brain phenotypes are related to postoperative delirium in older individuals
AU - Kant, Ilse M J
AU - Slooter, Arjen J C
AU - Jaarsma-Coes, Myriam
AU - van Montfort, Simone J T
AU - Witkamp, Theo D
AU - Pasma, Wietze
AU - Hendrikse, Jeroen
AU - de Bresser, Jeroen
N1 - Funding Information:
The research leading to these results has received funding from the European Union funded seventh framework research program (FP7 2007e2013) under grant agreement no. 602461/HEALTH-F2- 2014-60246 , BioCog (Biomarker Development for Postoperative Cognitive Impairment in the Elderly), www.biocog.eu . The funder had no role in study design, collection, analysis and interpretation of data, in writing of the report and in the decision to submit the article for publication.
Publisher Copyright:
© 2021
PY - 2021/5
Y1 - 2021/5
N2 - The underlying structural correlates of predisposition to postoperative delirium remain largely unknown. A combined analysis of preoperative brain magnetic resonance imaging (MRI) markers could improve our understanding of the pathophysiology of delirium. Therefore, we aimed to identify different MRI brain phenotypes in older patients scheduled for major elective surgery, and to assess the relation between these phenotypes and postoperative delirium. Markers of neurodegenerative and neurovascular brain changes were determined from MRI brain scans in older patients (n = 161, mean age 71, standard deviation 5 years), of whom 24 (15%) developed delirium. A hierarchical cluster analysis was performed. We found six distinct groups of patients with different MRI brain phenotypes. Logistic regression analysis showed a higher odds of developing postoperative delirium in individuals with multi-burden pathology (n = 15 (9%), odds ratio (95% confidence interval): 3.8 (1.1-13.0)). In conclusion, these results indicate that different MRI brain phenotypes are related to a different risk of developing delirium after major elective surgery. MRI brain phenotypes could assist in an improved understanding of the structural correlates of predisposition to postoperative delirium.
AB - The underlying structural correlates of predisposition to postoperative delirium remain largely unknown. A combined analysis of preoperative brain magnetic resonance imaging (MRI) markers could improve our understanding of the pathophysiology of delirium. Therefore, we aimed to identify different MRI brain phenotypes in older patients scheduled for major elective surgery, and to assess the relation between these phenotypes and postoperative delirium. Markers of neurodegenerative and neurovascular brain changes were determined from MRI brain scans in older patients (n = 161, mean age 71, standard deviation 5 years), of whom 24 (15%) developed delirium. A hierarchical cluster analysis was performed. We found six distinct groups of patients with different MRI brain phenotypes. Logistic regression analysis showed a higher odds of developing postoperative delirium in individuals with multi-burden pathology (n = 15 (9%), odds ratio (95% confidence interval): 3.8 (1.1-13.0)). In conclusion, these results indicate that different MRI brain phenotypes are related to a different risk of developing delirium after major elective surgery. MRI brain phenotypes could assist in an improved understanding of the structural correlates of predisposition to postoperative delirium.
KW - Brain phenotypes
KW - Delirium
KW - Encephalopathy
KW - MRI
UR - http://www.scopus.com/inward/record.url?scp=85101616401&partnerID=8YFLogxK
U2 - 10.1016/j.neurobiolaging.2021.01.033
DO - 10.1016/j.neurobiolaging.2021.01.033
M3 - Article
C2 - 33647523
SN - 0197-4580
VL - 101
SP - 247
EP - 255
JO - Neurobiology of Aging
JF - Neurobiology of Aging
ER -