TY - JOUR
T1 - Prenatal maternal and cord blood vitamin D concentrations and negative affectivity in infancy
AU - Sammallahti, Sara
AU - Holmlund-Suila, Elisa
AU - Zou, Runyu
AU - Valkama, Saara
AU - Rosendahl, Jenni
AU - Enlund-Cerullo, Maria
AU - Hauta-alus, Helena
AU - Lahti-Pulkkinen, Marius
AU - El Marroun, Hanan
AU - Tiemeier, Henning
AU - Mäkitie, Outi
AU - Andersson, Sture
AU - Räikkönen, Katri
AU - Heinonen, Kati
N1 - Funding Information:
The general design of the Generation R Study was supported by the Netherlands Organization for Scientific Research (NWO) and the Dutch Ministry of Health, Welfare, and Sport. The work of the authors involved in the Generation R Study in this project was supported by the LEaDing Fellows EU Marie Skłodowska-Curie COFUND Programme and the Orion Research Foundation (Dr Sammallahti); NWO Vici Grant 016.VICI.170.200 (Dr Tiemeier); and Stichting Volksbond Rotterdam, the Brain & Behavior Research Foundation NARSAD Young Investigator Grant 27853, and the European Union's Horizon 2020 Research and Innovation Program LifeCycle grant No. 733206 (Dr El Marroun). The work of the authors involved in the VIDI study in this project was supported by the Academy of Finland (Dr Heinonen [grant n:o 345057]; Dr Outi Mäkitie, and Dr Lahti-Pulkkinen), by the Sigrid Jusélius Foundation and the Novo Nordisk Foundation (Dr Outi Mäkitie), by the Päivikki and Sakari Sohlberg Foundation and the Juho Vainio Foundation (Dr Hauta-alus), by the Victoriastiftelsen, the Instrumentarium Science Foundation, the Paulo Foundation, and the Orion Research Foundation (Dr Enlund-Cerullo), and by Grants from Special Governmental Subsidy to Clinical Research, the Foundation for Pediatric Research in Finland, and Finska Läkaresällskapet (Dr Andersson). The funding sources had no role in study design, data collection and analysis, the interpretation or reporting of the results, or the decision to submit the manuscript for publication.
Publisher Copyright:
© 2021, The Author(s).
PY - 2023/4
Y1 - 2023/4
N2 - Higher maternal vitamin D concentration during pregnancy is associated with better child mental health. Negative affectivity, an early-emerging temperamental trait, indicates an increased risk of psychopathology. We investigated if maternal early/mid-pregnancy 25-hydroxyvitamin D (25(OH)D) and neonatal cord blood 25(OH)D concentrations are associated with Negative affectivity in infancy. We studied term-born infants from the vitamin D Intervention in Infants study (VIDI, n = 777, follow-up rate 80%, Finland), and the Generation R Study (n = 1505, follow-up rate 40%, Netherlands). We measured maternal serum 25(OH)D at 6–27 weeks (VIDI) or 18–25 weeks (Generation R) of pregnancy, and cord blood 25(OH)D at birth (both cohorts). Caregivers rated infant Negative affectivity at 11.7 months (VIDI) or 6.5 months (Generation R) using the Revised Infant Behavior Questionnaire. Using linear regression, we tested associations between 25(OH)D and Negative affectivity adjusted for infant age, sex, season of 25(OH)D measurement, maternal age, education, smoking, and body-mass-index. Per 10 nmol/l increase in maternal early/mid-pregnancy 25(OH)D, infant Negative affectivity decreased by 0.02 standard deviations (95% confidence interval [CI] − 0.06, − 0.004) in VIDI, and 0.03 standard deviations (95% CI − 0.03, − 0.01) in Generation R. Cord blood 25(OH)D was associated with Negative affectivity in Generation R (− 0.03, 95% CI − 0.05, − 0.01), but not VIDI (0.00, 95% CI − 0.02, 0.02). Lower maternal 25(OH)D concentrations were consistently associated with higher infant Negative affectivity, while associations between cord blood 25(OH)D concentrations and Negative affectivity were less clear. Maternal vitamin D status during early- and mid-pregnancy may be linked with early-emerging differences in offspring behavior.
AB - Higher maternal vitamin D concentration during pregnancy is associated with better child mental health. Negative affectivity, an early-emerging temperamental trait, indicates an increased risk of psychopathology. We investigated if maternal early/mid-pregnancy 25-hydroxyvitamin D (25(OH)D) and neonatal cord blood 25(OH)D concentrations are associated with Negative affectivity in infancy. We studied term-born infants from the vitamin D Intervention in Infants study (VIDI, n = 777, follow-up rate 80%, Finland), and the Generation R Study (n = 1505, follow-up rate 40%, Netherlands). We measured maternal serum 25(OH)D at 6–27 weeks (VIDI) or 18–25 weeks (Generation R) of pregnancy, and cord blood 25(OH)D at birth (both cohorts). Caregivers rated infant Negative affectivity at 11.7 months (VIDI) or 6.5 months (Generation R) using the Revised Infant Behavior Questionnaire. Using linear regression, we tested associations between 25(OH)D and Negative affectivity adjusted for infant age, sex, season of 25(OH)D measurement, maternal age, education, smoking, and body-mass-index. Per 10 nmol/l increase in maternal early/mid-pregnancy 25(OH)D, infant Negative affectivity decreased by 0.02 standard deviations (95% confidence interval [CI] − 0.06, − 0.004) in VIDI, and 0.03 standard deviations (95% CI − 0.03, − 0.01) in Generation R. Cord blood 25(OH)D was associated with Negative affectivity in Generation R (− 0.03, 95% CI − 0.05, − 0.01), but not VIDI (0.00, 95% CI − 0.02, 0.02). Lower maternal 25(OH)D concentrations were consistently associated with higher infant Negative affectivity, while associations between cord blood 25(OH)D concentrations and Negative affectivity were less clear. Maternal vitamin D status during early- and mid-pregnancy may be linked with early-emerging differences in offspring behavior.
KW - Infant mental health
KW - Negative affectivity
KW - Nutrition
KW - Prenatal
KW - Temperament
KW - Vitamin D
UR - http://www.scopus.com/inward/record.url?scp=85117710746&partnerID=8YFLogxK
U2 - 10.1007/s00787-021-01894-4
DO - 10.1007/s00787-021-01894-4
M3 - Article
C2 - 34657965
AN - SCOPUS:85117710746
SN - 1018-8827
VL - 32
SP - 601
EP - 609
JO - European Child and Adolescent Psychiatry
JF - European Child and Adolescent Psychiatry
IS - 4
ER -