Prenatal and Neonatal Infections of the Central Nervous System

Linda S. de Vries; Vincent Bekker; Sylke J. Steggerda

doi:10.1016/j.pcl.2025.05.003

Prenatal and Neonatal Infections of the Central Nervous System

Linda S. de Vries^*
, Vincent Bekker
, Sylke J. Steggerda

^*Corresponding author for this work

Birth Center Neonatology - Medical

Research output: Contribution to journal › Review article › peer-review

Abstract

Bacterial, fungal, and viral infections of the central nervous system of the newborn are uncommon but severe and can result in devastating brain injury. These pathogens have their own pattern of brain lesions. Cranial ultrasound and MRI can, therefore, already suggest the causative pathogen. Brain lesions can evolve and repeat neuro-imaging is important to either diagnose abscess formation, cystic evolution, or hydrocephalus. Outcome varies considerably among the different pathogens, and long-term follow-up is recommended.

Original language	English
Pages (from-to)	825-842
Number of pages	18
Journal	Pediatric Clinics of North America
Volume	72
Issue number	5
Early online date	23 Jul 2025
DOIs	https://doi.org/10.1016/j.pcl.2025.05.003
Publication status	Published - Oct 2025

Keywords

CNS infection
Cranial ultrasound
MRI
Neuro-imaging
Newborn

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10.1016/j.pcl.2025.05.003

1-s2.0-S0031395525000537-mainFinal published version, 17.5 MBLicence: Taverne

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title = "Prenatal and Neonatal Infections of the Central Nervous System",

abstract = "Bacterial, fungal, and viral infections of the central nervous system of the newborn are uncommon but severe and can result in devastating brain injury. These pathogens have their own pattern of brain lesions. Cranial ultrasound and MRI can, therefore, already suggest the causative pathogen. Brain lesions can evolve and repeat neuro-imaging is important to either diagnose abscess formation, cystic evolution, or hydrocephalus. Outcome varies considerably among the different pathogens, and long-term follow-up is recommended.",

keywords = "CNS infection, Cranial ultrasound, MRI, Neuro-imaging, Newborn",

author = "\{de Vries\}, \{Linda S.\} and Vincent Bekker and Steggerda, \{Sylke J.\}",

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T1 - Prenatal and Neonatal Infections of the Central Nervous System

AU - de Vries, Linda S.

AU - Bekker, Vincent

AU - Steggerda, Sylke J.

PY - 2025/10

Y1 - 2025/10

N2 - Bacterial, fungal, and viral infections of the central nervous system of the newborn are uncommon but severe and can result in devastating brain injury. These pathogens have their own pattern of brain lesions. Cranial ultrasound and MRI can, therefore, already suggest the causative pathogen. Brain lesions can evolve and repeat neuro-imaging is important to either diagnose abscess formation, cystic evolution, or hydrocephalus. Outcome varies considerably among the different pathogens, and long-term follow-up is recommended.

AB - Bacterial, fungal, and viral infections of the central nervous system of the newborn are uncommon but severe and can result in devastating brain injury. These pathogens have their own pattern of brain lesions. Cranial ultrasound and MRI can, therefore, already suggest the causative pathogen. Brain lesions can evolve and repeat neuro-imaging is important to either diagnose abscess formation, cystic evolution, or hydrocephalus. Outcome varies considerably among the different pathogens, and long-term follow-up is recommended.

KW - CNS infection

KW - Cranial ultrasound

KW - MRI

KW - Neuro-imaging

KW - Newborn

UR - https://www.scopus.com/pages/publications/105011406000

U2 - 10.1016/j.pcl.2025.05.003

DO - 10.1016/j.pcl.2025.05.003

M3 - Review article

AN - SCOPUS:105011406000

SN - 0031-3955

VL - 72

SP - 825

EP - 842

JO - Pediatric Clinics of North America

JF - Pediatric Clinics of North America

IS - 5

ER -

Prenatal and Neonatal Infections of the Central Nervous System

Abstract

Keywords

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