@article{31e827aa747f4609b35516f65c3cddf3,
title = "Preliminary stop of the TOPical Imiquimod treatment of high-grade Cervical intraepithelial neoplasia (TOPIC) trial",
abstract = "The {"}TOPical Imiquimod treatment of high-grade Cervical intraepithelial neoplasia{"} (TOPIC) trial was stopped preliminary, due to lagging inclusions. This study aimed to evaluate the treatment efficacy and clinical applicability of imiquimod 5\% cream in high-grade cervical intraepithelial neoplasia (CIN). The lagging inclusions were mainly due to a strong patient preference for either of the two treatment modalities. This prompted us to initiate a new study on the same subject, with a non-randomized, open-label design: the 'TOPical Imiquimod treatment of high-grade Cervical intraepithelial neoplasia (TOPIC)-3' study. Original TOPIC-trial: Medical Ethics Committee approval number METC13231; ClinicalTrials.gov Identifier: NCT02329171, 22 December 2014. TOPIC-3 study: Medical Ethics Committee approval number METC162025; ClinicalTrials.gov Identifier: NCT02917746, 16 September 2016.",
keywords = "Biological markers, Cervical intraepithelial neoplasia, Human papillomavirus, Imiquimod, Natural history",
author = "Koeneman, \{M. M.\} and Kruse, \{A. J.\} and Kooreman, \{L. F S\} and \{zur Hausen\}, A. and Hopman, \{A. H N\} and Sep, \{S. J S\} and \{Van Gorp\}, T. and Slangen, \{B. F M\} and \{van Beekhuizen\}, \{H. J.\} and \{van de Sande\}, \{A. J M\} and Gerestein, \{C. G.\} and Nijman, \{H. W.\} and Kruitwagen, \{R. F P M\}",
note = "Funding Information: The authors declare that they have no competing interests. This study and manuscript preparation were funded by the Academic Hospital of Maastricht (Academic Fund) and MedaPharma. Both funding bodies were not involved in the study design and will not be involved in the collection, analysis, and interpretation of data, in the writing of the manuscript and in the decision to submit the manuscript for publication. Funding Information: This study and manuscript preparation were funded by the Academic Hospital of Maastricht (Academic Fund) and MedaPharma. Both funding bodies were not involved in the study design and will not be involved in the collection, analysis, and interpretation of data, in the writing of the manuscript and in the decision to submit the manuscript for publication. Publisher Copyright: {\textcopyright} 2017 The Author(s).",
year = "2017",
month = feb,
day = "7",
doi = "10.1186/s12885-017-3108-9",
language = "English",
volume = "17",
journal = "BMC Cancer",
issn = "1471-2407",
publisher = "BioMed Central",
}