TY - JOUR
T1 - Preeclampsia and genetic risk factors for thrombosis
T2 - A case-control study
AU - De Groot, Christianne J.M.
AU - Bloemenkamp, Kitty W.M.
AU - Duvekot, Ella J.
AU - Helmerhorst, Frans M.
AU - Bertina, Rogier M.
AU - Van Der Meer, Felix
AU - De Ronde, Hans
AU - Oei, S. Guid
AU - Kanhai, Humphrey H.H.
AU - Rosendaal, Frits R.
PY - 1999/1/1
Y1 - 1999/1/1
N2 - OBJECTIVE: Recently, it has been proposed that hereditary coagulation abnormalities leading to an increased venous thrombosis risk may play a role in the development of preeclampsia. We tested this hypothesis in women who have had preeclampsia compared with matched control subjects. STUDY DESIGN: We conducted a case-control study of 163 women with preeclampsia during 1991- 1996. Control subjects were matched for age and delivery date. Patients and control subjects were tested for the presence of factor V Leiden, prothrombin 20210A allele, protein C, protein S, and antithrombin deficiency. Logistic regression methods were used for data analysis. RESULTS: The prevalence of these genetic risk factors was similar in the patient group (12.9%) and the control group (12.9%; odds ratio, 1.0; 95% confidence interval, 0.5-3.9). Unexpectedly, we found a high prevalence of factor V Leiden in the control group (9.2%). CONCLUSION: We found no differences in the prevalence of genetic risk factors of thrombosis in women with preeclampsia compared with control subjects.
AB - OBJECTIVE: Recently, it has been proposed that hereditary coagulation abnormalities leading to an increased venous thrombosis risk may play a role in the development of preeclampsia. We tested this hypothesis in women who have had preeclampsia compared with matched control subjects. STUDY DESIGN: We conducted a case-control study of 163 women with preeclampsia during 1991- 1996. Control subjects were matched for age and delivery date. Patients and control subjects were tested for the presence of factor V Leiden, prothrombin 20210A allele, protein C, protein S, and antithrombin deficiency. Logistic regression methods were used for data analysis. RESULTS: The prevalence of these genetic risk factors was similar in the patient group (12.9%) and the control group (12.9%; odds ratio, 1.0; 95% confidence interval, 0.5-3.9). Unexpectedly, we found a high prevalence of factor V Leiden in the control group (9.2%). CONCLUSION: We found no differences in the prevalence of genetic risk factors of thrombosis in women with preeclampsia compared with control subjects.
KW - Antithrombin deficiency
KW - Factor V Leiden
KW - Hereditary coagulation abnormalities
KW - Preeclampsia
KW - Prothrombin 20210A allele
UR - http://www.scopus.com/inward/record.url?scp=0032740843&partnerID=8YFLogxK
U2 - 10.1016/S0002-9378(99)70335-2
DO - 10.1016/S0002-9378(99)70335-2
M3 - Article
C2 - 10521764
AN - SCOPUS:0032740843
SN - 0002-9378
VL - 181
SP - 975
EP - 980
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
IS - 4
ER -