Predictive impact of allele-matching and EBMT risk score for outcome after T-cell depleted unrelated donor transplantation in poor-risk acute leukemia and myelodysplasia

T. Lodewijck; M. Oudshoorn; B. van der Holt; E.J. Petersen; H.T. Spierings; P.A. von dem Borne; A. Schattenberg; W. Allebes; M. Groenendijk-Sijnke; L. Duinhouwer; R. Willemze; B. Löwenberg; L.F. Verdonck; E. Meijer; J.J. Cornelissen

doi:10.1038/leu.2011.123

Predictive impact of allele-matching and EBMT risk score for outcome after T-cell depleted unrelated donor transplantation in poor-risk acute leukemia and myelodysplasia

T. Lodewijck, M. Oudshoorn, B. van der Holt, E.J. Petersen, H.T. Spierings, P.A. von dem Borne, A. Schattenberg, W. Allebes, M. Groenendijk-Sijnke, L. Duinhouwer, R. Willemze, B. Löwenberg, L.F. Verdonck, E. Meijer, J.J. Cornelissen

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Many parameters predict for outcome after unrelated donor (URD) allogeneic hematopoietic stem cell transplantation (alloSCT). High-resolution HLA-matching significantly impacts outcome and also the European Group of Blood and Marrow Transplantation (EBMT) risk score, based on patient age, disease stage, donor type, time from diagnosis to SCT and gender combination, may predict for non-relapse mortality and overall survival (OS). We evaluated the individual and combined effects of allele-matching and the EBMT risk score in 327 patients with poor-risk acute leukemia or myelodysplasia, who received a T-cell depleted URD alloSCT. Matching for HLA-A, -B, -C and -DRB1 alleles (8/8 match) was associated with a 5-year OS of 40% compared with 30% for mismatched (⩽7/8) pairs (P=0.02). Patients with EBMT risk scores of 1–2, 3, 4 and 5–7 had 5-year OS estimates of 53, 43, 30 and 20%, respectively (P

Original language	English
Pages (from-to)	1548-1554
Number of pages	7
Journal	Leukemia
Volume	25
Issue number	10
DOIs	https://doi.org/10.1038/leu.2011.123
Publication status	Published - 2011

Access to Document

10.1038/leu.2011.123

http://www.ncbi.nlm.nih.gov/pubmed/21606965

Cite this

Lodewijck, T., Oudshoorn, M., van der Holt, B., Petersen, E. J., Spierings, H. T., von dem Borne, P. A., Schattenberg, A., Allebes, W., Groenendijk-Sijnke, M., Duinhouwer, L., Willemze, R., Löwenberg, B., Verdonck, L. F., Meijer, E., & Cornelissen, J. J. (2011). Predictive impact of allele-matching and EBMT risk score for outcome after T-cell depleted unrelated donor transplantation in poor-risk acute leukemia and myelodysplasia. Leukemia, 25(10), 1548-1554. https://doi.org/10.1038/leu.2011.123

@article{e8aec4e8693d4f529009a087315fa858,

title = "Predictive impact of allele-matching and EBMT risk score for outcome after T-cell depleted unrelated donor transplantation in poor-risk acute leukemia and myelodysplasia",

abstract = "Many parameters predict for outcome after unrelated donor (URD) allogeneic hematopoietic stem cell transplantation (alloSCT). High-resolution HLA-matching significantly impacts outcome and also the European Group of Blood and Marrow Transplantation (EBMT) risk score, based on patient age, disease stage, donor type, time from diagnosis to SCT and gender combination, may predict for non-relapse mortality and overall survival (OS). We evaluated the individual and combined effects of allele-matching and the EBMT risk score in 327 patients with poor-risk acute leukemia or myelodysplasia, who received a T-cell depleted URD alloSCT. Matching for HLA-A, -B, -C and -DRB1 alleles (8/8 match) was associated with a 5-year OS of 40% compared with 30% for mismatched (⩽7/8) pairs (P=0.02). Patients with EBMT risk scores of 1–2, 3, 4 and 5–7 had 5-year OS estimates of 53, 43, 30 and 20%, respectively (P",

author = "T. Lodewijck and M. Oudshoorn and {van der Holt}, B. and E.J. Petersen and H.T. Spierings and {von dem Borne}, P.A. and A. Schattenberg and W. Allebes and M. Groenendijk-Sijnke and L. Duinhouwer and R. Willemze and B. L{\"o}wenberg and L.F. Verdonck and E. Meijer and J.J. Cornelissen",

year = "2011",

doi = "10.1038/leu.2011.123",

language = "English",

volume = "25",

pages = "1548--1554",

journal = "Leukemia",

issn = "0887-6924",

publisher = "Springer Nature",

number = "10",

}

Lodewijck, T, Oudshoorn, M, van der Holt, B, Petersen, EJ, Spierings, HT, von dem Borne, PA, Schattenberg, A, Allebes, W, Groenendijk-Sijnke, M, Duinhouwer, L, Willemze, R, Löwenberg, B, Verdonck, LF, Meijer, E & Cornelissen, JJ 2011, 'Predictive impact of allele-matching and EBMT risk score for outcome after T-cell depleted unrelated donor transplantation in poor-risk acute leukemia and myelodysplasia', Leukemia, vol. 25, no. 10, pp. 1548-1554. https://doi.org/10.1038/leu.2011.123

TY - JOUR

T1 - Predictive impact of allele-matching and EBMT risk score for outcome after T-cell depleted unrelated donor transplantation in poor-risk acute leukemia and myelodysplasia

AU - Lodewijck, T.

AU - Oudshoorn, M.

AU - van der Holt, B.

AU - Petersen, E.J.

AU - Spierings, H.T.

AU - von dem Borne, P.A.

AU - Schattenberg, A.

AU - Allebes, W.

AU - Groenendijk-Sijnke, M.

AU - Duinhouwer, L.

AU - Willemze, R.

AU - Löwenberg, B.

AU - Verdonck, L.F.

AU - Meijer, E.

AU - Cornelissen, J.J.

PY - 2011

Y1 - 2011

N2 - Many parameters predict for outcome after unrelated donor (URD) allogeneic hematopoietic stem cell transplantation (alloSCT). High-resolution HLA-matching significantly impacts outcome and also the European Group of Blood and Marrow Transplantation (EBMT) risk score, based on patient age, disease stage, donor type, time from diagnosis to SCT and gender combination, may predict for non-relapse mortality and overall survival (OS). We evaluated the individual and combined effects of allele-matching and the EBMT risk score in 327 patients with poor-risk acute leukemia or myelodysplasia, who received a T-cell depleted URD alloSCT. Matching for HLA-A, -B, -C and -DRB1 alleles (8/8 match) was associated with a 5-year OS of 40% compared with 30% for mismatched (⩽7/8) pairs (P=0.02). Patients with EBMT risk scores of 1–2, 3, 4 and 5–7 had 5-year OS estimates of 53, 43, 30 and 20%, respectively (P

AB - Many parameters predict for outcome after unrelated donor (URD) allogeneic hematopoietic stem cell transplantation (alloSCT). High-resolution HLA-matching significantly impacts outcome and also the European Group of Blood and Marrow Transplantation (EBMT) risk score, based on patient age, disease stage, donor type, time from diagnosis to SCT and gender combination, may predict for non-relapse mortality and overall survival (OS). We evaluated the individual and combined effects of allele-matching and the EBMT risk score in 327 patients with poor-risk acute leukemia or myelodysplasia, who received a T-cell depleted URD alloSCT. Matching for HLA-A, -B, -C and -DRB1 alleles (8/8 match) was associated with a 5-year OS of 40% compared with 30% for mismatched (⩽7/8) pairs (P=0.02). Patients with EBMT risk scores of 1–2, 3, 4 and 5–7 had 5-year OS estimates of 53, 43, 30 and 20%, respectively (P

U2 - 10.1038/leu.2011.123

DO - 10.1038/leu.2011.123

M3 - Article

SN - 0887-6924

VL - 25

SP - 1548

EP - 1554

JO - Leukemia

JF - Leukemia

IS - 10

ER -

Predictive impact of allele-matching and EBMT risk score for outcome after T-cell depleted unrelated donor transplantation in poor-risk acute leukemia and myelodysplasia

Abstract

Access to Document

Fingerprint

Cite this