Abstract
BACKGROUND: The aim of this article was to develop prediction models that calculate postoperative 2- and 5-year mortality probabilities of patients with squamous cell carcinoma of the maxilla (MSCC).
METHODS: Data were collected from the medical records of patients who had been operated between 2000 and 2015 for MSCC. Potential clinical and histopathological predictors were identified. Confounding-(un)adjusted multivariate Cox and logistic regression models were computed with stepwise backward selection. Internal validation was performed to assess calibration and discriminatory ability.
RESULTS: Ninety-five patients with MSCC were included. Two-year follow-up was complete, and 85 patients had 5-year follow-up. Age, neck treatment, surgical margins, bone invasion, spindle growth, and vasoinvasive growth were associated with mortality. Models were adjusted for confounding with Charlson's comorbidities index. C-indexes were .841 and .770 respectively, and .838 and .749 after bootstrapping.
CONCLUSION: The MSCC-specific mortality probability can be calculated with new prediction models.
| Original language | English |
|---|---|
| Pages (from-to) | 3584-3593 |
| Number of pages | 10 |
| Journal | Head & neck |
| Volume | 41 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - 1 Oct 2019 |
Keywords
- head and neck cancer
- maxillary squamous cell carcinoma
- mortality
- oral cancer
- prediction model
- prognosis
- webcalculator