Prediagnostic Blood Metal Levels and the Risk of Parkinson's Disease: A Large European Prospective Cohort

Yujia Zhao; Anushree Ray; Karin Broberg; Maria Kippler; Christina M. Lill; Paolo Vineis; Verena A. Katzke; Miguel Rodriguez-Barranco; María Dolores Chirlaque; Marcela Guevara; Jesús Humberto Gómez; Johnni Hansen; Salvatore Panico; Lefkos T. Middleton; Giovanna Masala; Valeria Pala; Ana Vinagre-Aragon; Maurizio Zibetti; Roel Vermeulen; Susan Peters

doi:10.1002/mds.29602

Prediagnostic Blood Metal Levels and the Risk of Parkinson's Disease: A Large European Prospective Cohort

Yujia Zhao
, Anushree Ray
, Karin Broberg
, Maria Kippler
, Christina M. Lill
, Paolo Vineis
, Verena A. Katzke
, Miguel Rodriguez-Barranco
, María Dolores Chirlaque
, Marcela Guevara
, Jesús Humberto Gómez
, Johnni Hansen
, Salvatore Panico
, Lefkos T. Middleton
, Giovanna Masala
, Valeria Pala
, Ana Vinagre-Aragon
, Maurizio Zibetti
, Roel Vermeulen
, Susan Peters^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Background: Metals have been postulated as environmental concerns in the etiology of Parkinson's disease (PD), but metal levels are typically measured after diagnosis, which might be subject to reverse causality. Objective: The aim of this study was to investigate the association between prediagnostic blood metal levels and PD risk. Methods: A case-control study was nested in a prospective European cohort, using erythrocyte samples collected before PD diagnosis. Results: Most assessed metals were not associated with PD risk. Cadmium has a suggestive negative association with PD (odds ratio [95% confidence interval] for the highest quartile, 0.70 [0.42–1.17]), which diminished among never smokers. Among current smokers only, lead was associated with decreased PD risk (0.06 [0.01–0.35]), whereas arsenic showed associations toward an increased PD risk (1.85 [0.45–7.93]). Conclusions: We observe no strong evidence to support a role of metals in the development of PD. In particular, smoking may confound the association with tobacco-derived metals.

Original language	English
Pages (from-to)	2302-2307
Number of pages	6
Journal	Movement Disorders
Volume	38
Issue number	12
DOIs	https://doi.org/10.1002/mds.29602
Publication status	Published - Dec 2023

Keywords

cohort study
metals
Parkinson's disease
prospective exposure assessment

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10.1002/mds.29602Licence: CC BY-NC-ND

Movement Disorders - 2023 - Zhao - Prediagnostic Blood Metal Levels and the Risk of Parkinson s Disease A Large EuropeanFinal published version, 299 KBLicence: CC BY-NC-ND

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Zhao, Y., Ray, A., Broberg, K., Kippler, M., Lill, C. M., Vineis, P., Katzke, V. A., Rodriguez-Barranco, M., Chirlaque, M. D., Guevara, M., Gómez, J. H., Hansen, J., Panico, S., Middleton, L. T., Masala, G., Pala, V., Vinagre-Aragon, A., Zibetti, M., Vermeulen, R., & Peters, S. (2023). Prediagnostic Blood Metal Levels and the Risk of Parkinson's Disease: A Large European Prospective Cohort. Movement Disorders, 38(12), 2302-2307. https://doi.org/10.1002/mds.29602

@article{e1dfbdcf418e4316a77a7b76124cf70f,

title = "Prediagnostic Blood Metal Levels and the Risk of Parkinson's Disease: A Large European Prospective Cohort",

abstract = "Background: Metals have been postulated as environmental concerns in the etiology of Parkinson's disease (PD), but metal levels are typically measured after diagnosis, which might be subject to reverse causality. Objective: The aim of this study was to investigate the association between prediagnostic blood metal levels and PD risk. Methods: A case-control study was nested in a prospective European cohort, using erythrocyte samples collected before PD diagnosis. Results: Most assessed metals were not associated with PD risk. Cadmium has a suggestive negative association with PD (odds ratio [95\% confidence interval] for the highest quartile, 0.70 [0.42–1.17]), which diminished among never smokers. Among current smokers only, lead was associated with decreased PD risk (0.06 [0.01–0.35]), whereas arsenic showed associations toward an increased PD risk (1.85 [0.45–7.93]). Conclusions: We observe no strong evidence to support a role of metals in the development of PD. In particular, smoking may confound the association with tobacco-derived metals.",

keywords = "cohort study, metals, Parkinson's disease, prospective exposure assessment",

author = "Yujia Zhao and Anushree Ray and Karin Broberg and Maria Kippler and Lill, \{Christina M.\} and Paolo Vineis and Katzke, \{Verena A.\} and Miguel Rodriguez-Barranco and Chirlaque, \{Mar{\'i}a Dolores\} and Marcela Guevara and G{\'o}mez, \{Jes{\'u}s Humberto\} and Johnni Hansen and Salvatore Panico and Middleton, \{Lefkos T.\} and Giovanna Masala and Valeria Pala and Ana Vinagre-Aragon and Maurizio Zibetti and Roel Vermeulen and Susan Peters",

note = "Publisher Copyright: {\textcopyright} 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.",

year = "2023",

month = dec,

doi = "10.1002/mds.29602",

language = "English",

volume = "38",

pages = "2302--2307",

journal = "Movement Disorders",

issn = "0885-3185",

publisher = "John Wiley \& Sons Inc.",

number = "12",

}

Zhao, Y, Ray, A, Broberg, K, Kippler, M, Lill, CM, Vineis, P, Katzke, VA, Rodriguez-Barranco, M, Chirlaque, MD, Guevara, M, Gómez, JH, Hansen, J, Panico, S, Middleton, LT, Masala, G, Pala, V, Vinagre-Aragon, A, Zibetti, M, Vermeulen, R & Peters, S 2023, 'Prediagnostic Blood Metal Levels and the Risk of Parkinson's Disease: A Large European Prospective Cohort', Movement Disorders, vol. 38, no. 12, pp. 2302-2307. https://doi.org/10.1002/mds.29602

TY - JOUR

T1 - Prediagnostic Blood Metal Levels and the Risk of Parkinson's Disease

T2 - A Large European Prospective Cohort

AU - Zhao, Yujia

AU - Ray, Anushree

AU - Broberg, Karin

AU - Kippler, Maria

AU - Lill, Christina M.

AU - Vineis, Paolo

AU - Katzke, Verena A.

AU - Rodriguez-Barranco, Miguel

AU - Chirlaque, María Dolores

AU - Guevara, Marcela

AU - Gómez, Jesús Humberto

AU - Hansen, Johnni

AU - Panico, Salvatore

AU - Middleton, Lefkos T.

AU - Masala, Giovanna

AU - Pala, Valeria

AU - Vinagre-Aragon, Ana

AU - Zibetti, Maurizio

AU - Vermeulen, Roel

AU - Peters, Susan

PY - 2023/12

Y1 - 2023/12

N2 - Background: Metals have been postulated as environmental concerns in the etiology of Parkinson's disease (PD), but metal levels are typically measured after diagnosis, which might be subject to reverse causality. Objective: The aim of this study was to investigate the association between prediagnostic blood metal levels and PD risk. Methods: A case-control study was nested in a prospective European cohort, using erythrocyte samples collected before PD diagnosis. Results: Most assessed metals were not associated with PD risk. Cadmium has a suggestive negative association with PD (odds ratio [95% confidence interval] for the highest quartile, 0.70 [0.42–1.17]), which diminished among never smokers. Among current smokers only, lead was associated with decreased PD risk (0.06 [0.01–0.35]), whereas arsenic showed associations toward an increased PD risk (1.85 [0.45–7.93]). Conclusions: We observe no strong evidence to support a role of metals in the development of PD. In particular, smoking may confound the association with tobacco-derived metals.

AB - Background: Metals have been postulated as environmental concerns in the etiology of Parkinson's disease (PD), but metal levels are typically measured after diagnosis, which might be subject to reverse causality. Objective: The aim of this study was to investigate the association between prediagnostic blood metal levels and PD risk. Methods: A case-control study was nested in a prospective European cohort, using erythrocyte samples collected before PD diagnosis. Results: Most assessed metals were not associated with PD risk. Cadmium has a suggestive negative association with PD (odds ratio [95% confidence interval] for the highest quartile, 0.70 [0.42–1.17]), which diminished among never smokers. Among current smokers only, lead was associated with decreased PD risk (0.06 [0.01–0.35]), whereas arsenic showed associations toward an increased PD risk (1.85 [0.45–7.93]). Conclusions: We observe no strong evidence to support a role of metals in the development of PD. In particular, smoking may confound the association with tobacco-derived metals.

KW - cohort study

KW - metals

KW - Parkinson's disease

KW - prospective exposure assessment

UR - https://www.scopus.com/pages/publications/85170553703

U2 - 10.1002/mds.29602

DO - 10.1002/mds.29602

M3 - Article

C2 - 37675653

AN - SCOPUS:85170553703

SN - 0885-3185

VL - 38

SP - 2302

EP - 2307

JO - Movement Disorders

JF - Movement Disorders

IS - 12

ER -

Prediagnostic Blood Metal Levels and the Risk of Parkinson's Disease: A Large European Prospective Cohort

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