Practice patterns in the management of bacterial keratitis: a five-continent survey

Simon Wespiser; Emilia Koestel; Thibaut Fabacher; Arnaud Sauer; Florent Aptel; Louis Arnould; Rimvydas Asoklis; Stephanie Baillif; Christophe Baudouin; Pierre Henri Becmeur; Diane Bernheim; Zsolt Bocksei; Vincent Borderie; Nacim Bouheraoua; Jean Louis Bourges; Alain Bron; Carole Burillon; Nicole Carnt; Christophe Chiquet; Beatrice Cochener; Isabelle Cochereau; Catherine Creuzot-Garcher; Thierry David; Paolo Fogagnolo; Lea Dormegny; Pierre Fournie; David Gaucher; Philippe Gohier; Gabrielle Gomart; Christina Grupcheva; Julie Gueudry; Gaëlle Ho Wang Yin; Louis Hoffart; Saskia Imhof; Renata Ivekovic; Juliette Knoeri; Laurent Kodjikian; Julie Kosacki; Marc Labetoulle; Jean Marc Legeais; Rafael Martinez-Costa; Gordana Megevand-Sunaric; Arnaud Messerlin; Laurent Meyer; Nicolas Meyer; Harold Merle; Frédéric Mouriaux; Marc Muraine; Giorgio Porro; Robert Wisse

doi:10.1007/s00417-023-06003-6

Practice patterns in the management of bacterial keratitis: a five-continent survey

Simon Wespiser
, Emilia Koestel^*
, Thibaut Fabacher
, Arnaud Sauer
, Florent Aptel
, Louis Arnould
, Rimvydas Asoklis
, Stephanie Baillif
, Christophe Baudouin
, Pierre Henri Becmeur
, Diane Bernheim
, Zsolt Bocksei
, Vincent Borderie
, Nacim Bouheraoua
, Jean Louis Bourges
, Alain Bron
, Carole Burillon
, Nicole Carnt
, Christophe Chiquet
, Beatrice Cochener

Isabelle Cochereau, Catherine Creuzot-Garcher, Thierry David, Paolo Fogagnolo, Lea Dormegny, Pierre Fournie, David Gaucher, Philippe Gohier, Gabrielle Gomart, Christina Grupcheva, Julie Gueudry, Gaëlle Ho Wang Yin, Louis Hoffart, Saskia Imhof, Renata Ivekovic, Juliette Knoeri, Laurent Kodjikian, Julie Kosacki, Marc Labetoulle, Jean Marc Legeais, Rafael Martinez-Costa, Gordana Megevand-Sunaric, Arnaud Messerlin, Laurent Meyer, Nicolas Meyer, Harold Merle, Frédéric Mouriaux, Marc Muraine, Giorgio Porro, Robert Wisse,

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

PURPOSE: To assess the current diagnostic and therapeutic practice patterns in early management of bacterial keratitis over five continents.

METHODS: Between March and August 2019, we distributed an online survey including two clinical scenarios of bacterial keratitis, namely, a mild case and severe case, to 2936 ophthalmologists from 144 countries around the world. The survey consisted of 29 questions. We performed descriptive statistics and a comparative analysis of the answers according to the participants' continent of practice, practice setting, seniority, and subspecialty.

RESULTS: We received 237 surveys from 54 countries (8% response rate). The proportion of respondents performing microbiological investigations was higher in North America, Asia, Europe, and Oceania than Africa and South America (p < 0.05). This ratio was also higher among ocular surface specialists than for other ophthalmologists (p < 0.001). For mild cases, fluoroquinolone monotherapy and a combination of two or more antibiotics were prescribed by 46% and 41% respondents, respectively. For severe cases, fluoroquinolone monotherapy and a combination of antibiotics were prescribed by 20% and 78% respondents, respectively. Fluoroquinolone monotherapy was the most commonly prescribed treatment in South America, Africa, and Oceania. A combination of two antibiotics was preferentially prescribed in the rest of the world. Topical steroids were prescribed in both circumstances, respectively, in 72% and 75% of cases.

CONCLUSION: Our results highlight essential geographical disparities in the current management of bacterial keratitis over five continents.

Original language	English
Pages (from-to)	1961-1969
Number of pages	9
Journal	Graefe's Archive for Clinical and Experimental Ophthalmology
Volume	261
Issue number	7
DOIs	https://doi.org/10.1007/s00417-023-06003-6
Publication status	Published - Jul 2023

Keywords

Antibiotics
Bacterial keratitis
Diagnosis
Survey
Treatment

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10.1007/s00417-023-06003-6

s00417-023-06003-6Final published version, 999 KBLicence: Taverne

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Wespiser, S., Koestel, E., Fabacher, T., Sauer, A., Aptel, F., Arnould, L., Asoklis, R., Baillif, S., Baudouin, C., Becmeur, P. H., Bernheim, D., Bocksei, Z., Borderie, V., Bouheraoua, N., Bourges, J. L., Bron, A., Burillon, C., Carnt, N., Chiquet, C. (2023). Practice patterns in the management of bacterial keratitis: a five-continent survey. Graefe's Archive for Clinical and Experimental Ophthalmology, 261(7), 1961-1969. https://doi.org/10.1007/s00417-023-06003-6

@article{eed6e8ce59c6499ebce9fa03597698db,

title = "Practice patterns in the management of bacterial keratitis: a five-continent survey",

abstract = "PURPOSE: To assess the current diagnostic and therapeutic practice patterns in early management of bacterial keratitis over five continents.METHODS: Between March and August 2019, we distributed an online survey including two clinical scenarios of bacterial keratitis, namely, a mild case and severe case, to 2936 ophthalmologists from 144 countries around the world. The survey consisted of 29 questions. We performed descriptive statistics and a comparative analysis of the answers according to the participants' continent of practice, practice setting, seniority, and subspecialty.RESULTS: We received 237 surveys from 54 countries (8\% response rate). The proportion of respondents performing microbiological investigations was higher in North America, Asia, Europe, and Oceania than Africa and South America (p < 0.05). This ratio was also higher among ocular surface specialists than for other ophthalmologists (p < 0.001). For mild cases, fluoroquinolone monotherapy and a combination of two or more antibiotics were prescribed by 46\% and 41\% respondents, respectively. For severe cases, fluoroquinolone monotherapy and a combination of antibiotics were prescribed by 20\% and 78\% respondents, respectively. Fluoroquinolone monotherapy was the most commonly prescribed treatment in South America, Africa, and Oceania. A combination of two antibiotics was preferentially prescribed in the rest of the world. Topical steroids were prescribed in both circumstances, respectively, in 72\% and 75\% of cases.CONCLUSION: Our results highlight essential geographical disparities in the current management of bacterial keratitis over five continents.",

keywords = "Antibiotics, Bacterial keratitis, Diagnosis, Survey, Treatment",

author = "Simon Wespiser and Emilia Koestel and Thibaut Fabacher and Arnaud Sauer and Florent Aptel and Louis Arnould and Rimvydas Asoklis and Stephanie Baillif and Christophe Baudouin and Becmeur, \{Pierre Henri\} and Diane Bernheim and Zsolt Bocksei and Vincent Borderie and Nacim Bouheraoua and Bourges, \{Jean Louis\} and Alain Bron and Carole Burillon and Nicole Carnt and Christophe Chiquet and Beatrice Cochener and Isabelle Cochereau and Catherine Creuzot-Garcher and Thierry David and Paolo Fogagnolo and Lea Dormegny and Pierre Fournie and David Gaucher and Philippe Gohier and Gabrielle Gomart and Christina Grupcheva and Julie Gueudry and \{Ho Wang Yin\}, Ga{\"e}lle and Louis Hoffart and Saskia Imhof and Renata Ivekovic and Juliette Knoeri and Laurent Kodjikian and Julie Kosacki and Marc Labetoulle and Legeais, \{Jean Marc\} and Rafael Martinez-Costa and Gordana Megevand-Sunaric and Arnaud Messerlin and Laurent Meyer and Nicolas Meyer and Harold Merle and Fr{\'e}d{\'e}ric Mouriaux and Marc Muraine and Giorgio Porro and Robert Wisse",

note = "Publisher Copyright: {\textcopyright} 2023, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.",

year = "2023",

month = jul,

doi = "10.1007/s00417-023-06003-6",

language = "English",

volume = "261",

pages = "1961--1969",

journal = "Graefe's Archive for Clinical and Experimental Ophthalmology",

issn = "0721-832X",

publisher = "Springer Science and Business Media Deutschland GmbH",

number = "7",

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Wespiser, S, Koestel, E, Fabacher, T, Sauer, A, Aptel, F, Arnould, L, Asoklis, R, Baillif, S, Baudouin, C, Becmeur, PH, Bernheim, D, Bocksei, Z, Borderie, V, Bouheraoua, N, Bourges, JL, Bron, A, Burillon, C, Carnt, N, Chiquet, C, Cochener, B, Cochereau, I, Creuzot-Garcher, C, David, T, Fogagnolo, P, Dormegny, L, Fournie, P, Gaucher, D, Gohier, P, Gomart, G, Grupcheva, C, Gueudry, J, Ho Wang Yin, G, Hoffart, L, Imhof, S, Ivekovic, R, Knoeri, J, Kodjikian, L, Kosacki, J, Labetoulle, M, Legeais, JM, Martinez-Costa, R, Megevand-Sunaric, G, Messerlin, A, Meyer, L, Meyer, N, Merle, H, Mouriaux, F, Muraine, M, Porro, G, Wisse, R 2023, 'Practice patterns in the management of bacterial keratitis: a five-continent survey', Graefe's Archive for Clinical and Experimental Ophthalmology, vol. 261, no. 7, pp. 1961-1969. https://doi.org/10.1007/s00417-023-06003-6

TY - JOUR

T1 - Practice patterns in the management of bacterial keratitis

T2 - a five-continent survey

AU - Wespiser, Simon

AU - Koestel, Emilia

AU - Fabacher, Thibaut

AU - Sauer, Arnaud

AU - Aptel, Florent

AU - Arnould, Louis

AU - Asoklis, Rimvydas

AU - Baillif, Stephanie

AU - Baudouin, Christophe

AU - Becmeur, Pierre Henri

AU - Bernheim, Diane

AU - Bocksei, Zsolt

AU - Borderie, Vincent

AU - Bouheraoua, Nacim

AU - Bourges, Jean Louis

AU - Bron, Alain

AU - Burillon, Carole

AU - Carnt, Nicole

AU - Chiquet, Christophe

AU - Cochener, Beatrice

AU - Cochereau, Isabelle

AU - Creuzot-Garcher, Catherine

AU - David, Thierry

AU - Fogagnolo, Paolo

AU - Dormegny, Lea

AU - Fournie, Pierre

AU - Gaucher, David

AU - Gohier, Philippe

AU - Gomart, Gabrielle

AU - Grupcheva, Christina

AU - Gueudry, Julie

AU - Ho Wang Yin, Gaëlle

AU - Hoffart, Louis

AU - Imhof, Saskia

AU - Ivekovic, Renata

AU - Knoeri, Juliette

AU - Kodjikian, Laurent

AU - Kosacki, Julie

AU - Labetoulle, Marc

AU - Legeais, Jean Marc

AU - Martinez-Costa, Rafael

AU - Megevand-Sunaric, Gordana

AU - Messerlin, Arnaud

AU - Meyer, Laurent

AU - Meyer, Nicolas

AU - Merle, Harold

AU - Mouriaux, Frédéric

AU - Muraine, Marc

AU - Porro, Giorgio

AU - Wisse, Robert

PY - 2023/7

Y1 - 2023/7

N2 - PURPOSE: To assess the current diagnostic and therapeutic practice patterns in early management of bacterial keratitis over five continents.METHODS: Between March and August 2019, we distributed an online survey including two clinical scenarios of bacterial keratitis, namely, a mild case and severe case, to 2936 ophthalmologists from 144 countries around the world. The survey consisted of 29 questions. We performed descriptive statistics and a comparative analysis of the answers according to the participants' continent of practice, practice setting, seniority, and subspecialty.RESULTS: We received 237 surveys from 54 countries (8% response rate). The proportion of respondents performing microbiological investigations was higher in North America, Asia, Europe, and Oceania than Africa and South America (p < 0.05). This ratio was also higher among ocular surface specialists than for other ophthalmologists (p < 0.001). For mild cases, fluoroquinolone monotherapy and a combination of two or more antibiotics were prescribed by 46% and 41% respondents, respectively. For severe cases, fluoroquinolone monotherapy and a combination of antibiotics were prescribed by 20% and 78% respondents, respectively. Fluoroquinolone monotherapy was the most commonly prescribed treatment in South America, Africa, and Oceania. A combination of two antibiotics was preferentially prescribed in the rest of the world. Topical steroids were prescribed in both circumstances, respectively, in 72% and 75% of cases.CONCLUSION: Our results highlight essential geographical disparities in the current management of bacterial keratitis over five continents.

AB - PURPOSE: To assess the current diagnostic and therapeutic practice patterns in early management of bacterial keratitis over five continents.METHODS: Between March and August 2019, we distributed an online survey including two clinical scenarios of bacterial keratitis, namely, a mild case and severe case, to 2936 ophthalmologists from 144 countries around the world. The survey consisted of 29 questions. We performed descriptive statistics and a comparative analysis of the answers according to the participants' continent of practice, practice setting, seniority, and subspecialty.RESULTS: We received 237 surveys from 54 countries (8% response rate). The proportion of respondents performing microbiological investigations was higher in North America, Asia, Europe, and Oceania than Africa and South America (p < 0.05). This ratio was also higher among ocular surface specialists than for other ophthalmologists (p < 0.001). For mild cases, fluoroquinolone monotherapy and a combination of two or more antibiotics were prescribed by 46% and 41% respondents, respectively. For severe cases, fluoroquinolone monotherapy and a combination of antibiotics were prescribed by 20% and 78% respondents, respectively. Fluoroquinolone monotherapy was the most commonly prescribed treatment in South America, Africa, and Oceania. A combination of two antibiotics was preferentially prescribed in the rest of the world. Topical steroids were prescribed in both circumstances, respectively, in 72% and 75% of cases.CONCLUSION: Our results highlight essential geographical disparities in the current management of bacterial keratitis over five continents.

KW - Antibiotics

KW - Bacterial keratitis

KW - Diagnosis

KW - Survey

KW - Treatment

UR - https://www.scopus.com/pages/publications/85148656453

U2 - 10.1007/s00417-023-06003-6

DO - 10.1007/s00417-023-06003-6

M3 - Article

C2 - 36820985

AN - SCOPUS:85148656453

SN - 0721-832X

VL - 261

SP - 1961

EP - 1969

JO - Graefe's Archive for Clinical and Experimental Ophthalmology

JF - Graefe's Archive for Clinical and Experimental Ophthalmology

IS - 7

ER -

Practice patterns in the management of bacterial keratitis: a five-continent survey

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