Practical Approach for Angina and Non-Obstructive Coronary Arteries: A State-of-the-Art Review

Coen K M Boerhout; Marcel A M Beijk; Peter Damman; Jan J Piek; Tim P van de Hoef

doi:10.4070/kcj.2023.0109

Practical Approach for Angina and Non-Obstructive Coronary Arteries: A State-of-the-Art Review

Coen K M Boerhout
, Marcel A M Beijk
, Peter Damman
, Jan J Piek
, Tim P van de Hoef^*

^*Corresponding author for this work

Division of Heart & Lungs

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Anginal symptoms are frequently encountered in patients without the presence of significant obstructive coronary artery disease (CAD). It is increasingly recognized that vasomotor disorders, such as an abnormal vasodilatory capacity of the coronary microcirculation or coronary vasospasm, are the dominant pathophysiological substrate in these patients. Although the evidence with respect to angina in patients with non-obstructive coronary arteries is accumulating, the diagnosis and treatment of these patients remains challenging. In this review, we aimed to provide a comprehensive overview regarding the pathophysiological origins of angina with non-obstructive coronary arteries disorders and its diagnostic and therapeutic considerations. Hereby, we provide a practical approach for the management of patents with angina and non-obstructive CAD.

Original language	English
Article number	e52
Pages (from-to)	519-534
Number of pages	16
Journal	Korean circulation journal
Volume	53
Issue number	8
DOIs	https://doi.org/10.4070/kcj.2023.0109
Publication status	Published - Aug 2023

Keywords

ANOCA
Abnormal vasodilatory capacity
Coronary microvascular disease
Vasospasm

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10.4070/kcj.2023.0109Licence: CC BY-NC

0054KCJ_kcj-53-519Final published version, 2.01 MBLicence: CC BY-NC

Cite this

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title = "Practical Approach for Angina and Non-Obstructive Coronary Arteries: A State-of-the-Art Review",

abstract = "Anginal symptoms are frequently encountered in patients without the presence of significant obstructive coronary artery disease (CAD). It is increasingly recognized that vasomotor disorders, such as an abnormal vasodilatory capacity of the coronary microcirculation or coronary vasospasm, are the dominant pathophysiological substrate in these patients. Although the evidence with respect to angina in patients with non-obstructive coronary arteries is accumulating, the diagnosis and treatment of these patients remains challenging. In this review, we aimed to provide a comprehensive overview regarding the pathophysiological origins of angina with non-obstructive coronary arteries disorders and its diagnostic and therapeutic considerations. Hereby, we provide a practical approach for the management of patents with angina and non-obstructive CAD.",

keywords = "ANOCA, Abnormal vasodilatory capacity, Coronary microvascular disease, Vasospasm",

author = "Boerhout, \{Coen K M\} and Beijk, \{Marcel A M\} and Peter Damman and Piek, \{Jan J\} and \{van de Hoef\}, \{Tim P\}",

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year = "2023",

month = aug,

doi = "10.4070/kcj.2023.0109",

language = "English",

volume = "53",

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journal = "Korean circulation journal",

issn = "1738-5520",

publisher = "Korean Society of Cardiology",

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TY - JOUR

T1 - Practical Approach for Angina and Non-Obstructive Coronary Arteries

T2 - A State-of-the-Art Review

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AU - Beijk, Marcel A M

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AU - Piek, Jan J

AU - van de Hoef, Tim P

PY - 2023/8

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N2 - Anginal symptoms are frequently encountered in patients without the presence of significant obstructive coronary artery disease (CAD). It is increasingly recognized that vasomotor disorders, such as an abnormal vasodilatory capacity of the coronary microcirculation or coronary vasospasm, are the dominant pathophysiological substrate in these patients. Although the evidence with respect to angina in patients with non-obstructive coronary arteries is accumulating, the diagnosis and treatment of these patients remains challenging. In this review, we aimed to provide a comprehensive overview regarding the pathophysiological origins of angina with non-obstructive coronary arteries disorders and its diagnostic and therapeutic considerations. Hereby, we provide a practical approach for the management of patents with angina and non-obstructive CAD.

AB - Anginal symptoms are frequently encountered in patients without the presence of significant obstructive coronary artery disease (CAD). It is increasingly recognized that vasomotor disorders, such as an abnormal vasodilatory capacity of the coronary microcirculation or coronary vasospasm, are the dominant pathophysiological substrate in these patients. Although the evidence with respect to angina in patients with non-obstructive coronary arteries is accumulating, the diagnosis and treatment of these patients remains challenging. In this review, we aimed to provide a comprehensive overview regarding the pathophysiological origins of angina with non-obstructive coronary arteries disorders and its diagnostic and therapeutic considerations. Hereby, we provide a practical approach for the management of patents with angina and non-obstructive CAD.

KW - ANOCA

KW - Abnormal vasodilatory capacity

KW - Coronary microvascular disease

KW - Vasospasm

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DO - 10.4070/kcj.2023.0109

M3 - Article

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SP - 519

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JF - Korean circulation journal

IS - 8

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ER -

Practical Approach for Angina and Non-Obstructive Coronary Arteries: A State-of-the-Art Review

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