TY - JOUR
T1 - Postoperative Radiotherapy for pT1- and pT2-Classified Squamous Cell Carcinoma of the External Auditory Canal †
AU - Nabuurs, Cindy H.
AU - Kievit, Wietske
AU - Leemans, Charles (René) Reinier
AU - Smit, Conrad F.G.M.
AU - van den Brekel, Michiel W.M.
AU - Pauw, Robert J.
AU - van der Laan, Bernard F.A.M.
AU - Jansen, Jeroen C.
AU - Lacko, Martin
AU - Braunius, Weibel W.
AU - Dai, Chunfu
AU - Shi, Xunbei
AU - Danesi, Giovanni
AU - Bouček, Jan
AU - Borsetto, Daniele
AU - Gowrishankar, Shavran
AU - Kania, Romain
AU - Jourdaine, Clément
AU - Jansen, Thijs T.G.
AU - Derks, Jolanda
AU - Dijkema, Tim
AU - Takes, Robert P.
AU - Kunst, Henricus (Dirk) P.M.
N1 - Publisher Copyright:
© 2024 by the authors.
PY - 2024/12
Y1 - 2024/12
N2 - Background: There is no consensus regarding the indication for postoperative radiotherapy (PORT) for T1- and T2-classified squamous cell carcinoma (SCC) of the external auditory canal (EAC) even with negative surgical margins. This study aimed to evaluate whether PORT provides additional benefits for these cases. Methods: We collected retrospective data from fourteen international hospitals, including resected pT1- and pT2-classified EAC SCC with negative surgical margins. Results: A total of 112 early-stage radically resected EAC SCC were included, with 48 patients receiving PORT. The 5-year DFS of T1- and T2-classified EAC SCC treated with PORT was not statistically significantly different (92.9% and 76.9%, respectively) compared to the group treated without PORT (100% and 90.9%, respectively; p-values of 0.999 and 0.526, respectively). EAC SCC treated with PORT more frequently exhibited perineural and angioinvasive growth. Eighteen patients experienced side effects related to radiotherapy, of which one patient developed osteoradionecrosis. Conclusions: Our study suggests that PORT for early-stage radically resected EAC SCC should only be considered in selected cases with perineural, infiltrative growth or angioinvasive growth, and with a close margin. This approach helps mitigate the negative impact on quality of life and the risk of side effects associated with radiotherapy.
AB - Background: There is no consensus regarding the indication for postoperative radiotherapy (PORT) for T1- and T2-classified squamous cell carcinoma (SCC) of the external auditory canal (EAC) even with negative surgical margins. This study aimed to evaluate whether PORT provides additional benefits for these cases. Methods: We collected retrospective data from fourteen international hospitals, including resected pT1- and pT2-classified EAC SCC with negative surgical margins. Results: A total of 112 early-stage radically resected EAC SCC were included, with 48 patients receiving PORT. The 5-year DFS of T1- and T2-classified EAC SCC treated with PORT was not statistically significantly different (92.9% and 76.9%, respectively) compared to the group treated without PORT (100% and 90.9%, respectively; p-values of 0.999 and 0.526, respectively). EAC SCC treated with PORT more frequently exhibited perineural and angioinvasive growth. Eighteen patients experienced side effects related to radiotherapy, of which one patient developed osteoradionecrosis. Conclusions: Our study suggests that PORT for early-stage radically resected EAC SCC should only be considered in selected cases with perineural, infiltrative growth or angioinvasive growth, and with a close margin. This approach helps mitigate the negative impact on quality of life and the risk of side effects associated with radiotherapy.
KW - disease-free survival
KW - radiotherapy
KW - squamous cell carcinoma
KW - temporal bone
KW - treatment
UR - http://www.scopus.com/inward/record.url?scp=85212220578&partnerID=8YFLogxK
U2 - 10.3390/cancers16234026
DO - 10.3390/cancers16234026
M3 - Article
AN - SCOPUS:85212220578
SN - 2072-6694
VL - 16
JO - Cancers
JF - Cancers
IS - 23
M1 - 4026
ER -